Age-related loss of auditory sensitivity in the zebrafish (Danio rerio)

Zeng, Ruiyu; Brown, Andrew D.; Rogers, Loranzie S.; Lawrence, Owen; Clark, John I.; Sisneros, Joseph A.

doi:10.1016/j.heares.2021.108189

Cited by 7 publications

(7 citation statements)

References 70 publications

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“…However, prior work shows a strong correlation between saccular hair cell density and auditory thresholds in multiple species of fish, including zebrafish 23 , 57 . Wang et al 27 demonstrated age-related threshold shifts in 16 to 20-month-old zebrafish and Zeng et al 28 noted a threshold shift at 37 months, but not at 20 months. Wang et al used inbred AB zebrafish, while Zeng et al used an outbred line (AB/WIK cross).…”

Section: Discussionmentioning

confidence: 99%

“…In the past few decades, zebrafish ( Danio rerio ) have emerged as an exciting model organism for studies of inner ear development, hearing loss and protection, and hair cell regeneration 19 , 25 , 26 . Despite their regenerative abilities, recent studies show that zebrafish exhibit age-related auditory deficits, including increased auditory thresholds and a decline in the number of hair cells in the saccule (primary auditory organ) 27 , 28 . However, the mechanisms underlying ARHL in zebrafish are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in the zebrafish and killifish inner ear and lateral line

Coffin,

Dale,

Molano

et al. 2024

Sci Rep

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Age-related hearing loss (ARHL) is a debilitating disorder for millions worldwide. While there are multiple underlying causes of ARHL, one common factor is loss of sensory hair cells. In mammals, new hair cells are not produced postnatally and do not regenerate after damage, leading to permanent hearing impairment. By contrast, fish produce hair cells throughout life and robustly regenerate these cells after toxic insult. Despite these regenerative abilities, zebrafish show features of ARHL. Here, we show that aged zebrafish of both sexes exhibited significant hair cell loss and decreased cell proliferation in all inner ear epithelia (saccule, lagena, utricle). Ears from aged zebrafish had increased expression of pro-inflammatory genes and significantly more macrophages than ears from young adult animals. Aged zebrafish also had fewer lateral line hair cells and less cell proliferation than young animals, although lateral line hair cells still robustly regenerated following damage. Unlike zebrafish, African turquoise killifish (an emerging aging model) only showed hair cell loss in the saccule of aged males, but both sexes exhibit age-related changes in the lateral line. Our work demonstrates that zebrafish exhibit key features of auditory aging, including hair cell loss and increased inflammation. Further, our finding that aged zebrafish have fewer lateral line hair cells yet retain regenerative capacity, suggests a decoupling of homeostatic hair cell addition from regeneration following acute trauma. Finally, zebrafish and killifish show species-specific strategies for lateral line homeostasis that may inform further comparative research on aging in mechanosensory systems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-related changes in the zebrafish and killifish inner ear and lateral line

Coffin,

Dale,

Molano

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In this case, we solve the modal analysis in the first 50 modes, and then a pressure of 1 Pa is applied to obtain the nominal unitary response in the tip of the tripus where the gas bladder contacts the ossicular chain, and a sweeping of values is done between 10 and 10 000 Hz. This sweeping range well contains the known hearing bandwidth of zebrafish [8][9][10]12,13,38]. We obtained the results of maximum displacement (μm) and velocity (μm s −1 ) in 200 points evenly distributed in that range.…”

Section: Modal and Harmonic Analysismentioning

confidence: 99%

“…Extensive research on the hearing system of zebrafish has contributed significantly to the fields of auditory genetics [1], epigenetics [2], synaptopathy [3], hair cell regeneration [4], ototoxicity [5] and beyond. The hearing capability of zebrafish has been evaluated at early developmental stages [6,7], entire life span [8][9][10][11], ageing [12] and comparisons of laboratory fish lines [13] using behavioural and electrophysiological auditory methods, which serve as fundamental baselines for further exploring of hearing mechanisms. It is widely accepted and demonstrated that Weberian apparatus of zebrafish, like any other otophysan fishes, contribute to their high hearing sensitivities and large frequency range compared to nonotophysan fishes [9,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that the formation of Weberian apparatus significantly increases hearing sensitivity [ 9 , 38 ]. However, after Weberian apparatus formed and functioned, there is disagreement in terms of whether the hearing threshold changes along size/age [ 8 , 10 , 12 , 38 ]. On the other hand, there is no doubt that the Weberian apparatus undergoes growth in tandem with the overall body growth, displaying either isometric or allometric patterns.…”

Section: Introductionmentioning

confidence: 99%

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Finite element modelling of sound transmission in the Weberian apparatus of zebrafish ( Danio rerio )

Marcé-Nogué,

Liu

2024

J. R. Soc. Interface.

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Zebrafish, an essential vertebrate model, has greatly expanded our understanding of hearing. However, one area that remains unexplored is the biomechanics of the Weberian apparatus, crucial for sound conduction and perception. Using micro-computed tomography (μCT) bioimaging, we created three-dimensional finite element models of the zebrafish Weberian ossicles. These models ranged from the exact size to scaled isometric versions with constrained geometry (1 to 10 mm in ossicular chain length). Harmonic finite element analysis of all 11 models revealed that the resonance frequency of the zebrafish's Weberian ossicular chain is approximately 900 Hz, matching their optimal hearing range. Interestingly, resonance frequency negatively correlated with size, while the ratio of peak displacement and difference of resonance frequency between tripus and scaphium remained constant. This suggests the transmission efficiency of the ossicular chain and the homogeneity of resonance frequency at both ends of the chain are not size-dependent. We conclude that the Weberian apparatus's resonance frequency can explain zebrafish's best hearing frequency, and their biomechanical characteristics are not influenced by isometric ontogeny. As the first biomechanical modelling of atympanic ear and among the few non-human ear modelling, this study provides a methodological framework for further investigations into hearing mechanisms and the hearing evolution of vertebrates.

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Zebrafish as a Model in Bioacoustics: Investigating Sensory Responses to Noisy Environments

Vasconcelos

2023

The Effects of Noise on Aquatic Life

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Age-related loss of auditory sensitivity in the zebrafish (Danio rerio)

Cited by 7 publications

References 70 publications

Age-related changes in the zebrafish and killifish inner ear and lateral line

Age-related changes in the zebrafish and killifish inner ear and lateral line

Finite element modelling of sound transmission in the Weberian apparatus of zebrafish ( Danio rerio )

Zebrafish as a Model in Bioacoustics: Investigating Sensory Responses to Noisy Environments

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