Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls

Draxler, Agnes; Blaschke, Amelie; Binar, Jessica; Weber, Maria; Haslacher, Michael; Bartak, Viktoria; Bragagna, Laura; Mare, George; Maqboul, Lina; Klapp, Rebecca; Herzog, Theresa; Széll, Marton; Petrera, Agnese; Laky, Brenda; Wagner, Karl-Heinz; Thell, Rainer

doi:10.1016/j.redox.2023.102914

Cited by 2 publications

(1 citation statement)

References 78 publications

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“…Monitoring the levels of these cells in the bloodstream can yield valuable insights into the health status of patients who are admitted to the hospital. Elevated concentrations of neutrophils in the circulatory system can function as a reliable marker for increased oxidative stress, particularly in populations that are more vulnerable, such as critically ill patients afflicted with COVID-19 [ 22 , 23 ]. The severity of the disease is exacerbated by the excessive presence of reactive oxygen species, which contribute to lung tissue damage, thrombosis promotion, and impairment of red blood cell functionality [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients

Farah,

Khamisy-Farah,

Dziedzic

et al. 2024

Cardiol J.

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Section: Introductionmentioning

confidence: 99%

The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients

Farah,

Khamisy-Farah,

Dziedzic

et al. 2024

Cardiol J.

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Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients

Tsuge,

Ichihara,

Hasegawa

et al. 2024

IJMS

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This study investigated the correlation between oxidative stress and blood amino acids associated with nitric oxide metabolism in adult patients with coronavirus disease (COVID-19) pneumonia. Clinical data and serum samples were prospectively collected from 100 adult patients hospitalized for COVID-19 between July 2020 and August 2021. Patients with COVID-19 were categorized into three groups for analysis based on lung infiltrates, oxygen inhalation upon admission, and the initiation of oxygen therapy after admission. Blood data, oxidative stress-related biomarkers, and serum amino acid levels upon admission were compared in these groups. Patients with lung infiltrations requiring oxygen therapy upon admission or starting oxygen post-admission exhibited higher serum levels of hydroperoxides and lower levels of citrulline compared to the control group. No remarkable differences were observed in nitrite/nitrate, asymmetric dimethylarginine, and arginine levels. Serum citrulline levels correlated significantly with serum lactate dehydrogenase and C-reactive protein levels. A significant negative correlation was found between serum levels of citrulline and hydroperoxides. Levels of hydroperoxides decreased, and citrulline levels increased during the recovery period compared to admission. Patients with COVID-19 with extensive pneumonia or poor oxygenation showed increased oxidative stress and reduced citrulline levels in the blood compared to those with fewer pulmonary complications. These findings suggest that combined oxidative stress and abnormal citrulline metabolism may play a role in the pathogenesis of COVID-19 pneumonia.

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Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls

Cited by 2 publications

References 78 publications

The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients

The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients

Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients

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