Age-Related Hearing Loss and Its Cellular and Molecular Bases

Ohlemiller, Kevin K.; Frisina, Robert D.

doi:10.1007/978-0-387-72561-1_6

Cited by 40 publications

(48 citation statements)

References 228 publications

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“…Age-related hearing loss is the major form of hearing loss and the single predominant neurodegenerative disease of aging (Schacht and Hawkins 2005;Ohlemiller and Frisina 2008;Frisina 2009;Schmiedt 2010). Assessments of human temporal bones have led to a general framework whereby three key inner ear components (hair cells, neurons, and strial cells) are taken to degenerate independently in a manner that reflects environmental and genetic risk factors that may be unique to each (Schuknecht 1974;Schuknecht and Gacek 1993).…”

Section: Introductionmentioning

confidence: 99%

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Ohlemiller

Dahl

Gagnon

2010

JARO

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Two inbred mouse strains, CBA/J and CBA/CaJ, have been used nearly interchangeably as 'good hearing' standards for research in hearing and deafness. We recently reported, however, that these two strains diverge after 1 year of age, such that CBA/CaJ mice show more rapid elevation of compound action potential (CAP) thresholds at high frequencies (Ohlemiller, Brain Res. 1277: 70-83, 2009). One contributor is progressive decline in endocochlear potential (EP) that appears only in CBA/CaJ. Here, we explore the cellular bases of threshold and EP disparities in old CBA/J and CBA/CaJ mice. Among the major findings, both strains exhibit a characteristic age (∼18 months in CBA/J and 24 months in CBA/CaJ) when females overtake males in sensitivity decline. Strain differences in progression of hearing loss are not due to greater hair cell loss in CBA/ CaJ, but instead appear to reflect greater neuronal loss, plus more pronounced changes in the lateral wall, leading to EP decline. While both male and female CBA/CaJ show these pathologies, they are more pronounced in females. A novel feature that differed sharply by strain was moderate loss of outer sulcus cells (or 'root' cells) in spiral ligament of the upper basal turn in old CBA/CaJ mice, giving rise to deep indentations and void spaces in the ligament. We conclude that CBA/CaJ mice differ both quantitatively and qualitatively from CBA/J in age-related cochlear pathology, and model different types of presbycusis.

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Section: Introductionmentioning

confidence: 99%

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Ohlemiller

Dahl

Gagnon

2010

JARO

Self Cite

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“…Auditory function in mammals is known to be significantly affected by aging, ultimately resulting in presbycusis (for review see Syka, 2002;Gates and Mills, 2005;Ohlemiller and Frisina, 2008). In the human population, a loss of speech understanding with aging constitutes an important health and social impairment Mazelova et al, 2003;Gordon-Salant et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in GAD levels in the central auditory system of the rat

Burianová

Ouda

Profant

et al. 2009

Experimental Gerontology

110

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“…Age-related cochlear change is wellcharacterized in the literature (e.g., Schuknecht and Gacek, 1993;reviews by Ohlemiller 2004reviews by Ohlemiller , 2006Ohlemiller and Frisina 2008) and predisposing factors such as gender, genetics, lifestyle, disease, and environmental causes have been identified. Age-related hearing loss (ARHL) is the most common cause of hearing impairment in humans, affecting 50% of the population by age 80.…”

Section: Introductionmentioning

confidence: 99%

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Mock

Jones

2010

JARO

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The CBA/CaJ mouse strain is commonly used as a control as it has no known genetic mutations affecting the inner ear, maintains hearing sensitivity throughout life, and serves as a background for creating new genetic strains. The purpose of the present study was to characterize the effects of age and gender on gravity receptor function and compare functional changes between auditory and vestibular modalities. Vestibular-evoked potentials (VsEPs), auditory brainstem responses (ABRs), and distortion product otoacoustic emissions were measured in 131 mice. VsEP thresholds deteriorated an average of 0.39 dB re: 1.0 g/ms per month and at the oldest ages (18-23 months old) showed an average loss of 49% of VsEP dynamic range. No significant gender differences were found for VsEPs. ABR thresholds increased by an average of 1.35, 1.38, and 1.15 dB pe SPL per month for ABR stimulus frequencies of 8, 16, and 32 kHz, respectively, demonstrating an average decrease in auditory dynamic range of 25-35% at advanced ages. Both modalities declined with age. Age-related decreases in gravity receptor sensitivity should be considered when using the CBA/CaJ strain for vestibular studies.

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Age-Related Hearing Loss and Its Cellular and Molecular Bases

Cited by 40 publications

References 228 publications

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Age-related changes in GAD levels in the central auditory system of the rat

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

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