Age-Related Hearing Loss

Vaisbuch, Yona; Maria, Peter L. Santa

doi:10.1016/j.otc.2018.03.002

Cited by 23 publications

(9 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that hearing loss affects 1 in every 3 persons > 65 years old, and every other person > 75 years old, in the United States. 46 However, in the present study, we have not found any difference in adjusted analyses for the age range between imbalance and SNHL in the elderly. This was observed both in those with HL and in those without HL.…”

Section: Discussioncontrasting

confidence: 79%

Posturographic Analysis in the Elderly with and without sensorineural Hearing Loss

Ciquinato

Doi

Silva

et al. 2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Sensorineural hearing loss (SNHL) is a serious public health problem. Some evidence suggests a significant relationship between SNHL and balance disorders. The inability to maintain balance associated with SNHL while standing further increases the risk of falls among older people. Objective To investigate the association between SNHL on the postural balance in elderly individuals of both genders. Methods The sample consisted of 247 (166 women) physically independent elderly individuals, (mean age = 68.4 ± 6.0). The instruments used were the anamnesis and the pure tone audiometry for hearing loss, and for balance a force platform based in measures of center of pressure area and of sway velocity in the anteroposterior and mediolateral directions. Results Presence of hearing loss (HL) was observed in 68% of the participants. We observed a significant association between SNHL and characteristics of balance between the groups with and without HL for center of pressure (COP) area (p = 0.010), anteroposterior velocity (p = 0.001) and mediolateral velocity (p = 0.020). There was a significant difference between the gender groups for center of pressure area (p = 0.004), anteroposterior velocity (p = 0.001) and mediolateral velocity (p = 0.001) with better performance in the female group. Amongst men, there was a difference between the ones with HL and those without it, for COP area (p = 0.049). Conclusion In the present study, elderly individuals with SNHL exhibited more instability on the postural balance, and elderly men presented worse results in the test.

show abstract

Section: Discussioncontrasting

confidence: 79%

Posturographic Analysis in the Elderly with and without sensorineural Hearing Loss

Ciquinato

Doi

Silva

et al. 2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…The hair cells within the organ of Corti are precisely arranged into one row of inner hair cells and three rows of outer hair cells, interdigitating with a variety of supporting cells; inner border, inner phalangeal, pillar cells, Deiters’ cells and Hensen’s cells ( Figure 1A ). Hair cells are susceptible to degeneration by a variety of genetic mutations and environmental stressors, such as exposure to loud noise, ototoxic drugs including cancer chemotherapy and aminoglycoside antibiotics, aging and over 200 known syndromic and non-syndromic genetic loci conferring predispositions to hearing loss ( Matsui et al, 2004 ; Cheng et al, 2005 ; Bodmer, 2008 ; Langer et al, 2013 ; Atkinson et al, 2015 ; Wong and Ryan, 2015 ; Vaisbuch and Santa Maria, 2018 ). In mammals hearing and balance are dependent on the maintenance of hair cells present at birth ( Groves, 2010 ; Géléoc and Holt, 2014 ), since hair cells do not spontaneously regenerate ( Roberson and Rubel, 1994 ; Chardin and Romand, 1995 ; Forge et al, 1998 ), and so their death leads to lifelong hearing loss and balance disorders.…”

Section: Introductionmentioning

confidence: 99%

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

Menendez

Trecek

Gopalakrishnan

et al. 2020

eLife

View full text Add to dashboard Cite

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing.

show abstract

“…A cochlear implant is another intervention option in cases when no benefit can be obtained from hearing aids due to an increase in the severity of the hearing loss. When communication abilities decrease due to hearing loss, interventions such as auditory rehabilitation (including interventions such as active listening training, speech reading, and communication enhancement) should also be used (4).…”

Section: Evaluation In Age-related Hearing Losses and Interventionmentioning

confidence: 99%

“…This rate increases every year depending on the prolongation of life duration. The ratio of the elderly population to the total population in the world will reach about 22% (1.2 million) by 2050, and more than 500 million elderly individuals will substantially be affected by age-related hearing loss (2,4). On the other hand, our country is estimated to have 20.8% elderly in 2050 (5).…”

Section: Introductionmentioning

confidence: 99%