Age‐related morphology trends of cortical sulci

Kochunov, Peter; Mangin, Jean François; Coyle, Thomas R.; Lancaster, Jack L.; Thompson, Paul M.; Rivière, D.; Yann, C.; Régis, Jean; Schlosser, A. E.; Royall, Donald R.; Zilles, Karl; Mazziotta, John C.; Toga, Arthur W.; Fox, Peter T.

doi:10.1002/hbm.20198

Cited by 199 publications

(208 citation statements)

References 38 publications

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“…Reduced cortical gyrification with increasing age may be due to reduced sulcal depth (Kochunov et al, 2005). In a study of gyrification in healthy adults aged between 20 and 85 years, lGI was negatively correlated with age in all major lobes of the brain, including regions in which groups differed in the present study (Hogstrom et al, in press).…”

Section: Relationship With Agesupporting

confidence: 48%

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Nesvåg

Schaer

Haukvik

et al. 2014

Schizophrenia Research

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The cerebral cortex is highly convoluted, and principal folding patterns are determined early in life. Degree of cortical folding in adult life may index aberrations in brain development. Results from previous studies of cortical folding in schizophrenia are inconsistent. Here we investigated cortical folding patterns in the hitherto largest sample of patients with schizophrenia drawn from two independent cohorts. Magnetic resonance imaging scans were acquired from 207 patients and 206 healthy subjects recruited to two separate research projects in Sweden and Norway. Local gyrification index (lGI) was estimated continuously across the cortex using automated methods. Group differences in lGI were analyzed using general linear models. Patients had lower lGI in three large clusters of the cortex with peak differences found in the left precentral gyrus, right middle temporal gyrus, and right precuneus. Similar, although not completely overlapping results were found when the two cohorts were analyzed separately. There were no significant interaction effects between age and diagnosis and gender and diagnosis. The finding of reduced degree of folding in large regions of the cerebral cortex across two independent samples indicates that reduced gyrification is an inherent feature of the brain pathology in schizophrenia.

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Section: Relationship With Agesupporting

confidence: 48%

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Nesvåg

Schaer

Haukvik

et al. 2014

Schizophrenia Research

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“…On an another study by Peter Kochunov (3) at Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas found highly significant increase in sulcal width and decrease in sulcal depth with age were observed.…”

Section: Review Of Literaturementioning

confidence: 97%

Ct Study Comparing Sulcal Changes and Third Ventricle Size as Age Progresses From 40 to 80

George¹,

Manuel²,

Mohan³

et al. 2014

jemds

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INTRODUCTION:Computerized tomography, also called CT combines a series of X-ray views taken from many different angles and computer processing to create cross-sectional images of the bones and soft tissues inside your body. It has brought about tremendous changes in the field of diagnostic and research medicine. Here CT is used to measure the various dimensions of 6 selected sulci of brain and third ventricle. With the recent advances in technology, sulcal pattern and development is being studied extensively to understand the functioning of brain. There is evidence of sulcal dimensional changes as age of an individual progress. This may be responsible for behavioral or intellectual changes in a individual. Through this study I intend to understand how the sulcal dimension may vary with the help of CT scans. 6 sulci were selected and their width was measured in 80 individuals between the age group of 40 and 80. Through statistical analysis the data will reveal any recognizable changes in the width of the selected sulcus with progression of age. The third ventricle size may also be influenced by the age of the individual. Using the help of CT scan I am intending to measure the dimensions of the third ventricle. Recent studies have shown that size and volume of the third ventricle have significant role in the geriatric population. AIMS AND OBJECTIVES: To study the age related changes in the width of left and right central sulcus, superior temporal sulcus, parieto-occipital sulcus and to study the age related changes in third ventricle depth, length and width through the use of CT scans. STUDY SETTINGS: A cross-sectional study comprising of 60 patients coming to the radiology department for the C T scan. The CT scans for the study were taken randomly between the ages of 40 to 80. RESULTS: The purpose of the study was to study the changes in the dimensions of sulci and the third ventricle of the brain. Hypothesis was that the sulcal width increases with advance in age. the objective was to analyze the data from CT scans and bring out the variation in sulcal depth and third ventricle. Positive correlations were noted in the width of right central sulcus, left and right superior frontal sulcus, right and left parieto-occipital sulcus and width of the third ventricle. No relationship was noted between age and the width of left central sulcus, depth and length of third ventricle.

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“…This change in geometry of cortical folding with aging can lead to cognitive decline and is probably due to loss of grey matter which leads to thinning and widening of the cortical sulci, also causing a secondary widening of the ventricles of the brain 15,16 .…”

Section: Discussionmentioning

confidence: 99%

A Computerised Tomographic assessment of structural changes in the human brain with aging

Meka

Taranikanti

Devarashetty

et al. 2014

Int Jour of Biomed Res

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Age‐related morphology trends of cortical sulci

Cited by 199 publications

References 38 publications

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Ct Study Comparing Sulcal Changes and Third Ventricle Size as Age Progresses From 40 to 80

A Computerised Tomographic assessment of structural changes in the human brain with aging

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