Age‐Related Effects on the Biological Clock and its Behavioral Output in a Primate

Aujard, Fabienne; Cayetanot, Florence; Bentivoglio, Marina; Perret, Martine

doi:10.1080/07420520500482090

Cited by 64 publications

(66 citation statements)

References 35 publications

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“…Age-related disruptions in sleep in humans and locomotor activity in non-human primates have been well documented (Wu and Swaab 2007;Aujard et al 2006). Recent data suggest that these disruptions are due to weaker circadian regulation of sleep and wakefulness rather than alterations in the homeostatic mechanisms governing the sleep/wake cycle (Cajochen et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Circadian clock resetting in the mouse changes with age

Biello

2009

AGE

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The most widely recognised consequence of normal age-related changes in biological timing is the sleep disruption that appears in old age and diminishes the quality of life. These sleep disorders are part of the normal ageing process and consist primarily of increased amounts of wakefulness and reduced amounts of deep sleep. Changes in the amplitude and timing of the sleep-wake cycle appear to represent, at least in part, a loss of effective circadian regulation of sleep. Understanding alterations in the characteristics of stimuli that help to consolidate internal rhythms will lead to recommendations to improve synchronisation in old age. Converging evidence from both human and animal studies indicate that senescence is associated with alterations in the neural structure thought to be primarily responsible for the generation of the circadian oscillation, the suprachiasmatic nuclei (SCN). Work has shown that there are changes in the anatomy, physiology and ability of the clock to reset in response to stimuli with age. Therefore it is possible that at least some of the observed age-related changes in sleep and circadian timing could be mediated at the level of the SCN. The SCN contain a circadian clock whose activity can be recorded in vitro for several days. We have tested the response of the circadian clock to a number of neurochemicals that reset the clock in a manner similar to light, including glutamate, N-methyl-D-aspartate (NMDA), gastrin-releasing peptide (GRP) and histamine (HA). In addition, we have also tested agents which phase shift in a pattern similar to behavioural 'non-photic' signals, including neuropeptide Y (NPY), serotonin (5HT) and gamma-aminobutyric acid (GABA). These were tested on the circadian clock in young and older mice (approximately 4 and 15 months old). We found deficits in the response to specific neurochemicals but not to others in our older mice. These results indicate that some changes seen in the responsiveness of the circadian clock to light with age may be mediated at the level of the SCN. Further, the responsiveness of the circadian clock with age is attenuated to some, but not all stimuli. This suggests that not all clock stimuli loose their effectiveness with age, and that it may be possible to compensate for deficits in clock performance by enhancing the strength of those stimulus pathways which are intact.

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Section: Discussionmentioning

confidence: 99%

Circadian clock resetting in the mouse changes with age

Biello

2009

AGE

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“…Peaks in arginine vasopressin and vasoactive intestinal peptide were shifted. Changes in rhythms of these hormones could impair SCN signaling [332]. Spontaneous motor activity during the scotophase declined in aged rats and the activity pattern suggested loss of circadian amplitude.…”

Section: The Aging Clockmentioning

confidence: 99%

Dopamine and Aging: Intersecting Facets

Rollo

2008

Neurochem Res

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Aging encompasses life itself so understanding requires frameworks that forge unity amidst complexity. The free radical theory of aging is one example. The original focus on damage was augmented recently by appreciation that reactive oxygen and nitrogen species are essential to normal signaling and cell function. This paradigm is currently undergoing an explosive expansion fueled by the discovery that regulatory organization is a merry-go-round of redox cycling seamlessly fused to endogenous clocks. This might best be described as an "Electroplasmic Cycle." This is certainly applicable to dopaminergic neurons with their exceptional metabolic, electrical and rhythmic properties. Here I review normal aging of dopamine systems to highlight them as a valuable model. I then examine the possible integration of free radical and ion channel theories of aging. Finally, I incorporate clocks and explore the multifaceted implications of electroplasmic cycles with special emphasis on dopamine.

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“…Gray mouse lemurs are small nocturnal primates originating from Madagascar with very marked circadian rhythms (Aujard et al, 2006). They exhibit daily hypothermia (torpor) (Génin and Perret, 2003) with high body temperature (Tb) during the active period that then falls to its minimum before the onset of the light phase (Terrien et al, 2010).…”

mentioning

confidence: 99%

Resveratrol Dietary Supplementation Shortens the Free-Running Circadian Period and Decreases Body Temperature in a Prosimian Primate

et al. 2011

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Resveratrol (RSV) is a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. We tested the effect of RSV on the circadian clock in a nonhuman primate, the gray mouse lemur. The impact of a 2-week dietary supplementation of RSV on the rhythms of locomotor activity and body temperature in constant dark conditions (DD) was investigated in young (n = 7) and old (n = 6) animals. RSV supplementation followed 2 weeks in DD under normal diet (CTL). In both young and old animals receiving RSV, we observed a shortening of the free-running period compared to those under CTL (-15 minutes in young animals and -45 minutes in old animals), accompanied by a lower mean body temperature in both age groups and decreased locomotor activity in young animals. Thus, RSV is a food component capable of influencing a primate's circadian clock. This property may be of interest clinically in the context of the treatment of circadian disruption and in the context of the effects of RSV ingestion on health.

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Age‐Related Effects on the Biological Clock and its Behavioral Output in a Primate

Cited by 64 publications

References 35 publications

Circadian clock resetting in the mouse changes with age

Circadian clock resetting in the mouse changes with age

Dopamine and Aging: Intersecting Facets

Resveratrol Dietary Supplementation Shortens the Free-Running Circadian Period and Decreases Body Temperature in a Prosimian Primate

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