Age-related transmural peak mean velocities and peak velocity gradients by Doppler myocardial imaging in normal subjects

Palka, Przemysław; Lange, Aleksandra; Fleming, Alan; Fenn, Lynn N.; Bouki, Konstantina P.; Shaw, Thomas R.; Fox, Keith A.A.; McDicken, W.N.; Sutherland, George R.

doi:10.1093/oxfordjournals.eurheartj.a014977

Cited by 107 publications

(63 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, isovolumic relaxation time had a variable duration, although it was not significantly shorter in the basal segments. The fact that most systolic parameters did not change with age is in accordance with the little deterioration in systolic function with aging [28][29][30] . In regard to diastole, a reduction in e, an increase in a, and an inversion in e/a have been observed with age, coinciding with those reported.…”

Section: Discussionsupporting

confidence: 68%

“…The regional isovolumic relaxation time is shorter in the basal segments on apical view (reflecting myocardial electric activation) and longer in the anterior septum on the parasternal view 18 . With aging [28][29][30] , a slight reduction in the velocities of s is observed, as are a significant reduction in the velocity of e, an increase in a, and an inversion in e/a. According to a recent study 30 with healthy volunteers under the age of 40 years, regional e/a was always > 1, and the number of segments with e/a <1 increased with age initially in the basal segments and in the longitudinal axis.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Regional myocardial function in healthy adults: assessment through tissue Doppler echocardiography

Cardim¹,

Oliveira²,

Longo³

et al. 2003

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

OBJECTIVE: To characterize left ventricular regional myocardial function through tissue Doppler echocardiography in healthy adults and to assess the influence of aging in this function. METHODS: In 45 healthy volunteers divided in two groups (< 45 and > 45 years old) we assessed longitudinal and radial regional function (velocities, times intervals and velocity-time integrals). Data were compared in each group and between groups. RESULTS: Systolic function: a) longitudinal: higher velocities and integrals in lateral and inferior walls and in basal segments, with a trend to reduction of these parameters with aging; b) radial: higher basal velocities, no significant change with aging. Diastolic function: a) longitudinal: higher velocities in lateral and inferior walls and in basal segments. With aging e and e/a velocities and integrals decreased, a increased and older individuals showed lower percentage of segments with e/a >1; b) radial: aging was associated with lower e and higher a velocities. CONCLUSION: 1) Tissue Doppler echocardiography detects physiological differences between regional myocardial function of different ventricular segments, in velocities, times intervals and integrals, with physiological heterogeneity and asynchrony; 2) Many of these data are age dependent; 3) Our data contribute to define normal values, and may become useful when compared with data from populations with heart diseases

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 98%

Regional myocardial function in healthy adults: assessment through tissue Doppler echocardiography

Cardim¹,

Oliveira²,

Longo³

et al. 2003

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…On the other hand, the observed tendencies can be regarded consistently with previous findings: according to data in the literature, older patients in our study had both reduced CCA volume flow 15,16 and reduced cardiac function. 18,19 An independent effect of the cardiac output on carotid volume flow was not observed.…”

Section: Discussionmentioning

confidence: 89%

Lack of association between carotid artery volume blood flow and cardiac output.

Eicke

Schlichting²,

Mohr-Ahaly³

et al. 2001

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objective. The correlation of cardiac output and cerebral perfusion is unclear. We tested this potential association by correlating cardiac output data obtained by echocardiography and cerebral blood flow data as determined by color M-mode measurements of carotid artery blood flow. Methods. We studied 43 patients with a broad spectrum of cardiac performance by means of transthoracic echocardiography. In these patients, different cardiac indices such as stroke volume, ejection fraction, and heart minute volume were determined. The data were correlated with volumetric flow measurements (color M-mode duplex system) of the common carotid arteries bilaterally. Results. Heart minute volume ranged from 1.632 to 9.836 mL/min (mean ± SD, 4.652 ± 1.621 mL/min); ejection fraction ranged from 18% to 76% (mean, 48% ± 16%). The relative fraction of carotid volume flow compared with heart minute volume was 15% ± 6%. There was no correlation between ejection fraction, stroke volume, or heart minute volume and absolute volume flow in the carotid arteries when being adjusted for age. There was a highly significant inverse correlation (r = -0.8; P < .0001) of the relative fraction of the carotid volume flow (carotid volume flow/heart minute volume [percent]) and the heart minute volume. Conclusion. Our data support the concept that cerebral blood flow is independent of cardiac output. Key words: cardiac output; cerebrovascular circulation; ultrasonography.Received January 18, 2001, from the Departments of Neurology (B.M.E., J.v.S., H.C.H.) and Cardiology (S.M.-K., A.S., R.S.v.B.) Abbreviations ASV, absolute stroke volume; BS, body surface; CBF, cerebral blood flow; CCA, common carotid artery; CI, cardiac index; EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; HMV, heart minute volume; HR, heart rate; LV, left ventricular; RSV, relative stroke volume; SPECT, single-photon emission computed tomography; Vol, volume erebral autoregulation maintains constant brain perfusion over a wide blood pressure range between 60 and 150 mm Hg. 1 Within these limits, cerebral blood flow (CBF) is not directly correlated with cerebral perfusion pressure. 2 A review of the literature suggests that the impact of cardiac output on CBF is uncertain, with conflicting data in animals, healthy volunteers, and neurosurgical or cardiologic patients. [3][4][5][6][7][8] In addition, methodological differences to define CBF enhance difficulties with interpreting these studies. Cerebral blood flow was assessed by means of singlephoton emission computed tomography (SPECT) 3,6,7 or blood flow velocity of the middle cerebral artery. 9 These methods are difficult, because they either require radioactive tracers (SPECT) or reflect only flow velocity (transcranial Doppler ultrasonography) rather than flow volume data. Clinical trials comparing xenon Xe 133 SPECT and transcranial Doppler data revealed conflict-

show abstract

“…The ratio of the two wall motion velocities during diastole (Ew/Aw) in young normal individuals is >1. This ratio decreases with age [52,55,56], and along both the long and short axes [57].…”

Section: Diastolic Functionmentioning

confidence: 95%

The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left Ventricular Function

Oki

2003

J Echocardiogr

View full text Add to dashboard Cite

In general, pump function and myocardial contractility should be assessed when evaluating left ventricular (LV) systolic function. Ejection fraction obtained from left ventriculography is routinely used as an index of pump function, and the maximum value of the first derivative of LV pressure curve (peak dP/dt) has been used as an index of myocardial contractility. On the other hand, active relaxation of the LV myocardium during early diastole and LV passive filling or compliance during mid-to late diastole are important factors in evaluating LV diastolic function. To obtain this information, the time constant of the LV pressure decay during isovolumic diastole (tau) and LV end-diastolic pressure, which are calculated from the LV pressure curve recorded during cardiac catheterization, is used. However, invasive hemodynamic measurements cannot be performed in all patients, nor are they appropriate for follow-up evaluation involving repeated examinations.Recently, routine echocardiography has facilitated the noninvasive evaluation of LV systolic and diastolic function. The percent fractional shortening of the LV based on M-mode echocardiography and the LV ejection fraction determined by two-dimensional echocardiography are indices of LV pump function, and therefore cannot accurately evaluate LV myocardial contractility. On the other hand, "diastology" has become an important clinical topic [1]. There are several reasons why assessment of diastolic function is important: 1) 30 to 40% of patients evaluated for congestive heart failure have normal LV pump function [2,3]; 2) the transmitral flow velocity pattern, which is recorded using the pulsed Doppler method, may be an index for noninvasive evaluation of LV diastolic function [4]; and 3) the prognosis is poor in patients with LV systolic dysfunction and pseudonormalization or restrictive pattern of the transmitral flow velocity [5,6]. However, it has been shown that the diastolic indices obtained from transmitral and pulmonary venous flow velocities are influenced by loading conditions, especially by the pre- The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left AbstractThe widespread use of the pulsed Doppler echocardiography has facilitated the noninvasive evaluation of hemodynamic abnormalities of the left atrium and left ventricle (LV) based on transmitral and pulmonary venous flow velocity patterns. However, it has been shown that loading conditions, especially preload, influence the indices obtained from these velocity patterns. Recently, tissue Doppler imaging (TDI) has been applied to the clinical setting to assess LV myocardial function. In particular, this procedure has the following characteristics: 1) it can provide circumferential and longitudinal information for the LV myocardium; 2) the early diastolic LV myocardial parameters determined by TDI are not influenced by preload; 3) LV myocardial contractility can be evaluated from the early systolic parameters; 4) LV systolic and diastolic asynchrony can be detected; 5) myoca...

show abstract

Age-related transmural peak mean velocities and peak velocity gradients by Doppler myocardial imaging in normal subjects

Cited by 107 publications

References 11 publications

Regional myocardial function in healthy adults: assessment through tissue Doppler echocardiography

Regional myocardial function in healthy adults: assessment through tissue Doppler echocardiography

Lack of association between carotid artery volume blood flow and cardiac output.

The Role of Tissue Doppler Imaging as a New Diagnostic Option in Evaluating Left Ventricular Function

Contact Info

Product

Resources

About