Age‐Related Endocrine Dysfunction in Nonhuman Primates

Goncharova, N. D.; Лапин, Б. А.

doi:10.1196/annals.1297.054

Cited by 30 publications

(20 citation statements)

References 7 publications

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“…However, our ACTH data argue against reduced negative feedback as the mediator of the extended prepubertal stress response. That is, ACTH levels were similar in prepubertal and adult females at all post-stress time points measured; thus, peripheral mechanisms may be responsible for the prolonged stress response prepubertally, as implicated in the extended stress response exhibited by aged nonhuman primates [23]. Future experiments will have to address whether the prepubertal adrenal cortex is more sensitive to ACTH than an adult’s, or if the adrenal cortex synthesizes more corticosterone prior to puberty in response to a stressor.…”

Section: Discussionmentioning

confidence: 99%

Differential Stress Reactivity in Intact and Ovariectomized Prepubertal and Adult Female Rats

2004

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The pubertal development of the hypothalamic-pituitary-adrenal (HPA) axis has received relatively little experimental attention. As puberty is marked by an increase in the susceptibility to various psychiatric disorders that may be related to HPA dysfunction, it is imperative to elucidate the pubertal development of this neuroendocrine axis. To date, the limited research in this area has been conducted primarily on males. Presently, we investigated stress responsiveness, as measured by both stress hormones (e.g., corticotropin (ACTH) and corticosterone) and gonadal steroids, in intact and ovariectomized prepubertal and adult female rats before and after a 30-min session of restraint stress. We report here that intact prepubertal females exhibit an extended corticosterone stress response (30–45 min longer) compared to intact adults. Moreover, ovariectomized prepubertal females continue to exhibit a prolonged stress-induced corticosterone and progesterone response compared to ovariectomized adults, indicating these protracted responses prior to puberty are independent of ovarian hormones. ACTH levels were not significantly different between intact and ovariectomized prepubertal and adult animals at all the post-stress time points measured, suggesting that the prolonged corticosterone response in prepubertal females is due to an enhanced sensitivity to ACTH at the level of the adrenal cortex. Taken together, these data indicate that stress reactivity changes dramatically during puberty in females. Furthermore, these data demonstrate additional development of the HPA axis during pubertal maturation, resulting in a more quickly terminated stress response in adulthood.

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Section: Discussionmentioning

confidence: 99%

Differential Stress Reactivity in Intact and Ovariectomized Prepubertal and Adult Female Rats

2004

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“…D'une façon générale, et dans les deux sexes, les rythmes journaliers des hormones sexuelles présents chez l'adulte s'affaiblissent ou disparaissent au cours du grand âge [2,15,[17][18][19][20]. Pour le microcèbe, primate à reproduction saisonnière, les variations saisonnières de testostérone plasmatique persistent avec une grande amplitude jusqu'à un âge très avancé (6-7 ans) puis disparaissent.…”

Section: Vieillissement Et Paramètres Endocriniensunclassified

“…Parmi les hormones surrénaliennes, les variations journalières du cortisol ne semblent pas affectées par l'âge et la tendance à une avance de phase du pic matinal, pas toujours observée, serait dépendante des saisons [2,20,22,23]. En revanche, la synthèse et production de déhydro-épiandrostérone (DHEA) et du sulfate de DHEA, phénomène apparemment spécifique aux primates, diminue au cours de l'âge chez l'homme dans les deux sexes et chez certains primates dont le microcèbe [19,20,24].…”

Section: Axe Hypothalamo-hypo-surrénalienunclassified

“…En revanche, la synthèse et production de déhydro-épiandrostérone (DHEA) et du sulfate de DHEA, phénomène apparemment spécifique aux primates, diminue au cours de l'âge chez l'homme dans les deux sexes et chez certains primates dont le microcèbe [19,20,24]. Considérés comme un marqueur du vieillissement biologique, les taux de DHEA seraient même indicateurs de la longévité intra-et interspécifi-que.…”

Section: Axe Hypothalamo-hypo-surrénalienunclassified

“…Le premier niveau concerne la réception de la lumière et s'il existe une opacification progressive du cristallin chez les primates âgés, son effet sur l'entraînement des rythmes reste à définir. En revanche, la sécrétion de mélatonine, qui reflète la transduction de la lumière, diminue avec souvent un décalage du pic nocturne chez les primates testés et l'homme [5,20,25]. Chez le microcèbe, les profils de mélatonine s'altèrent égale-ment avec le vieillissement et les différences saisonnières, normalement observées chez l'adulte jeune, s'estompent [26] (Figure 5A).…”

Section: Effet Du Vieillissement Sur Les Mécanismes Centrauxunclassified

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Vieillissement et rythmes biologiques chez les primates

Perret

Aujard

2006

Med Sci (Paris)

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Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

Lopez,

Seidl,

Phillips

2024

American J Primatol

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Human aging is associated with senescence of the hypothalamic–pituitary–adrenal (HPA) axis, leading to progressive dysregulation characterized by increased cortisol exposure. This key hormone is implicated in the pathogenesis of many age‐related diseases. Common marmosets (Callithrix jacchus) display a wide spectrum of naturally occurring age‐related pathologies that compare similarly to humans and are increasingly used as translational models of aging and age‐related disease. Whether the marmoset HPA axis also shows senescence with increasing age is unknown. We analyzed hair cortisol concentration (HCC) across the lifespan of 50 captive common marmosets, ranging in age from approximately 2 months–14.5 years, via a cross‐sectional design. Samples were processed and analyzed for cortisol using enzyme immunoassay. HCC ranged from 1416 to 15,343 pg/mg and was negatively correlated with age. We found significant main effects of age group (infant, adolescent, adult, aged, very aged) and sex on HCC, and no interaction effects. Infants had significantly higher levels of HCC compared with all other age groups. Females had higher HCC than males. There was no interaction between age and sex. These results suggest marmosets do not show dysregulation of the HPA axis with increasing age, as measured via HCC.

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Age‐Related Endocrine Dysfunction in Nonhuman Primates

Cited by 30 publications

References 7 publications

Differential Stress Reactivity in Intact and Ovariectomized Prepubertal and Adult Female Rats

Differential Stress Reactivity in Intact and Ovariectomized Prepubertal and Adult Female Rats

Vieillissement et rythmes biologiques chez les primates

Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

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