Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 Months
Debresha A. Shelton,
Isabelle Gefke,
Vivian Summers
et al.
Abstract:Purpose: This study systematically evaluates age-related changes in RPE cell structure and function using a morphometric approach. We aim to better capture nuanced predictive changes in cell heterogeneity that reflect loss of RPE integrity during normal aging. Using C57BL6/J mice ranging from P60-P730, we sought to evaluate how regional changes in RPE shape reflect incremental losses in RPE cell function with advancing age. We hypothesize that tracking global morphological changes in RPE is predictive of funct… Show more
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