Age-related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects

Mutlu-Türkoglu, Ü.; Ilhan, Ebru; Öztezcan, Serdar; Kuru, Alev; Aykaç‐Toker, Gülçin; Uysal, Müjdat

doi:10.1016/s0009-9120(03)00035-3

Cited by 122 publications

(70 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MDA is one of the most often used biomarkers of oxidative stress on lipids associated with aging. An age-related increase in the plasma concentration of MDA has been documented in several studies [28,33,35,36]. Miguel J et al, in their study on a group of healthy men and women ranging in age from 20 to 70 years, demonstrated an age-related increase in MDA levels only among the women [28].…”

Section: Discussionmentioning

confidence: 88%

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Çakır

Goktas²,

Mutlu

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

Objectives: The aim of the study was to measure advanced oxidation protein products (AOPPs) as markers for oxidative stress to evaluate cardiovascular risk in pre-and postmenopausal women and to compare the results with malondialdehyde (MDA) levels. Material and methods:Twenty premenopausal women and 84 naturally postmenopausal patients were enrolled in the study. AOPP and MDA plasma levels were measured. The postmenopausal group was further subdivided into two groups: postmenopausal age of 40-49 and of 50-59 years. AOPP and MDA levels were compared between premenopausal, 40-49 and 50-59 year old menopausal women.Results: Plasma AOPP and MDA levels in postmenopausal women were increased when compared with their premenopausal peers (123.83 ± 55.51 µmol/L vs. 61.59 ± 16.42 µmol/L and 6.50 ± 1.05 µmol/L vs. 5.98 ± 0.77 µmol/L; respectively).

show abstract

Section: Discussionmentioning

confidence: 88%

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Çakır

Goktas²,

Mutlu

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…83,84 Levels of aldehydes, such as MDA-LDL and 4-hydroxy-2-nonenal (4-HNE), have been proposed as a biological signature of clinical in vivo LDL oxidation. [85][86][87][88][89] Mutlu-Turkoglu et al 87 reported that plasma MDA levels were increased in elderly subjects compared with those in young subjects. Lovell et al 89 have shown that ventricular fluid levels of 4-HNE are significantly higher in patients with Alzheimer's disease, an agerelated disease, than in control subjects.…”

Section: Tetrahydrobiopterin (Bh 4 )mentioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

View full text Add to dashboard Cite

Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

show abstract

“…The increased oxidative/nitrosative stresses found in aging animals and humans have been linked to peroxidative damage to lipids, DNA, proteins and carbohydrates as well increased levels of SOD and CAT, and impairment of the total antioxidant capacity (İnal et al 2001;Lasheras et al 2002;Mutlu-Türkoǧlu et al 2003;Rizvi and Maurya 2007;Dayhoff-Brannigan et al 2008;Alexandrova and Bochev 2009). In fact, excessive production of hydrogen peroxide is very harmful to aging muscles.…”

Section: Antioxidant Capacity and Healthy Aging: Does Exercise Matter?mentioning

confidence: 99%

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Ferrari

2011

Frontiers in Life Science

View full text Add to dashboard Cite

The objective of this article was to review the biochemical basis of the total antioxidant capacity (TAC) test and its applications to exercise science and promotion of healthy aging. Measurement of TAC allows evaluation of the antioxidant content of muscle, heart and other exercise-target organs. Acute non-regular physical exercise and body exposition to higher altitude have been associated with a considerable decrease of blood TAC. However, regular practice of physical activity and exercise is associated with improved antioxidant response increasing TAC levels. TAC methodologies did not address lipophylic antioxidants and have some other limitations. However, TAC is useful as a complementary test for the evaluation of antiperoxidation assays and blood, erythrocyte and cytosolic antioxidant enzyme assays (glutathion reductase, glutathion peroxidase, superoxide dismutase and catalase). Exercise induces both molecular antioxidant and hormetic responses which have been suggested to be linked with a healthy aging.

show abstract

Age-related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects

Cited by 122 publications

References 30 publications

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Endothelial dysfunction and hypertension in aging

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Contact Info

Product

Resources

About