Age-related pattern of KI and WU polyomavirus infection

Abstract

This study supports previous conclusions that KIV and WUV detection in the respiratory tract may be coincidental and reflect reactivation of latent or persistent infection with these viruses. The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC.

Secondary lymphoid tissue as an important site for WU polyomavirus infection in immunocompetent children

“…A pattern of infection that is similar to that of the well-known JC and BK polyomaviruses (JCV and BKV) has emerged, which suggests primary exposure to the virus during childhood, after which infection is sustained by close inter-human contacts [Abedi Kiasari et al, 2008;Kean et al, 2009].…”

KIPolyomavirus Sequenses in Respiratory Specimens from Bulgarian Children

“…there is still scarce information about the tropism of Ki PyV. to date Ki PyV has been isolated from respiratory secretions and stool (1) and from sewage (8), showing that the most probable routes of infection are respiratory and alimentary. in contrast to other polyomaviruses (BK and Jc), Ki has not been detected in blood and urine, nor has been isolated from brain tumours of immunocompetent patients (12).…”

“…Studies that included such a control group, detected viral sequences in asymptomatic patients with a similar prevalence. linking the infection with Ki PyV and respiratory diseases is further complicated by the observed high rates of co-infection with other respiratory viruses (1,2,7,11,17). Despite the lack of evidence that Ki PyV causes human disease, additional research is warranted to investigate this possibility, especially when considering the similarities of Ki PyV to BK and Jc in terms of nucleotide sequence and potential route of infection.…”

Characterising the pathogenesis and biology of newly described human polyomaviruses

“…PCR detection rates for WUPyV and KIPyV in respiratory secretions are between 0.4 -9% in studies conducted throughout the world. [6], [7], [115]- [132] Higher detection rates have been noted in immunocompromised populations. However most reports have been conducted using small cohorts and lack appropriate control populations.…”

“…However they have also been found in blood, faeces and lymphoid tissues. [115], [120], [133]- [137] Co-detection with other respiratory pathogens is common making it difficult to determine an aetiological link between KIPyV and WUPyV infection and respiratory disease. [6], [7], [129], [131], [133], [138], [139] Different studies show that the seroprevalance of WUPyV and KIPyV range between 54%-90% and 55%-93.3% in healthy adults respectively.…”