Age-Related Macular Degeneration

Fine, Stuart L.; Berger, Jeffrey W.; Maguire, Maureen G.; Ho, Allen C.

doi:10.1056/nejm200002173420707

Cited by 401 publications

(292 citation statements)

References 58 publications

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“…Wet ARMD is characterized by the presence of choroidal neovascularization with disciform scar representing the end stage. 2 Several risk factors such as cigarette smoking, sunlight exposure, obesity, hypertension, and hypercholesterolaemia have been associated with the development of ARMD. 3 In exudative ARMD the formation of choroidal neovascular membrane (CNV) has been attributed to the elaboration of growth factors, cytokines, and proteases.…”

Section: Introductionmentioning

confidence: 99%

Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration

Coral

Raman

Rathi

et al. 2005

Eye

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Purpose Exudative age-related macular degeneration (ARMD) is one of the debilitating ocular complications, which results in permanent blindness. Elevated homocysteine (Hcys) levels have been associated in the development of several vascular diseases. Vascular and oxidative stress theories have been implicated for the development of choroidal neovascularization in exudative ARMD. The aim of the present study was to investigate the possible role of plasma Hcys and thiol content (tSH) as a risk factor for the development of exudative ARMD. Method A total of 16 patients with exudative ARMD and 20 age-matched controls were recruited for the study. Plasma Hcys levels were analysed using Reverse Phase High Performance Liquid Chromatography. Plasma glutathione (GSH) content was determined using o-phthalaldehyde (OPA) derivatization and subsequent detection by fluorimeter. Plasma tSH levels were determined by using thiol-specific reagent dithionitrobenzoic acid (DTNB) spectrophotometrically. Results Plasma Hcys levels in exudative ARMD were elevated three-fold (1875.0 lM) when compared to healthy controls (6.771.8 lM). There was a two-fold decrease in the GSH and tSH in exudative ARMD when compared with controls. Negative correlation was observed between diminished tSH and Hcys levels (r ¼ À0.4837, P ¼ 0.05). Similarly plasma Hcys levels negatively correlated with GSH content (r ¼ À0.6620, Po0.05). Conclusion Results from our present study revealed that there is an elevated Hcys level and diminished thiol pool content in exudative ARMD that are significant.

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Section: Introductionmentioning

confidence: 99%

Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration

Coral

Raman

Rathi

et al. 2005

Eye

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“…Each RPE cell serves 50 cones or rods, and, therefore, each day an RPE cell metabolizes photopsin membranes of about five cones or rods, demonstrating a very high metabolic activity. Photoreceptor cells cannot survive without the macrophagic activity of RPE (Fine et al 2000;Jager et al 2008).…”

Section: Photoreceptor Nervous Cellsmentioning

confidence: 99%

“…Above all, this is manifested in the functionality of the most sensitive part of the retina, the macula-where the accumulation of A2E is most abundant (Sparrow 2003;Ablonczy et al 2012)-from which the name "age-related macular degeneration" (AMD) comes (Fine et al 2000).…”

Section: Photoreceptor Nervous Cellsmentioning

confidence: 99%

Aging of perennial cells and organ parts according to the programmed aging paradigm

Libertini

Ferrara

2016

AGE

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If aging is a physiological phenomenon-as maintained by the programmed aging paradigm-it must be caused by specific genetically determined and regulated mechanisms, which must be confirmed by evidence. Within the programmed aging paradigm, a complete proposal starts from the observation that cells, tissues, and organs show continuous turnover: As telomere shortening determines both limits to cell replication and a progressive impairment of cellular functions, a progressive decline in age-related fitness decline (i.e., aging) is a clear consequence. Against this hypothesis, a critic might argue that there are cells (most types of neurons) and organ parts (crystalline core and tooth enamel) that have no turnover and are subject to wear or manifest alterations similar to those of cells with turnover. In this review, it is shown how cell types without turnover appear to be strictly dependent on cells subjected to turnover. The loss or weakening of the functions fulfilled by these cells with turnover, due to telomere shortening and turnover slowing, compromises the vitality of the served cells without turnover. This determines well-known clinical manifestations, which in their early forms are described as distinct diseases (e.g., Alzheimer's disease, Parkinson's disease, age-related macular degeneration, etc.). Moreover, for the two organ parts (crystalline core and tooth enamel) without viable cells or any cell turnover, it is discussed how this is entirely compatible with the programmed aging paradigm.

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“…A prevalência da DMRI aumenta proporcionalmente à idade, afetando 11.5% das pessoas brancas com idade acima de 80 anos (1) . Estima-se que 1 milhão e seiscentos mil americanos apresentam esta doença e que, devido ao aumento da expectativa de vida da população, este número possa dobrar nos próximos 30 anos (2)(3)(4) . A importância epidemiológica da doença resultou em inúmeras pesquisas e tratamentos preventivos para se tentar evitar a instalação e/ou progressão desta grave patologia ocular A DMRI é uma doença multifatorial (5)(6) .…”

Section: Introductionunclassified

Conceitos atuais e perspectivas na prevenção da degeneração macular relacionada à idade

Torres¹,

Précoma²,

Maia³

et al. 2008

Rev. bras.oftalmol.

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Age-Related Macular Degeneration

Cited by 401 publications

References 58 publications

Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration

Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration

Aging of perennial cells and organ parts according to the programmed aging paradigm

Conceitos atuais e perspectivas na prevenção da degeneração macular relacionada à idade

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