Age-Related Increase in Blood Levels of Otolin-1 in Humans

Tabtabai, Ryan; Haynes, Laura; Kuchel, George A.; Parham, Kourosh

doi:10.1097/mao.0000000000001426

Cited by 27 publications

(26 citation statements)

References 31 publications

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“…As noted above, we have proposed the use of circulatory biomarkers toward better understanding of BPPV. We recently reported otolin-1 levels in healthy subjects as a function of age and noted a small but statistically significant age-related increase, consistent with degeneration of otoconia with age 18 . Now we hypothesize that if there is causal relationship between BPPV and low vitamin D levels, then there should be a relationship between otolin-1 and vitamin D levels in subjects without known vertigo.…”

Section: Introductionmentioning

confidence: 56%

“…This study was approved by the Institutional Review Board at UConn Health (#12-188-2; 15-006-3). Details of subject recruitment and otolin-1 levels for our subjects were reported elsewhere 18 . Briefly, after receiving informed consent, blood samples were obtained from 20 young (20–30 years old), 20 middle-aged (50–65 years old), and 20 old (66–80 years old) individuals, as well as 19 subjects in the oldest-old group (81–95 years old) using services of the UConn Center on Aging Recruitment and Community Outreach Research Cores (http://health.uconn.edu/aging/research/research-cores/).…”

Section: Methodsmentioning

confidence: 99%

“…All the samples were thawed at the same time. Otolin-1 measurements for these subjects have been previously described 18 . We measured 25-hydroxy vitamin D levels using an enzyme-linked immunosorbent assay (ELISA) kit (detection range 2.5 – 150 ng/mL, sensitivity 1 ng/mL) (MyBiosource.com, San Diego, Ca) as described in the manufacturer’s instruction manual.…”

Section: Methodsmentioning

confidence: 99%

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A Relationship Between Blood Levels of Otolin-1 and Vitamin D

Parham¹,

Kuchel²,

McElhaney

et al. 2018

Otology &Amp; Neurotology

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Our results demonstrate a relationship between vitamin D and otolin-1. The majority of our subjects had abnormally low vitamin D levels, but only those over 70 years of age showed a negative correlation with high otolin-1 levels. We postulate that a seasonal drop in vitamin D may not be sufficient for otoconia fragmentation and ultimately iBPPV, rather, chronically low vitamin D maybe required to induce otoconia degeneration.

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Section: Introductionmentioning

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Relationship Between Blood Levels of Otolin-1 and Vitamin D

Parham¹,

Kuchel²,

McElhaney

et al. 2018

Otology &Amp; Neurotology

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“…It serves as a scaffolding protein that connects otoliths and otoconial core matrix proteins to the inner ear sensory epithelial and acellular gel matrix. Recently, studies reported that otolin-1 can be detected in serum and that its levels significantly increase with age, consistent with the age-related degeneration of otoconia (18)(19)(20). A preliminary study found that only one-third of patients with BPPV had higher serum otolin-1 values than those found in healthy controls because some of the enrolled BPPV patients were not in the acute stage (21).…”

Section: Introductionmentioning

confidence: 70%

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Wu¹,

Wei²,

Lu³

et al. 2020

Front. Neurol.

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Objective: Otolin-1, a main specific otoconia matrix protein, passes through the labyrinth-blood barrier and is detectable in peripheral blood. Serum otolin-1 levels differ between patients with benign paroxysmal positional vertigo (BPPV) and healthy controls and are significantly age-related, increasing in healthy controls with age, suggesting that serum otolin-1 levels reflect otolith status. The aim of this study was to determine whether otolin-1 levels change during vertigo episodes in patients with BPPV and whether any change is specific and sensitive enough for BPPV episodes. Method: Patients diagnosed with de novo idiopathic BPPV during an acute episode were included in the study from May 2017 to May 2018. Blood samples were drawn before patients were treated with canalith-repositioning maneuvers. Serum otolin-1 levels were compared between 78 patients and 121 age-and sex-matched healthy individuals. Results: There were no significant differences between the groups in the age distribution, sex ratio, body mass index, clinical history, routine blood parameters, or total protein, albumin, uric acid, creatinine, blood urea nitrogen and lipid profiles (P > 0.05). Serum levels of otolin-1 were significantly higher in BPPV patients than in healthy controls (P < 0.001). Receiver operating characteristic analysis revealed that a serum otolin-1 value of 299.45 pg/ml was the optimal cutoff value to discriminate patients with BPPV from healthy controls (area under the curve 0.757, 95% CI 0.687∼0.826) with a sensitivity of 67.9% and a specificity of 72.7%. Conclusion: Serum levels of otolin-1 may be a potential biomarker for BPPV episodes.

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“…Second, we did not measure other markers for bone metabolism and probable markers for otoconia. Recent reports suggested that an inner ear collagen named otolin-1 could be a serological biomarker for otoconia degeneration ( 39 – 41 ). In further studies, the correlations between otolin-1 and bone metabolism markers were explored.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo

Fan

Jin

et al. 2018

Front. Neurol.

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Objective: Several studies have suggested a probable association between benign paroxysmal positional vertigo (BPPV) and both reduction of bone mineral density (BMD) and serum vitamin D levels, but none of these studies have explored their findings by examining bone turnover markers (BTM) in male idiopathic BPPV patients. This study aimed to evaluate the relationship between BMD and serum 25-hydroxyvitamin D (25(OH) D), with the occurrence of BPPV along with the characteristics of bone metabolism in male idiopathic BPPV patients.Methods: This retrospective study comprised 60 male idiopathic BPPV patients and 92 age-matched healthy controls referred to Ningbo No.2 Hospital during the period of February 2016 to February 2018. All subjects' serum levels of 25(OH) D, bone formation marker amino-terminal propeptide of type I procollagen (PINP), and bone resorption marker β-isomerized carboxy-terminal telopeptide of type I collagen (β-CTX) were measured. BMD was determined by dual energy X-ray absorption at the lumbar spine and hip.Results: Among male patients with BPPV, the prevalence of BMD reduction was 35.0%, which was similar to that of 27.2% in healthy controls. There were significant differences in the mean serum 25(OH) D level and prevalence of vitamin D deficiency between the two groups, with p-values of 0.049 and 0.009, respectively. The bone turnover markers of PINP and β-CTX in BPPV patients were lower than those in healthy controls. Logistic regression showed that vitamin D deficiency were associated with BPPV with an odds ratio of 3.8 (95% confidence interval = 1.25–11.73).Conclusion: Our study found that decreased serum vitamin D may be a risk factor for BPPV in male patients. The level of bone turnover among male patients with BPPV was lower than that among healthy controls.

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Age-Related Increase in Blood Levels of Otolin-1 in Humans

Cited by 27 publications

References 31 publications

A Relationship Between Blood Levels of Otolin-1 and Vitamin D

A Relationship Between Blood Levels of Otolin-1 and Vitamin D

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo

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