Age-Related Hearing Loss and Its Association with Depression in Later Life

Brewster, Katharine K.; Ciarleglio, Adam; Brown, Patrick J.; Chen, Chen; Kim, Hae-Ok; Roose, Steven P.; Golub, Justin S.; Rutherford, Bret R.

doi:10.1016/j.jagp.2018.04.003

Cited by 90 publications

(91 citation statements)

References 36 publications

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“…Moreover, we found that chronic symptom trajectory class membership was associated with a higher increase in hearing difficulties and multimorbidity, probably because of reward loss on a daily basis (e.g., difficulty in holding conversations), regardless of sex (Brewster et al, 2018;Rote et al, 2015). On the other hand, subclinical trajectory class membership was distinguished by a higher increase in visual difficulties over time probably due to a moderate loss of reward (i.e., visual impairment limits independence) and sensory disability (Freeman et al, 2016;Tolman et al, 2005).…”

Section: Discussionmentioning

confidence: 76%

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Torre‐Luque

Prina

et al. 2019

Journal of Affective Disorders

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Published in: De la Torre-luque A, De la Fuente J, Prina M, Sanchez-Niubo A, Haro JM, Ayuso-Mateos JL. Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors. Abstract Background. This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthyageing outcomes later in life. Methods. The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Results. Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. Conclusion: This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription.

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Section: Discussionmentioning

confidence: 76%

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Torre‐Luque

Prina

et al. 2019

Journal of Affective Disorders

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“…ARHI is characterised by a non-syndromic bilateral, sensorineural hearing loss that progresses with increasing age and is an established risk factor for depression [6][7][8] and dementia [9][10][11][12] . Hearing loss was ranked fourth in the latest study into the Global Burden of Diseases 13 , yet hearing amplification devices are the only treatment option currently available for ARHI.…”

Section: Age-related Hearing Impairment (Arhi) Is the Most Common Senmentioning

confidence: 99%

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

Wells

Freidin

Abidin

et al. 2019

Preprint

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# Joint senior authors *Corresponding authors 2 Age-related hearing impairment (ARHI) is the most common sensory impairment in the aging population; a third of individuals are affected by disabling hearing loss by the age of 65 1 . ARHI is a multifactorial condition caused by both genetic and environmental factors, with estimates of heritability between 35% and 55% [2][3][4] . The genetic risk factors and underlying biological pathology of ARHI are largely unknown, meaning that targets for new therapies remain elusive.We performed genome-wide association studies (GWAS) for two self-reported hearing phenotypes, hearing difficulty (HDiff) and hearing aid use (HAid), using over 250,000 UK Biobank 5 volunteers aged between 40-69 years. We identified 44 independent genome-wide significant loci (P<5E-08), 33 of which have not previously been associated with any form of hearing loss. Gene sets from these loci are enriched in auditory processes such as synaptic activities, nervous system processes, inner ear morphology and cognition. Immunohistochemistry for protein localisation in adult mouse cochlea indicate metabolic, sensory and neuronal functions for NID2, CLRN2 and ARHGEF28 identified in the GWAS. These results provide new insight into the genetic landscape underlying susceptibility to ARHI.ARHI is characterised by a non-syndromic bilateral, sensorineural hearing loss that progresses with increasing age and is an established risk factor for depression 6-8 and dementia 9-12 . Hearing loss was ranked fourth in the latest study into the Global Burden of Diseases 13 , yet hearing amplification devices are the only treatment option currently available for ARHI. ARHI is expected to be a highly genetically heterogeneous trait given that over 150 genetic loci have been identified in non-syndromic hereditary hearing loss alone (https://hereditaryhearingloss.org/). Previous GWAS of ARHI have identified a small number of promising candidate genes, though there has been poor replication of findings to date, possibly reflecting varied phenotyping approaches and limited sample sizes 14-24 .We conducted two GWAS using the self-reported hearing difficulty and hearing aid use of UK Biobank (UKBB) participants and refined our results using a combination of conditional analysis, replication analysis, in silico annotation and in vivo expression analysis (see Figure 1 for study design). Our aim was to identify the genetic components of adult hearing impairment in the UK population and provide insight into the pathology of ARHI.3 UKBB participants were categorised using a case-control design based on responses to questions regarding hearing difficulty (HDiff, n=498,281) and hearing aid use (HAid, n=316,629) ( Supplementary Figure 1). A linear mixed-effects model was used to test for association between 9,740,198 SNPs and the two traits, using BOLT-LMM v.2 25 , which corrects for population stratification and within sample relatedness. Following additional quality control filters and selection of white British participants (described ...

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“…Considering the fact that GI subjects had tinnitus-associated hearing loss and the known relationship between hearing loss and age (14) , the results of the comparison between groups regarding age showed expected statistical differences, with higher mean in GI (*p<0.001). The prevalence of hearing loss, and consequently of tinnitus, is known to increase with age, regardless of exposure to occupational noise or lack thereof (15) .…”

Section: Discussionmentioning

confidence: 99%

Perfil clínico e implicações do zumbido em indivíduos com e sem perda auditiva

Bozza

Magni

et al. 2019

CoDAS

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RESUMO Objetivo comparar as características clínicas do zumbido e interferência na qualidade de vida em indivíduos com e sem perda auditiva associada, bem como discutir a associação de mensurações quantitativas e instrumentos qualitativos de avaliação. Método estudo quantitativo, descritivo e de corte transversal aprovado pelo Comitê de Ética em pesquisa (nº 973.314/2016 CAEE: 41634815.3.0000.0106). Foram comparadas as respostas da avaliação psicoacústica do zumbido (pesquisa de intensidade, frequência, nível mínimo de mascaramento e limiar de desconforto para tom puro e fala), bem como questionário Tinnitus Handicap Inventory (THI) e escala visual analógica (EVA) de 15 sujeitos portadores de zumbido e perda auditiva periférica (grupo GI) e 16 indivíduos normo-ouvintes (grupo GII). Resultados O escore médio na EVA e THI no GI foi, respectivamente, de 5,1(+1,5) e 42,3(+18) e no GII de 5,7(+2.6) e 32,7(+25), sugerindo incômodo moderado no GI e moderado/leve no GII (p>0,005). Verificou-se correlação moderada entre o THI e EVA apenas no GII. Na avaliação psicoacústica, observaram-se diferenças significantes entre os grupos referentes à medida da loudness (*p=0,013) e ao nível mínimo de mascaramento (*p=0,001). Conclusão a perda auditiva parece não se constituir em um fator determinante para o maior ou menor impacto do zumbido na qualidade de vida do sujeito. Já as diferenças encontradas entre os grupos, referentes às medidas psicoacústicas, podem ser justificadas pela presença do dano coclear em si. A mensuração objetiva do zumbido, independentemente da presença ou não da perda auditiva periférica, caracteriza-se como um importante instrumento complementar às medidas de auto avaliação.

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Age-Related Hearing Loss and Its Association with Depression in Later Life

Abstract: ARHL was associated with increased depressive symptoms in older adults. Future studies should investigate whether treatment of ARHL may be an effective prevention and/or therapeutic strategy for depressive symptoms.

Cited by 90 publications

References 36 publications

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

Perfil clínico e implicações do zumbido em indivíduos com e sem perda auditiva

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