Age-Related Hearing Loss and Cognitive Decline: You Haven't Heard the Half of It

Hewitt, Dale

doi:10.3389/fnagi.2017.00112

Cited by 23 publications

(16 citation statements)

References 20 publications

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“…Moreover, compared with normal hearing controls, PC patients with mild, moderate and severe hearing loss are, respectively, two, three and five times as likely to develop dementia ( Lin et al, 2011a ). In line with these findings, researchers have realized that PC may have a strikingly detrimental impact on cognitive function ( Mudar and Husain, 2016 ; Hewitt, 2017 ; Jayakody et al, 2018 ). Given that hearing loss is relatively easier to remediate than other risk factors for dementia and Alzheimer’s disease ( Mudar and Husain, 2016 ), it is highly important to illuminate the neural mechanisms that underlie PC-related cognitive decline.…”

Section: Introductionmentioning

confidence: 73%

Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study

Ren

et al. 2018

Front. Neurosci.

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Presbycusis (PC) is characterized by bilateral sensorineural hearing loss at high frequencies and speech-perception difficulties in noisy environments and has a strikingly detrimental impact on cognitive function. As the neural consequences of PC may involve the whole brain, we hypothesized that patients with PC would show structural alterations not only in the auditory cortex but also in the cortexes involved in cognitive function. The purpose of this study was to use surface-based morphometry (SBM) analysis to elucidate whole-brain structural differences between patients with PC and age-matched normal hearing controls. Three-dimensional T1-weighted MR images of 26 patients with mild PC and 26 age-, sex- and education-matched healthy controls (HCs) were acquired. All participants underwent a battery of neuropsychological tests. Our results revealed gray matter atrophy in several auditory cortical areas, nodes of the default mode network (DMN), including the bilateral precuneus and inferior parietal lobule, the right posterior cingulate cortex (PCC), and the right insula of patients with PC compared to that in the HCs. Our findings also revealed that hearing loss was associated with reduced gray matter volume in the right primary auditory cortex of patients with PC. Moreover, structural alterations in the nodes of the DMN were associated with cognitive impairments in PC patients. Additionally, this study provides evidence that a thicker right insula is associated with better speech perception in patients with PC. Based on these findings, we argue that the onset of PC seems to trigger its own cascade of conditions, including a need for increased cognitive resources during speech comprehension, which might lead to auditory and cognition-related cortical reorganization.

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Section: Introductionmentioning

confidence: 73%

Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study

Ren

et al. 2018

Front. Neurosci.

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“…In addition, there is growing evidence to show the importance of sensory functions and frailty status for cognitive outcomes. Numerous longitudinal studies have demonstrated associations of visual and hearing impairments with cognitive decline [16,17,18,19,20], although conflicting findings have also been reported in another study [21]. Frailty, a state of decline in function reserves [22], has been associated with cognitive decline and subsequently major neurodegenerative disorder (dementia) [23,24,25,26,27,28].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Assessment of Older People: Do Sensory Function and Frailty Matter?

Woo

2019

IJERPH

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Background: To examine the associations of visual and hearing functions, and frailty with subjective memory complaints (SMCs) in a community primary care pilot project of older people aged 60 years and over. Methods: The study was conducted in 24 community centers. A total of 1949 community-dwelling older people aged between 60–97 years were evaluated for which detailed information regarding socio-demographics, lifestyle, and clinical factors were documented at baseline and an average of 12 months later. SMCs were assessed using the 5-item Abbreviated Memory Inventory for the Chinese (AMIC). Visual and hearing functions were measured with two separate single questions. Frailty was assessed using a simple frailty question (FRAIL). Results: At baseline, 1685 (74.6%) participants had reported at least 3 SMCs (AMIC score ≥ 3). Of the 573 participants without / with 1–2 SMCs (AMIC score = 0–2) at baseline, 75 had incomplete data regarding SMCs and 190 developed at least 3 SMCs after 12 months. After adjustments for age, sex, marital status, educational level, hypertension, and diabetes at baseline, poor vision (OR 2.2 95% CI 1.8–2.7), poor hearing (OR 2.2 95% CI 1.8–2.8), and frailty (OR 4.6 95% CI 3.1–6.7) at baseline were each significantly associated with an increased risk of at least 3 SMCs at follow-up. After a further adjustment for baseline SMCs, the associations remained significant. Similar results were obtained when incident SMCs and improvement in subjective memory were used as the outcome variables; and Conclusions: In the care of older people, detection of sensory impairment and frailty through screening may allow formulation of strategies to prevent or delay the onset of cognitive decline.

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“…Cognition is evaluated with the MMSE in CI studies [36,47,48,62] and the Trail B by [49,73] in CI. The Digit-Symbol has been applied to HA users [43] but it has also been recommended for CI users [30]. The physical domain focuses on the tendency to fall and is addressed by the TUG applied to CI users [2,40].…”

Section: Discussionmentioning

confidence: 99%

Healthy aging in elderly cochlear implant recipients: a multinational observational study

et al. 2020

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Background: Given an increase in the aging population and its impact on healthcare systems, policy makers for provision of health and social services are aiming to keep older adults in good health for longer, in other words towards 'healthy aging'. Our study objective is to show that rehabilitation with cochlear implant treatment in the elderly with hearing impairment improves the overall health-related quality of life and general well-being that translate into healthy aging. Methods: The multicentre, prospective, repeated measures, single-subject, clinical observational study will accrue 100 elderly, first-time, unilateral CI recipients (≥ 60 years) and analyze changes on specific measurement tools over ca. 20 months from preimplant to postimplant. Evaluations will consist of details collected through case history and interview questionnaires by clinicians, data logging, self-report questionnaires completed by the recipients and a series of commonly used audiometric measures and geriatric assessment tools. The primary indicator of changes in overall quality of life will be the HUI-3. Discussion: The protocol is designed to make use of measurement tools that have already been applied to the hearing-impaired population in order to compare effects of CI rehabilitation in adults immediately before their implantation, (pre-implant) and after gaining 1-1.5 years of experience (post-implant). The broad approach will lead to a greater understanding of how useful hearing impacts the quality of life in elderly individuals, and thus improves potentials for healthy aging. Outcomes will be described and analyzed in detail. Trial registration: This research has been registered in ClinicalTrials.gov (http://www.clinicaltrials.gov/), 7 March 2017 under the n°NCT03072862.

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Age-Related Hearing Loss and Cognitive Decline: You Haven't Heard the Half of It

Cited by 23 publications

References 20 publications

Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study

Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study

Cognitive Assessment of Older People: Do Sensory Function and Frailty Matter?

Healthy aging in elderly cochlear implant recipients: a multinational observational study

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