2019
DOI: 10.1016/j.celrep.2019.08.043
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Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues

Abstract: Graphical Abstract Highlights d A multi-tissue age-related gene expression signature (AGES) is constructed d Linear, early, middle-, and late-life expression changes are discovered d AGES points to potential mechanisms inducing age-related disorders d Gene changes in multiple tissues include upregulation of interferon signaling SUMMARY To understand the changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produce a multi-ti… Show more

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Cited by 129 publications
(123 citation statements)
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“…We observe this signature even at 7 days in the OL, but it becomes stronger by 21 days. This is consistent with other studies that report that signatures of ageing appear gradually over the course of an organism's lifespan and not abruptly at later chronological ages [90][91][92] . We do not know whether the increased DNA damage signature we observe in the OLs is because the OLs intrinsically sustain higher levels of DNA damage or whether other parts of the brain better equipped to resolve DNA lesions.…”
Section: Dna Damage Accumulates In the Ol With Agesupporting
confidence: 93%
“…We observe this signature even at 7 days in the OL, but it becomes stronger by 21 days. This is consistent with other studies that report that signatures of ageing appear gradually over the course of an organism's lifespan and not abruptly at later chronological ages [90][91][92] . We do not know whether the increased DNA damage signature we observe in the OLs is because the OLs intrinsically sustain higher levels of DNA damage or whether other parts of the brain better equipped to resolve DNA lesions.…”
Section: Dna Damage Accumulates In the Ol With Agesupporting
confidence: 93%
“…The proportion of FR-PTC also increased with age in rat kidneys, increasing from ~5% at six months to ~12% at 27 months ( Fig. S5C) (16).…”
Section: Proximal Tubule Responses To Acute Injurymentioning
confidence: 83%
“…The proportion of FR-PTCs also increased with age in rat kidneys, increasing from ∼5% at 6 mo to ∼12% at 27 mo ( SI Appendix , Fig. S5 C ) ( 16 ).…”
Section: Resultsmentioning
confidence: 99%