Age-related macular degeneration: review of current treatments

Poley, Preeti Rebecca; Stapleton, W. M.; Qui, Fang; Mulhern, Michael L.; Ingvoldstad, David D; Margalit, Eyal

doi:10.1586/eop.11.6

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…In wet AMD, selected cases may be suitable for medical treatment with anti-vascular growth factor injections, that aim to slow the progression of the disease and vision loss (e.g. intravitreal injections), 5,14 but the treatment cannot revert vision to a pre-diagnosis state.…”

Section: Consequences Of Age-related Macular Degenerationmentioning

confidence: 99%

Low Vision Devices for Age-Related Macular Degeneration: A Systematic Review

Macnamara¹,

Chen²,

Davies³

et al. 2021

Preprint

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Significance: Age-related macular degeneration (AMD) is a degenerative condition impacting central vision. Evaluating the effectiveness of low vision devices provides empirical evidence on how devices can overcome deficits caused by AMD and facilitates discussion on future improvements to vision enhancement technology.Methods: A systematic review of the literature was conducted on the use of low vision devices in AMD populations. Relevant peer-reviewed research articles from six databases were screened.Results: The findings of thirty-five studies revealed a significant impact of low vision devices leading to improvements in visual acuity, reading performance, facial recognition, and more. While the studies were generally found to have a moderate risk of bias, a GRADE assessment of the evidence suggests that the general certainty of the evidence was low-moderate.Conclusions: A positive effect of low vision devices was found for visual acuity, reading performance, facial recognition, and more. Simple low vision devices (e.g. magnifiers) appear to currently have greater preferential support than newer, visual enhancement technology (e.g. head mounted devices). Factors influencing this were discussed relative to low vision device features, the AMD demographic, and financial considerations. This is compounded by a lack of studies examining newer technologies in AMD populations, which future research should address. Moreover, given the presence of bias across the studies, heighted by limited controlled experiments, there may be inadequate confidence in the results. So, even though low vision devices are reported to be a valuable asset to AMD populations, more rigorous research is required to draw conclusive evidence.

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Section: Consequences Of Age-related Macular Degenerationmentioning

confidence: 99%