2011
DOI: 10.1590/s1677-55382011000500004
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Age-related testosterone decline in a Brazilian cohort of healthy military men

Abstract: Introduction: Androgen decline in the aging man has become a topic of increasing clinical relevance worldwide, as the reduction in testosterone levels has been reported to be accompanied by loss of muscle mass, accumulation of central adiposity, impaired mobility and increase risk of bone fractures. Although well-established in studies conducted in developed countries, progressive decline in serum testosterone levels with age has been poorly investigated in Brazil. Aim: To determine the pattern of blood testos… Show more

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Cited by 17 publications
(10 citation statements)
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(31 reference statements)
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“…A sex-specific predisposition for abdominal, or visceral, adiposity in men may be due to adipose-regulating effects of testosterone. Although aging men do not experience a menopause-like dramatic decrease in sex hormone levels as experienced by women, testosterone levels decline steadily with age in men [34]. These declining testosterone levels are associated with elevated visceral adiposity observed in aging men [35], which may play a role in increased cardiovascular risk in aging men.…”
Section: Main Textmentioning
confidence: 99%
“…A sex-specific predisposition for abdominal, or visceral, adiposity in men may be due to adipose-regulating effects of testosterone. Although aging men do not experience a menopause-like dramatic decrease in sex hormone levels as experienced by women, testosterone levels decline steadily with age in men [34]. These declining testosterone levels are associated with elevated visceral adiposity observed in aging men [35], which may play a role in increased cardiovascular risk in aging men.…”
Section: Main Textmentioning
confidence: 99%
“…High serum testosterone is associated with reduced subcutaneous and increased abdominal adiposity in women, while low testosterone is associated with the same effect in men [25][26][27]. In older men, sex hormone levels do not decrease as rapidly as in menopausal women however, testosterone levels decline steadily with age [28].These declining testosterone levels have been reported to be associated with elevated visceral adiposity in older men [29]. This may play a role in increased risk of cardiovascular diseases in aging men.…”
Section: Discussionmentioning
confidence: 99%
“…The age-associated decrease in T levels varies highly across individuals, and enormous variations in T values are observed in men of all ages. Additionally, the average level of total serum T in 75-year-olds is approximately 66% of the level in 25-year-olds, but the average values of free and bioavailable serum T in older men are approximately half of those of healthy young men (Feldman et al, 2002; Harman et al, 2001; Nardozza Junior, Szelbracikowski Sdos, Nardi, & Almeida, 2011; Vermeulen, Kaufman, & Giagulli, 1996; Zmuda et al, 1997). Further investigation is thus required to address the role of the free T fraction rather than of total serum T, which was considered in the present study.…”
Section: Discussionmentioning
confidence: 99%