Age-Related Eye Disease and Participation in Cognitive Activities

Varin, Mélanie; Kergoat, Marie‐Jeanne; Belleville, Sylvie; Li, Gisèle; Rousseau, Jacqueline; Roy-Gagnon, Marie-Hélène; Moghadaszadeh, Solmaz; Freeman, Ellen E.

doi:10.1038/s41598-017-18419-2

Cited by 20 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Having a longer interval between assessment of visual acuity and diagnosis of dementia and excluding those who developed dementia shortly after baseline might help minimize the possibility of reverse causation. Third, people with poor vision might experience more difficulties in accessing services for their health problems and in participating in physical, intellectual, and social activities ( 22 ). Whether poor visual acuity increases the risk of dementia independent of these health conditions and behaviors, which themselves have already been shown to be associated with dementia, requires further investigation.…”

mentioning

confidence: 99%

Higher Dementia Incidence in Older Adults with Poor Visual Acuity

Lee

Richards

Chan

et al. 2020

The Journals of Gerontology: Series A

View full text Add to dashboard Cite

Background Longitudinal evidence of poor visual acuity associating with higher risk of incident dementia is mixed. This study aimed to examine if poor visual acuity was associated with higher dementia incidence in a large community cohort of older adults, independent of the possible biases relating to misclassification error, reverse causality, and confounding effects due to health problems and behaviors. Methods A total of 15,576 community-living older adults without dementia at baseline were followed for 6 years to the outcome of incident dementia, which was diagnosed according to the ICD-10 or a Clinical Dementia Rating of 1 to 3. Visual acuity was assessed using the Snellen’s chart at baseline and follow-up. Important variables including demographics (age, sex, education, and socioeconomic status), physical and psychiatric comorbidities (cardiovascular risks, ophthalmological conditions, hearing impairment, poor mobility, and depression), and lifestyle behaviors (smoking, diet, physical, intellectual, and social activities) were also assessed. Results Over 68,904 person-years of follow-up, 1,349 participants developed dementia. Poorer visual acuity at baseline was associated with higher dementia incidence in 6 years, even after adjusting for demographics, health problems, and lifestyle behaviors, and excluding those who developed dementia within 3 years after baseline. Compared with normal vision, the hazard ratio of dementia was 1.19 (p = .31), 2.09 (p < .001), and 8.66 (p < .001) for mild, moderate, and severe visual impairment, respectively. Conclusions Moderate-to-severe visual impairment could be a potential predictor and possibly a risk factor for dementia. From a clinical perspective, older adults with poor visual acuity might warrant further risk assessment for dementia.

show abstract

mentioning

confidence: 99%

Higher Dementia Incidence in Older Adults with Poor Visual Acuity

Lee

Richards

Chan

et al. 2020

The Journals of Gerontology: Series A

View full text Add to dashboard Cite

show abstract

“…Performing fewer activities in older age can increase the risk of Alzheimer's disease or cognitive impairment, 17,18 and the loss of vision late in life may lead to a less active lifestyle. 19 Besides activity level, other potential intervening variables, also called mediators, could include life space and depressive symptoms. Life space, a measure of the spatial extent of a person over the previous month, 20 has been found to be associated with both eye disease 21 and cognitive function, 22 as have depressive symptoms.…”

mentioning

confidence: 99%

Age-Related Eye Disease and Cognitive Function

et al. 2020

Self Cite

View full text Add to dashboard Cite

Purpose: Age-related eye disease may be associated with cognitive decline, but the scientific literature has not been consistent. Furthermore, no studies have been able to explain the relationship. Our objective was to assess whether older adults with age-related macular degeneration (AMD) or glaucoma performed worse on 6 cognitive tests compared with older adults with normal vision and, if so, to understand why.Design: Cross-sectional analysis of hospital-based study (Maisonneuve-

show abstract

“…43,44 We previously reported that people with moderate and severe glaucoma performed fewer activities like reading, playing games, exercising, and socializing than people with normal vision. 45 Previous studies have shown glaucoma to be related to worse scores on the verbal digit forward and backward tests and the logical memory test, 17 the MMSE-Blind, 16 and with increased Alzheimer's disease. 46 Other studies have not shown associations between glaucoma and Alzheimer's disease.…”

Section: Discussionmentioning

confidence: 98%

Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging

Grant

Aubin

Buhrmann

et al. 2021

Ophthalmic Epidemiology

Self Cite

View full text Add to dashboard Cite

Purpose: To examine the longitudinal association between vision-related variables and the 3-year change in cognitive test scores in a community-dwelling sample of adults and to explore whether sex, education, or hearing loss act as effect modifiers. Methods: Data came from two waves of a 3-year population-based prospective cohort study (Canadian Longitudinal Study on Aging), which consisted of 30,097 randomly selected people aged 45-85 years from 7 Canadian provinces. Visual impairment (VI) was defined as binocular presenting visual acuity worse than 20/40. Participants were asked if they had ever had a diagnosis of age-related macular degeneration (AMD), glaucoma, or cataract. Cognitive change over 3 years was examined by calculating the difference between baseline and follow-up scores for the Rey Auditory Verbal Learning Test (RAVLT) and the RAVLT delayed test (memory tests), the Controlled Oral Word Association Test (COWAT) and the Animal Naming Test (ANT) (verbal fluency tests), and the Mental Alternation Test (MAT) (processing speed test). Multiple linear regression was used. Results: VI, AMD, and cataract were not associated with 3-year changes on any of the 5 cognitive tests after adjusting for age, sex, ethnicity, education, income, smoking, diabetes, stroke, heart disease, and province. A report of glaucoma was associated with greater declines in MAT scores (β = -0.60, 95% CI -1.03, -0.18). No effect modification was detected. Conclusions: Glaucoma was associated with worsening processing speed. Further research to confirm this finding and to understand the possible reason is necessary.

show abstract

Age-Related Eye Disease and Participation in Cognitive Activities

Cited by 20 publications

References 33 publications

Higher Dementia Incidence in Older Adults with Poor Visual Acuity

Higher Dementia Incidence in Older Adults with Poor Visual Acuity

Age-Related Eye Disease and Cognitive Function

Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging

Contact Info

Product

Resources

About