Age-Related Progressive Brachial Artery Endothelial Dysfunction Precedes the Changed Carotid and Left Ventricular Geometry in Healthy Humans

Djurić, Dragan; Popovic, Zoran; Petrovic, J.; Bojić, Milovan

doi:10.1177/000331979905000705

Cited by 13 publications

(4 citation statements)

References 15 publications

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“…Unlike previous studies, the two groups examined in the present investigation were not precisely matched for age. An age-related decline in brachial artery FMD, including women with PCOS has been reported, 26,38,39 which was confirmed by our data, i.e. the higher the age, the more impaired was FMD.…”

Section: Discussionsupporting

confidence: 90%

Flow‐mediated dilatation in overweight and obese women with polycystic ovary syndrome

Brinkworth

Noakes

Moran

et al. 2006

BJOG

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Objective There remains a large degree of disagreement about the association of polycystic ovary syndrome (PCOS) with impaired endothelial dysfunction and cardiovascular disease (CVD) risk. The purpose of this study was to determine whether overweight and obese women with PCOS have impaired endothelial function compared with weight-matched controls without PCOS and whether endothelial function is associated with cardiovascular risk markers and hormonal parameters.Design Cross-sectional analysis. Setting An outpatient trial at the Commonwealth Scientific Industrial Research Organisation Clinical Research Unit.Population Overweight and obese women with PCOS (n = 12) and weight-matched controls without PCOS (n = 10).Methods Endothelial function, cardiovascular risk markers and hormonal parameters were assessed in the patients.Main outcome measures Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery using highresolution ultrasound. Lipid profile, fasting insulin level, glucose level, insulin resistance, C-reactive protein level, folate level, Vitamin B 12 level and hormonal parameters.Results Women with PCOS had significantly higher testosterone levels (P < 0.001) and free androgen index (P = 0.006) compared with the controls without PCOS. Both groups were normoinsulinaemic, and there were no significant differences in any of the markers of CVD between women with and without PCOS. Furthermore, FMD was similar in both groups (PCOS 6.1 ± 1.2% versus control 5.6 ± 1.0%, P = 0.77).Conclusions Compared with a group of weight-matched women with similar metabolic profiles, normoinsulinemic, overweight and obese women with PCOS did not show any greater impairment in endothelial function assessed by FMD. A normoinsulinemic phenotype of PCOS with low metabolic risk factors may reduce the risk of endothelial dysfunction in overweight and obese women with this syndrome. Further studies are required that directly compare FMD in normoinsulinemic and hyperinsulinaemic women with PCOS.

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Section: Discussionsupporting

confidence: 90%

Flow‐mediated dilatation in overweight and obese women with polycystic ovary syndrome

Brinkworth

Noakes

Moran

et al. 2006

BJOG

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“…Other exclusion criteria were breast feeding, hypertension (diastolic BP >95, systolic BP >150 mm Hg), vasoactive medication (including non-steroidal anti-inflammatory drugs, corticosteroids, lipid lowering agents, oral anticoagulants) and any history of peripheral vascular, cardiac, or polycystic ovarian disease. Ex-GDM subjects and controls were matched at recruitment for BMI [22, 23], age [24], and smoking [25, 26]. Other variables associated with alteration of endothelial function were also recorded.…”

Section: Subjectsmentioning

confidence: 99%

Vascular Function in Women with Previous Gestational Diabetes mellitus

et al. 2002

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It is hypothesised that vascular dysfunction, which characterises type 2 diabetes, may predate development of hyperglycaemia. 17 women with previous gestational diabetes mellitus, and thus at risk of developing type 2 diabetes, were matched with normal controls for body mass index, menstrual phase, smoking, age, blood pressure, and lipid profiles. All had normal glucose tolerance. Tests of microvascular and macrovascular function, including endothelium-dependent and -independent vasodilatation, were performed. Laser Doppler fluximetry of maximum skin microvascular hyperaemia in response to local heating of the dorsum of the foot to 42°C for 30 min was impaired in subjects compared to controls [subjects = 1.15 (0.73–1.73) V median (range) versus controls = 1.50 (0.95–2.29) V, p = 0.008]. There were no differences in laser Doppler perfusion imaging of responses to forearm skin iontophoresis of acetylcholine [subjects = 1.59 (0.32–2.55) V median (range) versus controls = 1.79 (0.72–2.06) V; p = 0.81] and sodium nitroprusside [subjects = 1.39 (0.8–3.14) V versus controls = 1.41 (0.34–2.19) V; p = 0.68], ultrasound estimation of brachial artery flow-mediated dilatation [subjects = 1.65 (–0.5–9.07)% versus controls = 2.77 (0.63–6.6)%; p = 0.42] and glyceryl trinitrate-induced dilatation [subjects = 15.20 (6.64–20.91)% versus controls = 15.92 (3.94–22.09)%; p = 0.48]. Microvascular maximum hyperaemia was impaired in the index group, suggesting the presence of a defect in vascular function. This defect was not explained by those aspects of endothelial function measured by the other techniques.

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“…This may be partly related to the fact that decreased circulating testosterone is often associated with aging [1], coupled with the fact that variables regulating blood flow may be somewhat compromised by aging [2].…”

Section: Introductionmentioning

confidence: 99%

Influence of a D-aspartic Acid/Sodium Nitrate/Vitamin D3 Dietary Supplement on Physiological Parameters in Middle-aged Men: A Pilot Study

Gunnels¹,

Moran²,

Schriefer³

2015

TONUTRAJ

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D-aspartic acid (DAA), nitrate, and vitamin D 3 have received considerable attention in recent years for their potential health-enhancing properties. Using an open-label design, we evaluated the impact of a DAA/sodium nitrate/ vitamin D 3 dietary supplement on blood testosterone and nitrate/nitrite, as well as subjective indicators of health, in middle-aged men.Methods: 10 overweight or obese men (mean age: 42 years) were assigned to ingest a DAA/sodium nitrate/ vitamin D 3 supplement (either one or two servings per day) for 28 days. Blood total and free testosterone and nitrate/nitrite was measured before and after 14 and 28 days of supplementation. Subjective assessment of to health indicators (e.g., energy level, libido) was included at each collection time.Results: Total and free testosterone increased on average 5-10%, which was not of statistical significance (p>0.05). The response was highly variable; some men failed to respond to treatment, while men with relatively low basal testosterone values experienced increases exceeding 20%. Plasma nitrate/nitrite was increased approximately 6-10 fold after treatment with the supplement, with a trend noted for a time effect (p=0.07). Men reported a significantly better feeling following supplement use, as evidenced by a time effect for both vitality (p=0.02) and libido (p=0.04), with a trend noted for increased energy level (p=0.08) and mental outlook and mood (p=0.10). Conclusion:Twenty-eight days of treatment with a DAA/sodium nitrate/ vitamin D 3 dietary supplement increased blood nitrate/nitrite and improved subjective feelings of vitality and libido in middle-aged men. In selected men with low basal testosterone values, the supplement increased circulating levels of this hormone.

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Age-Related Progressive Brachial Artery Endothelial Dysfunction Precedes the Changed Carotid and Left Ventricular Geometry in Healthy Humans

Cited by 13 publications

References 15 publications

Flow‐mediated dilatation in overweight and obese women with polycystic ovary syndrome

Flow‐mediated dilatation in overweight and obese women with polycystic ovary syndrome

Vascular Function in Women with Previous Gestational Diabetes mellitus

Influence of a D-aspartic Acid/Sodium Nitrate/Vitamin D3 Dietary Supplement on Physiological Parameters in Middle-aged Men: A Pilot Study

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