Age-related trends in aperiodic EEG activity and alpha oscillations during early- to middle-childhood

McSweeney, Marco; Morales, Santiago; Valadez, Emilio A.; Buzzell, George A.; Yoder, Lydia; Fifer, William P.; Pini, Nicolò; Shuffrey, Lauren C.; Elliott, Amy J.; Isler, Joseph R.

doi:10.1016/j.neuroimage.2023.119925

Cited by 16 publications

(48 citation statements)

References 57 publications

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“…Modeled developmental trajectories of the aperiodic slope showed a qualitatively gradual increase over the first year. These findings contrast with consistent reports of decreasing offset and slope across child and adulthood [13][14][15][16] , and likely reflect the known increases in brain volume and synaptogenesis occurring across the first year of life.…”

Section: Aperiodic Activity Increases Most During First Year Of Lifecontrasting

confidence: 99%

“…Several age-dependent findings in our study contrast with previous longitudinal studies of child and adulthood. First, we observe increases in both aperiodic offset and slope, especially during the first year, whereas decreases in both measures are observed starting as early as 4 years of age and continue to decrease with adulthood [13][14][15][16] . Second, while expected shifts in the dominant peak from the theta to alpha range were observed between 5 to 44 months, in the 2-4 months age bin, a 9.5Hz peak was also transiently observed.…”

Section: Discussionmentioning

confidence: 78%

“…In addition, recent evidence suggests that the aperiodic slope reflects the excitatoryinhibitory (E/I) balance of the underlying neuronal network, where a flattened, reduced slope is associated with increased excitation over inhibition, and a steeply more accelerated slope with increased inhibition over excitation 11 . Longitudinal studies extending from childhood to adulthood have observed decreases in aperiodic slope with age, suggestive of increases in E/I balance with age [13][14][15][16] . Changes in the aperiodic component in early infancy are less well described, and we hypothesize they may be substantially different from those in childhood, as the first year after birth includes rapid increases in neuronal activity, synaptogenesis, and inhibitory neuron integration.…”

Section: Introductionmentioning

confidence: 99%

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Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy

Wilkinson¹,

Yankowitz²,

Chao³

et al. 2023

Preprint

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The time-course of developing brain circuits plays a fundamental role in brain maturation and later cognitive functioning, but thus far has been poorly characterized in humans. Here, aperiodic and periodic EEG power features were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Consistent with the transient developmental progression of thalamocortical circuitry, we observe the presence and then absence of periodic alpha and high beta peaks across the three-year period, as well as the emergence of a low beta peak (12-20Hz) after six months of age. We present preliminary evidence that the emergence of the low beta peak is associated with thalamocortical connectivity sufficient for anesthesia-induced alpha coherence. Together, these findings suggest that early age-dependent changes in alpha and beta periodic peaks may reflect the state of thalamocortical network development.

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Section: Aperiodic Activity Increases Most During First Year Of Lifecontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy

Wilkinson¹,

Yankowitz²,

Chao³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Because the peak and range of alpha oscillations may vary across age and individuals (Bazanova & Vernon, 2014; Sander et al., 2012), in an exploratory analysis, we employed novel ways of characterizing the power spectrum by using specparam (Donoghue et al., 2022). The specparam algorithm removes the 1/f component of the spectrum and uses an iterative procedure to identify peaks (e.g., alpha peaks; see McSweeney et al., 2023). Path analyses were conducted as with the traditionally computed alpha.…”

Section: Resultsmentioning

confidence: 99%

“…The specparam algorithm removes the 1/f component of the spectrum and TA B L E 3 Maternal internalizing symptoms at the prenatal period predicting children's frontal alpha asymmetry and internalizing/externalizing problems at 5, 7, 9, or 11 years of age (n = 415). uses an iterative procedure to identify peaks (e.g., alpha peaks; see McSweeney et al, 2023). Path analyses were conducted as with the traditionally computed alpha.…”

Section: Exploratory Analysesmentioning

confidence: 99%

Examining the impact of prenatal maternal internalizing symptoms and socioeconomic status on children's frontal alpha asymmetry and psychopathology

Hernandez,

Sania,

Bowers

et al. 2024

Developmental Psychobiology

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Prenatal maternal internalizing psychopathology (depression and anxiety) and socioeconomic status (SES) have been independently associated with higher risk for internalizing and externalizing problems in children. However, the pathways behind these associations are not well understood. Numerous studies have linked greater right frontal alpha asymmetry to internalizing problems; however, findings have been mixed. Several studies have also linked maternal internalizing psychopathology to children's frontal alpha asymmetry. Additionally, emerging studies have linked SES to children's frontal alpha asymmetry. To date, only a limited number of studies have examined these associations within a longitudinal design, and the majority have utilized relatively small samples. The current preregistered study utilizes data from a large prospective study of young children (N = 415; Meanage = 7.27 years; Rangeage = 5–11 years) to examine the association between prenatal maternal internalizing symptoms, children's frontal alpha asymmetry, and behavior problems. Prenatal maternal internalizing symptoms did not predict children's frontal alpha asymmetry, and there was no association between frontal alpha asymmetry and behavior problems. However, mothers’ internalizing symptoms during pregnancy predicted children's internalizing and externalizing outcomes. Non‐preregistered analyses showed that lower prenatal maternal SES predicted greater child right frontal alpha asymmetry and internalizing problems. Additional non‐preregistered analyses did not find evidence for frontal alpha asymmetry as a moderator of the relation between prenatal maternal internalizing psychopathology and SES to children's behavior problems. Future research should examine the impact of SES on children's frontal alpha asymmetry in high‐risk samples.

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Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics

Picci,

Ott,

Penhale

et al. 2023

Human Brain Mapping

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The transition from childhood to adolescence is associated with an influx of sex hormones, which not only facilitates physical and behavioral changes, but also dramatic changes in neural circuitry. While previous work has shown that pubertal hormones modulate structural and functional brain development, few of these studies have focused on the impact that such hormones have on spontaneous cortical activity, and whether these effects are modulated by sex during this critical developmental window. Herein, we examined the effect of endogenous testosterone on spontaneous cortical activity in 71 typically‐developing youth (ages 10–17 years; 32 male). Participants completed a resting‐state magnetoencephalographic (MEG) recording, structural MRI, and provided a saliva sample for hormone analysis. MEG data were source‐reconstructed and the power within five canonical frequency bands (delta, theta, alpha, beta, and gamma) was computed. The resulting power spectral density maps were analyzed via vertex‐wise ANCOVAs to identify spatially specific effects of testosterone and sex by testosterone interactions, while covarying out age. We found robust sex differences in the modulatory effects of testosterone on spontaneous delta, beta, and gamma activity. These interactions were largely confined to frontal cortices and exhibited a stark switch in the directionality of the correlation from the low (delta) to high frequencies (beta/gamma). For example, in the delta band, greater testosterone related to lower relative power in prefrontal cortices in boys, while the reverse pattern was found for girls. These data suggest testosterone levels are uniquely related to the development of spontaneous cortical dynamics during adolescence, and such levels are associated with different developmental patterns in males and females within regions implicated in executive functioning.

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Age-related trends in aperiodic EEG activity and alpha oscillations during early- to middle-childhood

Cited by 16 publications

References 57 publications

Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy

Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy

Examining the impact of prenatal maternal internalizing symptoms and socioeconomic status on children's frontal alpha asymmetry and psychopathology

Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics

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