Age-Related Macular Degeneration and Extramacular Drusen: Genetic Associations in the Coimbra Eye Study
Cláudia Farinha,
Patrícia Barreto,
Rita Coimbra
et al.
Abstract:To explore the association between the genetics of age-related macular degeneration (AMD) and extramacular drusen (EMD) in patients with and without AMD.
METHODS.We included 1753 eyes (912 subjects) with phenotypic characterization regarding AMD and EMD. Genetic sequencing and the genetic risk score (GRS) for AMD were performed according to the EYE-RISK consortium methodology. To test for differences in the GRS from EMD cases, AMD cases, and controls, a clustered Wilcoxon rank-sum test was used. The associatio… Show more
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