Age-related prefrontal cortex activation in associative memory: An fNIRS pilot study

Talamonti, Deborah; Montgomery, Catharine; Clark, Daniel P. A.; Bruno, Davide

doi:10.1016/j.neuroimage.2020.117223

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…The Hemispheric Asymmetry Reduction in Older adults (HAR-OLD) model [37] explained changes in brain activation with age-associated neurocognitive decline. Regarding the lateralization of DLPFC, right DLPFC activation was specific to young adults [38], while, in older adults, the activation was not only in the right DLPFC but also in the left DLPFC [38]. Our analyses revealed that the neural responses to optic flow stimuli were significantly higher in the right DLPFC than that in the left DLPFC in CU group, but not in AD-MCI group.…”

Section: Laterality Of Increased Brain Activities In Dlpfcmentioning

confidence: 57%

MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

et al. 2021

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Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion in the DLPFC in patients with mild cognitive impairment due to Alzheimer’s disease (AD-MCI) compared with cognitively unimpaired participants (CU). We analyzed the neural responses by evaluating maximum source-localized power for the AD-MCI group (n = 11) and CU (n = 20), focusing on six regions of interest (ROIs) that form the DLPFC: right and left dorsal Brodmann area 9/46 (A9/46d), Brodmann area 46 (A46) and ventral Brodmann area 9/46 (A9/46v). We found significant differences in the maximum power between the groups in the left A46 and A9/46v. Moreover, in the left A9/46v, the maximum power significantly correlated with the Wechsler Memory Scale-Revised general memory score and delayed recall score. The maximum power in the left A9/46v also revealed high performance in AD-MCI versus CU classification with the area under the ROC curve of 0.90. This study demonstrated that MEG during the optic flow task can be useful in discriminating AD-MCI from CU.

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Section: Laterality Of Increased Brain Activities In Dlpfcmentioning

confidence: 57%

MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

et al. 2021

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“…However, these findings have been inconsistent, with mixed lateralized activation patterns reported across different studies. Specifically, compared to low-performing older adults, high-performing older adults were found to exhibit more bilateral activation [ 24 ], or more unilateral activation on the brain hemisphere commonly known to specialize [ 25 , 27 ] (i.e., the left hemisphere for verbal tasks, the right hemisphere for visual tasks), but some studies have found the activation on the opposite side [ 26 ]. The inconsistent findings may be attributed to the varied differences in cognitive performance between the two groups across different studies.…”

Section: Introductionmentioning

confidence: 99%

Prefrontal hemodynamic features of older adults with preserved visuospatial working memory function

2023

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Memory decline has been observed in the aging population and is a risk factor for the later development of dementia. Understanding how memory is preserved in older adults has been an important topic. The present study examines the hemodynamic features of older adults whose memory is comparable with that of young adults. In the present study, 45 younger and 45 older adults performed the visual memory task with various difficulty levels (i.e., the items to be remembered), and their cerebral hemodynamics at each level were measured by functional near-infrared spectroscopy (fNIRS). The results showed that older adults exhibited higher activation than younger adults under more difficult but not easier levels. In addition, older adults whose performance is comparable with that of young adults (i.e., being able to remember six items) showed more right-lateralized activation. However, those unable to do so showed more left-lateralized activation. The results suggested that high-performing older adults possess successful compensatory mechanisms by recruiting cognitive resources in a specialized brain region.

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“…The current series of experiments aimed to explore whether temporal contiguity is an inherent feature of memory retrieval using both incidental and intentional learning tasks over a single trial (c.f., Hintzman, 2016 ). Following Curiel and Radvansky (1998) , our task can be completed successfully using either a temporal or a spatial strategy ( Talamonti et al, 2020 ). In Experiment 1, we presented stimuli around a spatial array and observed whether temporal or spatial clustering was employed at retrieval in a surprise free recall task.…”

Section: Introductionmentioning

confidence: 99%

Time is of the essence: Exploring temporal and spatial organisation in episodic memory

Clark

Bruno

2021

Quarterly Journal of Experimental Psychology

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There is disagreement in the literature as to whether episodic memory maintains an inherent temporal organisation, that is, whether learned items are necessarily organised along some temporal dimension or whether temporal organisation is a task-specific occurrence. The current series of experiments explored this issue. In Experiment 1, we tested whether temporal or spatial contiguity was present in an incidental encoding task where either strategy (but not both together) could be employed at test. In Experiment 2, we attempted to facilitate the use of a spatial retrieval strategy at test by asking participants to recall the location where target items had been displayed at study, after incidental encoding. Experiment 3 explored the role of study-test congruency by informing participants at encoding that they would be tested on either their memory for the temporal sequence or spatial locations, and then testing both at retrieval. Finally, Experiment 4 employed a masking task at encoding to ensure participants could not predict the true nature of the task, despite it being incidental, and a surprise free recall task. Predominantly, participants displayed recall performance consistent with temporal contiguity, although there was evidence for spatial contiguity under certain conditions. These results are consistent with the notion that episodic memory has a stable and predictable temporal organisation.

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Age-related prefrontal cortex activation in associative memory: An fNIRS pilot study

Cited by 7 publications

References 57 publications

MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

Prefrontal hemodynamic features of older adults with preserved visuospatial working memory function

Time is of the essence: Exploring temporal and spatial organisation in episodic memory

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