Age-related regional differences in cardiac nerve growth factor expression

Saygili, Erol; Kluttig, Rahel; Rana, Obaida R.; Saygılı, Esra; Gemein, Christopher; Zink, Matthias Daniel; Račkauskas, Gediminas; Weis, Joachim; Schwinger, Robert H. G.; Schauerte, Patrick

doi:10.1007/s11357-011-9262-0

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…A gradual increase in Ngf and TrkA expression also occurs with age. 29,30 These findings are consistent with a contribution of NGF to the change in autonomic tone observed in elderly patients. 30 At 60 days, NGF protein was significantly increased in the intact VP versus the sham despite the fact that Ngf RNA expression was highest in the denervated VP.…”

Section: Discussionsupporting

confidence: 74%

“…29,30 These findings are consistent with a contribution of NGF to the change in autonomic tone observed in elderly patients. 30 At 60 days, NGF protein was significantly increased in the intact VP versus the sham despite the fact that Ngf RNA expression was highest in the denervated VP. This increase in intact NGF protein suggests that with nerve perturbation, the adolescent, neurally intact prostate has both the appropriate neural signal and an undiminished capacity for epithelial response.…”

Section: Discussionsupporting

confidence: 74%

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Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

Podlasek

Ghosh²,

Çakır³

et al. 2013

Asian J Androl

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Benign prostatic hyperplasia (BPH) is a serious health concern and is an underlying cause of lower urinary tract symptoms (LUTS) in many men. In affected men, LUTS/BPH is believed to result from benign proliferation of the prostate resulting in bladder outlet obstruction. Postnatal growth of the prostate is controlled via growth factor and endocrine mechanisms. However, little attention had been given to the function of the autonomic nervous system in prostate growth and differentiation. Nerve growth factor (NGF) is a prostatic mitogen that has a trophic role in autonomic sensory end organ interaction. In this study, we examine how the autonomic nervous system influences prostate growth as a function of age by quantifying NGF in the rat ventral prostate (VP) after pelvic ganglionectomy. Unilateral pelvic ganglionectomy was performed on postnatal days 30 (P30), 60 and 120 Sprague-Dawley rats in comparison to sham controls (n539). Semiquantitative RT-PCR, Western blotting and immunohistochemical analysis for NGF were performed on denervated, intact (contralateral side) and sham control VP 7 days after surgery. Ngf RNA expression was significantly increased in the denervated and intact hyperplastic VP. Western blotting showed age-dependent increases in NGF protein at P60 in the contralateral intact VP. NGF was localized in the nerves, basal cells and columnar epithelium of the prostatic ducts. Denervation causes age-dependent increases in NGF in the VP, which is a potential mechanism by which the autonomic nervous system may regulate prostate growth and lead to BPH/LUTS. Asian Journal of Andrology (2013) Keywords: denervation; nerve growth factor; prostate growth; ventral prostate INTRODUCTION Benign prostatic hyperplasia (BPH) is a serious health concern worldwide and is an underlying cause of many lower urinary tract symptoms (LUTS). LUTS is common in aging men and a population based survey performed in five countries reports that ,64% of adults experience at least one LUTS symptom.1 LUTS has a profound impact on social functioning and quality of life in affected men 2,3 with similar effects reported as after a heart attack or stroke.4 BPH can induce acute urinary retention, incontinence, recurrent urinary tract infection or obstructive uropathy. LUTS secondary to BPH generally consists of three components: benign proliferation of the stroma and epithelium, bladder outlet obstruction and symptoms resulting from obstruction.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 74%

Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

Podlasek

Ghosh²,

Çakır³

et al. 2013

Asian J Androl

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“…121 Interestingly, another study demonstrated an age-dependent increase of ET-1/NGF protein expression in both atria, indicating the possibility that sympathetic hyperinnervation induced agerelated occurrence of AF. 166 However, because AF is a complex disease with multiple possible mechanisms, including inflammation, oxidative stress, and so on, further investigation is warranted to elucidate the precise mechanisms at play under specific conditions.…”

Section: Sympathetic Influence On Atrial Fibrillationmentioning

confidence: 99%

Development, Maturation, and Transdifferentiation of Cardiac Sympathetic Nerves

Kimura

Ieda

Fukuda

2012

Circulation Research

142

120

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Abstract:The heart is electrically and mechanically controlled as a syncytium by the autonomic nervous system. The cardiac nervous system comprises the sympathetic, parasympathetic, and sensory nervous systems that together regulate heart function on demand. Sympathetic electric activation was initially considered the main regulator of cardiac function; however, modern molecular biotechnological approaches have provided a new dimension to our understanding of the mechanisms controlling the cardiac nervous system. The heart is extensively innervated, although the innervation density is not uniform within the heart, being high in the subepicardium and the special conduction system. We and others showed previously that the balance between neural chemoattractants and chemorepellents determine cardiac nervous development, with both factors expressed in heart. Nerve growth factor is a potent chemoattractant synthesized by cardiomyocytes, whereas Sema3a is a neural chemorepellent expressed specifically in the subendocardium. Disruption of this wellorganized molecular balance and innervation density can induce sudden cardiac death due to lethal arrhythmias. In diseased hearts, various causes and mechanisms underlie cardiac sympathetic abnormalities, although their detailed pathology and significance remain contentious. We reported that cardiac sympathetic rejuvenation occurs in cardiac hypertrophy and, moreover, interleukin-6 cytokines secreted from the failing myocardium induce cholinergic transdifferentiation of the cardiac sympathetic system via a gp130 signaling pathway, affecting cardiac performance and prognosis. In this review, we summarize the molecular mechanisms involved in sympathetic development, maturation, and transdifferentiation, and propose their investigation as new therapeutic targets for heart disease. (Circ Res. 2012;110:325-336.) Key Words: cardiac sympathetic nervous system Ⅲ cardiac innervation patterning Ⅲ nerve growth factor Ⅲ cardiac rejuvenation Ⅲ cholinergic transdifferentiation Ⅲ IL-6 cytokines H eart tissue is extensively innervated via the autonomic nervous system, which comprises sympathetic and parasympathetic nerves. The cardiac sympathetic nervous system (SNS) uses norepinephrine (NE) as a neurotransmitter and increases the heart rate (chronotropic) and conduction velocity (dromotropic), as well as myocardial contraction (inotropic) and relaxation (lusitrophic). Sympathetic innervation density, which is highest in the subepicardium and central conduction system, is stringently regulated in the heart. 1 Regional differences in sympathetic innervation correspond to different areas of influence over cardiac function that cooperate to effectively control cardiac performance. Despite the clinical importance of cardiac innervation, little is known about the developmental and regulatory mechanisms underlying sympathetic innervation patterning.Cardiac innervation density is altered in pathological hearts, such as after myocardial infarction (MI), 2 in which the cardiac nerves undergo Walleria...

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“…Since the heart is comprehensively innervated by neural structures, including sympathetic and parasympathetic input, the influence of the local cardiac autonomic nervous system has to be considered in particular to draw a complete picture regarding cardiovascular events. The knowledge that heart muscle cells age dependently control the autonomic nervous system due to autocrine / paracrine mechanisms including the expression and secretion of acetylcholine and nerve growth factor, leading to a sympathetic hyperinnervation in the elderly, underlines this assumption [ 44 , 45 ]. In regard to this, further attention has to be given to the fact, that the occurrence of TCM is not only gender dependent in most cases, TCM occurs predominantly in the elderly.…”

Section: Autonomic Nervous System In the Elderlymentioning

confidence: 99%

Takotsubo Cardiomyopathy: What we have Learned in the Last 25 Years? (A Comparative Literature Review)

Said

Saygili²,

Rana³

et al. 2016

CCR

Self Cite

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We performed a comparative literature review, to elucidate the major features of the Takotsubo (stress) cardiomyopathy (TCM) collected in last 25 years.TCM is characterized by left- or biventricular apical ballooning with a clinical presentation, electrocardiographic abnormalities, and biomarker profils similar to those seen in acute myocardial infarction. Epidemiological studies have shown that TCM is more common in postmenopausal women; however exact figures are not available. The underlying aetiology is still largely undetermined. Elevated catecholamine levels, lack of estrogen, disturbed myocardial fatty acid metabolism and plaque rupture with spontaneous thrombolysis are potentially discussed mechanisms responsible for inducing a prolonged stunned myocardium. Strong emotional or physical stress is the most frequently described trigger in the literature. Therapy recommendations include appropriate antiplatelet treatment, β-blockers and ACE inhibitors. The abnormal kinetics usually resolve or improve within a month and carry a favorable prognosis in most cases. However, all the suspected complications of an acute myocardial infarction, including cardiogenic shock or lethal arrhythmias, may still occur.

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Age-related regional differences in cardiac nerve growth factor expression

Cited by 10 publications

References 26 publications

Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

Nerve growth factor signaling following unilateral pelvic ganglionectomy in the rat ventral prostate is age dependent

Development, Maturation, and Transdifferentiation of Cardiac Sympathetic Nerves

Takotsubo Cardiomyopathy: What we have Learned in the Last 25 Years? (A Comparative Literature Review)

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