Age-Related Structural and Metabolic Changes in the Pelvic Reproductive End Organs

Well, David; Yang, Hua; Houseni, Mohamed; Iruvuri, Sireesha; Alzeair, Saad; Sansovini, Maddalena; Wintering, Nancy; Alavi, Abass; Torigian, Drew A.

doi:10.1053/j.semnuclmed.2007.01.004

Cited by 61 publications

(54 citation statements)

References 126 publications

(163 reference statements)

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“…Age-related increase in gonadotropins is mainly due to primary testicular failure. Testicular metabolism increases between 11 and 40 years of age, and it gradually decreases between the ages of 40 and 90 [8,9].…”

Section: The Effect Of Aging On Sexual Organsmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

190

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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Section: The Effect Of Aging On Sexual Organsmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

190

118

View full text Add to dashboard Cite

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“…Imaging techniques have also shown promise for assessing the aging process in a variety of organs and systems [1][2][3][4][5]. Unlike serologic and histologic examinations, modern imaging methodologies enable both global and local quantitative analyses of structural and functional data within and among individual subjects.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Aging on Testicular Volume and Glucose Metabolism: an Investigation with Ultrasonography and FDG-PET

et al. 2010

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Testicular volume and metabolism appear to be significantly affected by advancing age at different rates during the different stages of lifespan. The rapid increase in testicular volume and metabolism parallel the onset and progression of puberty and positively correlate with increasing age up to ages 30-40 years. Between ages 40 and 60 years, testicular volume and metabolism remain relatively constant with only a minimal decline. After age of 60 years, the testicular volume significantly declines, while testicular metabolism progressively declines until age 90 years.

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“…Decrease in the volume of the uterine body and thickness of the endometrium have been reported in postmenopausal subjects and are explained by the decreased serum levels of estrogen and progesterone. 9,11,12 We suggest that the uterine changes observed in the premenopausal group might reflect morphological changes caused by the ovarian toxicity of chemotherapy and the following decreased levels of sex steroid. The combination of our MR imaging approach with comparison of surgical specimens after NACT with premenopausal organs of women of the same ages with the same conditions without NACT might provide valuable information about the practical management of chemotherapy-induced infertility.…”

Section: Discussionmentioning

confidence: 99%

“…1,[9][10][11][12][13][14][15] The changes observed in the MR appearance of ovaries in premenopausal patients, (i.e., decreased volume of the ovaries, intensity of ovarian tissues on T 2 -WI, and visualization of the follicles), could be explained by the ovarian toxicity induced by NACT. This toxicity might be primarily caused by the platinum-based compound.…”

Section: Discussionmentioning

confidence: 99%

MR Imaging-based Evaluation of Morphological Changes in the Uterus and Ovaries of Patients Following Neoadjuvant Chemotherapy for Cervical Cancer

et al. 2015

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Objective: We used magnetic resonance (MR) imaging and hormonal levels to evaluate the influence of chemotherapy for cervical cancer on female pelvic reproductive organs.Materials and Methods: We retrospectively evaluated 16 pre-and 11 postmenopausal patients with cervical cancer who underwent neoadjuvant chemotherapy (NACT) and radical surgery. We evaluated morphological changes in the uterus and ovaries by MR imaging both quantitatively and qualitatively, measuring the volume of the uterine body and bilateral ovaries, endometrial thickness, and signal intensity of the myometrium and bilateral ovaries and assessing visibility of the junctional zone and bilateral ovarian follicles. We compared both quantitative and qualitative factors between pre-and post-NACT. Pre-and post-NACT hormonal values of estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) of 8 patients in the premenopausal group were obtained and analyzed statistically.Results: In the premenopausal group, we observed a statistically significant decrease in all quantitative parameters as well as in the visibility of the left ovarian follicle. In the postmenopausal group, only endometrial thickness changed significantly. Premenopausal patients showed a statistically significant decrease in levels of progesterone, FSH, and LH after chemotherapy.Conclusions: MR demonstrated changes in the uterus and ovaries in premenopausal subjects who underwent chemotherapy that resembled those changes classically reported in physiological postmenopausal subjects. These changes are likely due to ovarian toxicity and secondary hormonal changes. MR imaging might be a valuable tool for obtaining information regarding chemotherapy-induced infertility.

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Age-Related Structural and Metabolic Changes in the Pelvic Reproductive End Organs

Cited by 61 publications

References 126 publications

Effects of aging on the male reproductive system

Effects of aging on the male reproductive system

The Effects of Aging on Testicular Volume and Glucose Metabolism: an Investigation with Ultrasonography and FDG-PET

MR Imaging-based Evaluation of Morphological Changes in the Uterus and Ovaries of Patients Following Neoadjuvant Chemotherapy for Cervical Cancer

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