Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

Leidhin, Caoilfhionn Ní; McMorrow, Jason P.; Carey, Daniel; Newman, Louise; Williamson, Wilby; Fagan, Andrew; Chappell, Michael A.; Kenny, Rose Anne; Meaney, James; Knight, Silvin P.

doi:10.1016/j.neuroimage.2021.117741

Cited by 20 publications

(23 citation statements)

References 47 publications

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“…Consistent with prior studies using various imaging modalities,( Chen et al., 2011 ; Leidhin et al., 2021 ; Liu et al., 2012 ; Lu et al., 2011 ; Parkes et al., 2004 ; Selim et al., 2008 ; Wolters et al., 2017 ; Zhang et al., 2018 ) in the present study an age-related decrease in CBF GM was found for all models. Direct comparison between the present work and previous studies is limited due to significant differences in methodologies.…”

Section: Discussionsupporting

confidence: 93%

“…Sex differences were observed in most models (with the exception of the multivariable continuous WHR model (model 2.b)); this is not unexpected and is in line with previous studies where it was likewise found that global CBF was increased in women. ( Leidhin et al., 2021 ; Liu et al., 2012 ; Zhang et al., 2018 ) Indeed, in a recent study reporting normative CBF GM values stratified by sex, not only were women found to have higher CBF GM overall on average, as reported herein, but also a slower decline in CBF GM between the ages of 54 and 84 years. ( Leidhin et al., 2021 ) Additionally, normative brain volume values from the Framingham Heart study reported sex differences in brain volumes, with women having modestly larger total brain and frontal lobe volumes (normalized to head size) across all age groups investigated, as well as larger volumes of white matter hyperintensities.…”

Section: Discussionsupporting

confidence: 62%

“…( Leidhin et al., 2021 ; Liu et al., 2012 ; Zhang et al., 2018 ) Indeed, in a recent study reporting normative CBF GM values stratified by sex, not only were women found to have higher CBF GM overall on average, as reported herein, but also a slower decline in CBF GM between the ages of 54 and 84 years. ( Leidhin et al., 2021 ) Additionally, normative brain volume values from the Framingham Heart study reported sex differences in brain volumes, with women having modestly larger total brain and frontal lobe volumes (normalized to head size) across all age groups investigated, as well as larger volumes of white matter hyperintensities. Also, similar to CBF, males were reported as having a faster decline in brain volume over time.…”

Section: Discussionsupporting

confidence: 59%

See 2 more Smart Citations

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Knight

Laird

Williamson

et al. 2021

Neurobiology of Aging

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 59%

See 1 more Smart Citation

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Knight

Laird

Williamson

et al. 2021

Neurobiology of Aging

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“…A recent longitudinal study of 468 older people reported average CBF across the age range 50-90 [37]. The average GM CBF at age 69 is reported as 38.2 ml/min/100g for women and 34.8 ml/ min/100g for men [37], both of which are comparable with our values (37.4 ml/min/100g for women, 31.5 ml/min/100g for men, Table 2).…”

Section: Discussionsupporting

confidence: 89%

Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease

Binnie

Pauls

Benjamin

et al. 2022

Transl. Stroke Res.

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Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter.Here we quantified test–retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days).Test–retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM).We conclude that pCASL has high test–retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint.All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015).

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“…Our study also has potential limitations, for example in the individuation of outliers in the distribution of single trial mistakes across all participants. Many studies [ 73 , 74 ] prefer to remove outliers present in a distribution, because this is not considered to be a good representation of the sample population. However, our analyses demonstrated that, although the subset of participants individuated by the new threshold was relatively small compared to the entire sample, it could serve for the prediction of mobility decline with a good statistical power, and even better than traditional global parameters usually used to characterize the mistakes in SART performances.…”

Section: Discussionmentioning

confidence: 99%

SART and Individual Trial Mistake Thresholds: Predictive Model for Mobility Decline

et al. 2021

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The Sustained Attention to Response Task (SART) has been used to measure neurocognitive functions in older adults. However, simplified average features of this complex dataset may result in loss of primary information and fail to express associations between test performance and clinically meaningful outcomes. Here, we describe a new method to visualise individual trial (raw) information obtained from the SART test, vis-à-vis age, and groups based on mobility status in a large population-based study of ageing in Ireland. A thresholding method, based on the individual trial number of mistakes, was employed to better visualise poorer SART performances, and was statistically validated with binary logistic regression models to predict mobility and cognitive decline after 4 years. Raw SART data were available for 4864 participants aged 50 years and over at baseline. The novel visualisation-derived feature bad performance, indicating the number of SART trials with at least 4 mistakes, was the most significant predictor of mobility decline expressed by the transition from Timed Up-and-Go (TUG) < 12 to TUG ≥ 12 s (OR = 1.29; 95% CI 1.14–1.46; p < 0.001), and the only significant predictor of new falls (OR = 1.11; 95% CI 1.03–1.21; p = 0.011), in models adjusted for multiple covariates. However, no SART-related variables resulted significant for the risk of cognitive decline, expressed by a decrease of ≥ 2 points in the Mini-Mental State Examination (MMSE) score. This novel multimodal visualisation could help clinicians easily develop clinical hypotheses. A threshold approach to the evaluation of SART performance in older adults may better identify subjects at higher risk of future mobility decline.

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Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

Cited by 20 publications

References 47 publications

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease

SART and Individual Trial Mistake Thresholds: Predictive Model for Mobility Decline

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