Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

Hamrick, Mark W.; Ding, Ke; Pennington, Catherine; Chao, Yuh J.; Wu, Yii Der; Howard, Boyd; Immel, David; Borlongan, Cesario V.; McNeil, Paul L.; Bollag, Wendy B.; Curl, Walton W.; Yu, Jack C.; Isales, Carlos M.

doi:10.1016/j.bone.2006.04.011

Cited by 135 publications

(136 citation statements)

References 33 publications

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“…At the age of 24 months, muscle volume changes might also occur and influence body weight and plasma adipokine levels. This was illustrated by a study by Hamrick et al [8]. They found a statistical significant decline in hind limb muscle mass and bone tissue in male C57BL/6J mice between the ages of 18 and 24 months and in addition, these changes were associated with a decrease in serum leptin levels.…”

Section: Discussionmentioning

confidence: 85%

Age-associated adaptations in murine adipose tissues

et al. 2010

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Adipose tissue development is a highly organized process, that involves either hypertrophy (enlargement of existing adipocytes) or hyperplasia (increase in the number of mature adipocytes) or a combination of both [1]. White adipose tissue (WAT) is a major endocrine and secretory organ, releasing fatty acids, different lipid moieties and a multiplicity of adipokines [2].Ageing has been associated with an increase in visceral obesity in both men and women, putting the elderly population at a high risk to develop age-associated diseases such as hypertension, dyslipidemia, insulin resistance, type 2 diabetes, metabolic syndrome and cardiovascular disease [3]. Over the last decades, wildtype C57Bl/6 mice of different age range have been extensively used in studies on obesity and metabolic syndrome. However, little information is available on Age-associated adaptations in murine adipose tissues Abstract. Ageing is associated with an increase in visceral obesity in men and women. Although wild-type mice with a C57Bl/6 genetic background are extensively used in studies on obesity and metabolism, little information is available on age-associated changes in their adipose tissues. We have evaluated development and composition of subcutaneous (SC) and gonadal (GON) adipose tissue in male C57Bl/6 mice at the ages of 10 weeks, 12 months or 24 months, while kept on normal chow. Total body weight as well as SC and GON fat mass significantly increased between 10 weeks and 12 months, but markedly decreased again up to 24 months of age. Adipocyte size in both fat depots and blood vessel size in GON fat followed this trend. Plasma leptin levels correlated positively with body weight and SC or GON fat mass. Both 12 and 24 months old mice displayed better insulin sensitivity as compared to 10 weeks old counterparts, reflected by significantly decreased plasma levels of insulin and/or glucose. Thus, ageing of C57Bl/6 male mice is associated with a biphasic pattern (increase up to 12 months followed by a decrease up to 24 months) of body weight, SC and GON fat mass, adipocyte and blood vessel size.

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Section: Discussionmentioning

confidence: 85%

Age-associated adaptations in murine adipose tissues

et al. 2010

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“…Hence, cognitive impairment associated with masticatory dysfunction might result, in part, from diminished activity of the sensory pathways caused by reduced mastication. In elderly patients, the hippocampus does not receive sufficient inputs to maintain hippocampal function due to reduced locomotor activity and decreased input/function of the peripheral sensory organs compared to young subjects 42,43) , thereby leading to a gradual decline in learning and memory. Thus, sensory input from masticatory organs appears to have an important role in maintaining cognitive function, especially in the aged hippocampus.…”

Section: Effect Of Dysfunctional Mastication On Cognitive Functionmentioning

confidence: 99%

Masticatory function and cognitive function

Kubo

Ichihashi²,

Kurata³

et al. 2010

Okajimas Folia Anat. Jpn.

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“…(11) We and others have previously shown that the C57BL/6 mouse is a valid model to study age-induced bone loss. (12)(13)(14) These mice begin to lose bone after 18 mo of age and have large drops in bone mass by 29 mo of age. (14) Because of the well-established association between nutrition and aging (e.g., reduced nutrient intake in the form of caloric restriction is the countermeasure most consistently shown to prolong lifespan), we hypothesized that the GIP Tg + mice would be protected from age-induced bone loss.…”

Section: G Lucose-dependent Insulinotropic Peptide (Gip) Ismentioning

confidence: 99%