Age-related microvascular degeneration in the human cerebral periventricular white matter

Farkas, Eszter; Vos, Rob A. I. de; Donka, Gergely; Steur, Enhj; Mihály, András; Luiten, P.G.M.

doi:10.1007/s00401-005-0007-y

Cited by 85 publications

(74 citation statements)

References 57 publications

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“…[26][27][28] Histologic studies have also demonstrated that vessel narrowing and/or outright vessel loss occurs with advancing age. 11,29,30 Although these histologic studies generally address vessels of a diameter smaller than can be seen by MRA, both a reduction in vessel number and/or a reduction in vessel lumen could reduce the number of vessels detected by MRA. In general, MRA cannot distinguish overt vessel loss and the loss of visualizable vessels as a result of decreased flow rate.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

Bullitt¹,

Rahman²,

Ja³

et al. 2009

AJNR Am J Neuroradiol

119

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BACKGROUND AND PURPOSE:Prior studies suggest that aerobic exercise may reduce both the brain atrophy and the decline in fractional anisotropy observed with advancing age. It is reasonable to hypothesize that exercise-induced changes to the vasculature may underlie these anatomic differences. The purpose of this blinded study was to compare high-activity and low-activity healthy elderly volunteers for differences in the cerebrovasculature as calculated from vessels extracted from noninvasive MR angiograms (MRAs).

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Section: Discussionmentioning

confidence: 99%

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

Bullitt¹,

Rahman²,

Ja³

et al. 2009

AJNR Am J Neuroradiol

119

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“…The BM also suffers changes along aging, becoming thicker as age increases [138,139]. Interestingly, this alteration also occurs, and is even more evident, in AD [140].…”

Section: Impairment Of Blood-brain Barrier Properties In Agingmentioning

confidence: 94%

Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease

2015

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Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline that afflicts as many as 45 % of individuals who survive past the age of 85. AD has been associated with neurovascular dysfunction and brain accumulation of amyloid-β peptide, as well as tau phosphorylation and neurodegeneration, but the pathogenesis of the disease is still somewhat unclear. According to the amyloid cascade hypothesis of AD, accumulation of amyloid-β peptide (Aβ) aggregates initiates a sequence of events leading to neuronal injury and loss, and dementia. Alternatively, the vascular hypothesis of AD incorporates the vascular contribution to the disease, stating that a primary insult to brain microcirculation (e.g., stroke) not only contributes to amyloidopathy but initiates a non-amyloidogenic pathway of vascular-mediated neuronal dysfunction and injury, which involves blood-brain barrier compromise, with increased permeability of blood vessels, leakage of blood-borne components into the brain, and, consequently, neurotoxicity. Vascular dysfunction also includes a diminished brain capillary flow, causing multiple focal ischemic or hypoxic microinjuries, diminished amyloid-β clearance, and formation of neurotoxic oligomers, which lead to neuronal dysfunction. Here we present and discuss relevant findings on the contribution of vascular alterations during aging to AD, with the hope that a better understanding of the players in the "orchestra" of neurodegeneration will be useful in developing therapies to modulate the "symphony".

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“…10 Histopathologic analysis of abnormal white matter shows venular intramural collagen deposition leading to wall-thickening stenosis. 11 The vascular anatomy of the white matter provides an intrinsically higher vascular resistance compared with the cortex.…”

mentioning

confidence: 99%

Vascular Dysfunction in Leukoaraiosis

Sam

Crawley

Poublanc

et al. 2016

AJNR Am J Neuroradiol

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Age-related microvascular degeneration in the human cerebral periventricular white matter

Cited by 85 publications

References 57 publications

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease

Vascular Dysfunction in Leukoaraiosis

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