Age-related peridural hyperemia in craniosynostotic rabbits

Foley, Lesley M.; Fellows-Mayle, Wendy; Hitchens, T. Kevin; Losee, Joseph E.; Barbano, Timothy; Siegel, Michael I.; Mooney, Mark P.

doi:10.1007/s00381-009-0812-z

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…Furthermore, we demonstrated that early surgical correction mitigated adverse changes in the white matter tissue microstructure, with no statistically significant differences found in quantitative DTI parameters between surgically corrected and age-matched control animals. This study adds new evidence to the existing sequelae of craniosynostosis in the rabbit model, including decreased brain growth 5 and intracranial volume, 6 surface cortex blood flow anomalies, 16 and hyperactivity with early reflexive behavior in the early stages of life. 21 …”

Section: Discussionmentioning

confidence: 74%

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

Bonfield

Foley²,

Kundu³

et al. 2015

FOC

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OBJECT Craniosynostosis is a condition in which one or more of the calvarial sutures fuses prematurely. In addition to the cosmetic ramifications attributable to premature suture fusion, aberrations in neurophysiological parameters are seen, which may result in more significant damage. This work examines the microstructural integrity of white matter, using diffusion tensor imaging (DTI) in a homogeneous strain of rabbits with simple, familial coronal suture synostosis before and after surgical correction. METHODS After diagnosis, rabbits were assigned to different groups: wild-type (WT), rabbits with early-onset complete fusion of the coronal suture (BC), and rabbits that had undergone surgical correction with suturectomy (BC-SU) at 10 days of age. Fixed rabbit heads were imaged at 12, 25, or 42 days of life using a 4.7-T, 40-cm bore Avance scanner with a 7.2-cm radiofrequency coil. For DTI, a 3D spin echo sequence was used with a diffusion gradient (b = 2000 sec/mm2) applied in 6 directions. RESULTS As age increased from 12 to 42 days, the DTI differences between WT and BC groups became more pronounced (p < 0.05, 1-way ANOVA), especially in the corpus callosum, cingulum, and fimbriae. Suturectomy resulted in rabbits with no significant differences compared with WT animals, as assessed by DTI of white matter tracts. Also, it was possible to predict to which group an animal belonged (WT, BC, and BC-SU) with high accuracy based on imaging data alone using a linear support vector machine classifier. The ability to predict to which group the animal belonged improved as the age of the animal increased (71% accurate at 12 days and 100% accurate at 42 days). CONCLUSIONS Craniosynostosis results in characteristic changes of major white matter tracts, with differences becoming more apparent as the age of the rabbits increases. Early suturectomy (at 10 days of life) appears to mitigate these differences.

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Section: Discussionmentioning

confidence: 74%

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

Bonfield

Foley²,

Kundu³

et al. 2015

FOC

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“…Pioneer work by Virchow showed that the primary defect lies within the suture that is later translated to the cranial base by an unknown mechanism [12]. Moss then postulates that the cranial base is the source of the primary defect, which translates its effects on the suture through the dura mater [13].…”

Section: Discussionmentioning

confidence: 99%

Role of^99mTc-ECD SPECT in the Management of Children with Craniosynostosis

Barik

Bajpai

Das

et al. 2014

BioMed Research International

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Purpose of the Report. There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of 99mTc-ECD SPECT in a large number of subjects with craniosynostosis. Materials and Methods. We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with 99mTc-ECD SPECT and the results were correlated with radiological and surgical findings. Results. 99mTc-ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly (P < 0.05) postoperatively only in those children with absent perfusion defect postoperatively. Conclusions. Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on 99mTc-ECD SPECT study) are beneficial, as theylead to improved MPQ after surgery.

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“…This study used a breeding colony of New Zealand white rabbits with naturally occurring coronal suture synostosis [ 15 , 21 – 25 ]. All rabbits were born and maintained in the vivarium at the Department of Anthropology, University of Pittsburgh and housed in stainless steel cages with access to food and water ad libitum.…”

Section: Methodsmentioning

confidence: 99%

“…CBF was studied in EOCS rabbits at 10, 25 and 42 days of age using ASL-MRI. A previous study from our group revealed CBF to be similar between wild-type (WT) and EOCS subjects, with the exception of the superficial cortex surfaces in EOCS rabbits at 25 days of age [ 25 ]. A two-fold increase in superficial cortex CBF at 25 days of age was noted.…”

Section: Introductionmentioning

confidence: 99%

“…We used ASL-MRI to show the age-related changes in CBF, comparing wild-type subjects, and EOCS subjects with and without suturectomy over various time points. In light of the previous studies showing age-related increased ICP and CBF in rabbits with craniosynostosis and the prevention of early increased ICP via suturectomy [ 9 , 12 , 24 , 25 ], we investigated the hypothesis that early suturectomy in rabbits with bicoronal craniosynostosis will result in the abolishment of the age-related increase in CBF seen in the ipsilateral superficial cortical surfaces of our rabbit craniosynostosis model. By analyzing the differences in cerebral blood flow seen over time in subjects undergoing suturectomy versus those that do not undergo suturectomy, one may obtain clinically-relevant information and potentially determine whether a critical period exists during which suturectomy is indicated to prevent a cascade of changes in neurophysiologic parameters that may result in secondary brain injury.…”

Section: Introductionmentioning

confidence: 99%

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The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis

et al. 2018

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BackgroundCoronal suture synostosis is a condition which can have deleterious physical and cognitive sequelae in humans if not corrected. A well-established animal model has previously demonstrated disruptions in intracranial pressure and developmental abnormalities in rabbits with congenital craniosynostosis compared to wild type rabbits.ObjectiveThe current study aimed to measure the cerebral blood flow (CBF) in developing rabbits with craniosynostosis who underwent suturectomy compared to those with no intervention and compared to wild type rabbits.MethodsRabbits with early onset coronal suture synostosis were assigned to have suturectomy at 10 days of age (EOCS-SU, n = 15) or no intervention (EOCS, n = 18). A subset of each group was randomly selected for measurement at 10 days of age, 25 days of age, and 42 days of age. Wild type rabbits (WT, n = 18) were also randomly assigned to measurement at each time point as controls. Cerebral blood flow at the bilateral hemispheres, cortices, thalami, and superficial cortices was measured in each group using arterial spin-labeling MRI.ResultsAt 25 days of age, CBF at the superficial cortex was significantly higher in EOCS rabbits (192.6 ± 10.1 mL/100 mg/min on the left and 195 ± 9.5 mL/100 mg/min on the right) compared to WT rabbits (99.2 ± 29.1 mL/100 mg/min on the left and 96.2 ± 21.4 mL/100 mg/min on the right), but there was no significant difference in CBF between EOCS-SU (97.6 ± 11.3 mL/100 mg/min on the left and 99 ± 7.4 mL/100 mg/min on the right) and WT rabbits. By 42 days of age the CBF in EOCS rabbits was not significantly different than that of WT rabbits.ConclusionSuturectomy eliminated the abnormally increased CBF at the superficial cortex seen in EOCS rabbits at 25 days of age. This finding contributes to the evidence that suturectomy limits abnormalities of ICP and CBF associated with craniosynostosis.

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Age-related peridural hyperemia in craniosynostotic rabbits

Cited by 5 publications

References 35 publications

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

Role of^99mTc-ECD SPECT in the Management of Children with Craniosynostosis

The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis

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Age-related peridural hyperemia in craniosynostotic rabbits

Cited by 5 publications

References 35 publications

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis

Role of99mTc-ECD SPECT in the Management of Children with Craniosynostosis

The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis

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Role of^99mTc-ECD SPECT in the Management of Children with Craniosynostosis