Age related effects of pesticide exposure on neurobehavioral performance of adolescent farm workers in Brazil

Eckerman, David A.; Gimenes, Lincoln S.; Souza, Rosane Curi de; Galvão, Patricia Regina Lopes; Sarcinelli, Paula de Novaes; Chrisman, Juliana de Rezende

doi:10.1016/j.ntt.2006.09.028

Cited by 45 publications

(60 citation statements)

References 18 publications

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“…Increased performance deficits were associated with increased years working in agriculture in adult and adolescent farmworkers (Rohlman, et al, 2007b). Adolescent farm workers in Brazil showed performance deficits associated with an index of exposure (Eckerman, et al, 2006). A positive correlation between urinary organophosphate metabolite levels and poorer performance on neurobehavioral tests in adult agricultural workers has also been reported (Rothlein, et al, 2006).…”

Section: Discussionmentioning

confidence: 92%

“…Studies have demonstrated performance deficits associated with children working in agriculture. Adolescent farm workers in Brazil showed impairment on several neurobehavioral measures including attention, response speed and coordination, when compared to children living in an urban area and not working in agriculture (Eckerman, et al, 2006). Although the sample size was small, younger children (10-11 years old) showed more impairment than older children.…”

Section: Neurobehavioral Effects Of Pesticide Exposurementioning

confidence: 85%

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Adaptation of the Behavioral Assessment and Research System (BARS) for evaluating neurobehavioral performance in Filipino children

et al. 2008

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Neurobehavioral tests have long been used to assess health effects in exposed working adult populations. The heightened concern over the potential impact of environmental exposures on neurological functioning in children has led to the development of test batteries for use with children. There is a need for reliable, easy-to-administer batteries to assess neurotoxic exposure in children. One such test battery previously validated with Spanish-and English-speaking children ages 4 and older, combines computerized tests from the Behavioral Assessment and Research System (BARS) with non-computerized tests. The goal of the present study was to determine the feasibility of using standardized neurobehavioral tests in preschool and school-aged Filipino children. Test instructions were translated into the vernacular, Tagalog or Tagalog-English ("Taglish") and some instructions and materials were modified to be appropriate for the target populations. The battery was administered to 4 to 6 year old Filipino children (N=50). The performance of the Filipino children was compared to data previously collected from Spanish-and English-speaking children tested in the US. The majority of children had no difficulty completing the tests in the battery with the exception of the Symbol-Digit test and Digit Span-reverse. The three groups showed similar patterns of performance on the tests and the older children performed better than the younger children on all of the tests. The findings from this study demonstrate the utility of using this test battery to assess cognitive and motor performance in Filipino children. Tests in the battery assess a range of functions and the measures are sensitive to age differences. The current battery has been utilized in several cultures and socio-economic status classes, with only minor modifications needed. This study demonstrates the importance of pilot testing the methods before use in a new population, to ensure that the test is valid for that culture.

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Section: Discussionmentioning

confidence: 92%

Section: Neurobehavioral Effects Of Pesticide Exposurementioning

confidence: 85%

Adaptation of the Behavioral Assessment and Research System (BARS) for evaluating neurobehavioral performance in Filipino children

et al. 2008

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“…The battery was assembled by combining computerized tests from the Behavioral Assessment and Research System (BARS), performance tests adapted from the Pediatric Environmental Test Battery (PENTB), and a test of recall and recognition (Rohlman, et al, 2000;Rohlman, et al, 2001b). The current battery has been validated in several cultures and socio-economic status classes, with only minor modifications needed (Chiodo, et al, 2006;Eckerman, et al, 2006;Rohlman, et al, in press). Performance tests from the BARS have been used in several studies examining pesticide exposure in children and adolescents (Eckerman, et al, 2006;Rohlman, et al, 2001a;Rohlman, et al, 2007c;Rohlman, et al, 2005).…”

Section: Assessment Of Neurobehavioral Effects In Vulnerable Populatimentioning

confidence: 99%

“…The current battery has been validated in several cultures and socio-economic status classes, with only minor modifications needed (Chiodo, et al, 2006;Eckerman, et al, 2006;Rohlman, et al, in press). Performance tests from the BARS have been used in several studies examining pesticide exposure in children and adolescents (Eckerman, et al, 2006;Rohlman, et al, 2001a;Rohlman, et al, 2007c;Rohlman, et al, 2005). During adolescence, children often are working in agriculture and are occupationally exposed to pesticides.…”

Section: Assessment Of Neurobehavioral Effects In Vulnerable Populatimentioning

confidence: 99%

Neurobehavioral testing in human risk assessment

et al. 2008

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Neurobehavioral tests are being increasingly used in human risk assessment and there is a strong need for guidance. The field of neurobehavioral toxicology has evolved from research which initially focused on using traditional neuropsychological tests to identify "abnormal cases" to include methods used to detect sub-clinical deficits, to further incorporate the use of neurosensory assessment, and to expand testing from occupational populations to vulnerable populations including older adults and children. Even as exposures in the workplace are reduced, they have been increasing in the environment and research on exposure has now expanded to cross the entire lifetime. These neurobehavioral methods are applied in research and the findings used for regulatory purposes to develop preventative action for exposed populations. This paper reflects a summary of the talks presented at the symposium presented at the 11th meeting of the International Neurotoxicology Association.

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“…Este fato leva à preocupação quanto ao seu impacto nas populações e na qualidade ambiental (ARAÚJO et al, 2007;ECKERMAN et al, 2007). Os riscos devido às perturbações ambientais são de difícil predição devido à complexidade das interações e variabilidade dos ecossistemas e seus organismos, sendo necessária a compreensão da interação entre os insumos agrícolas como os agrotóxicos e os ecossistemas para assegurar o uso sustentável destes compostos no ambiente.…”

Section: Introductionunclassified

Proposta conceitual de estudo para a integração e gerenciamento do uso de marcadores bioquímicos de contaminação ambiental

Castro

Jonsson

2011

Biotemas

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A agricultura sustentável prioriza o uso racional da terra e da biota. Para tanto, é necessária a compreensão da interação entre os insumos agrícolas e os ecossistemas. Porém, há carência de métodos de fácil acesso para a verificação de contaminação ambiental por muitos desses produtos, como os agrotóxicos e de suas misturas. A aplicação de métodos alternativos no monitoramento de áreas degradadas pode gerar vantagens econômicas quando comparados à implementação de protocolos de análise que utilizam métodos de alto custo que demandam maior tempo de análise. Uma vez que a saúde ambiental pode ser avaliada por meio de estudos com indicadores biológicos, a abordagem aqui apresentada objetiva discutir alguns aspectos a respeito do monitoramento de risco ambiental com organismos não-alvo sentinela, focando parâmetros bioquímicos. Tais parâmetros evidenciariam que o agrotóxico penetrou no organismo e ocasionou uma resposta a um efeito de acordo com a dose ou o tempo de exposição. Esses parâmetros poderão ser utilizados como indicadores biológicos bioquímicos em programas de monitoramento ambiental devido à identificação precoce de alterações. Os resultados obtidos de seu uso poderão ser utilizados para subsidiar políticas relacionadas ao gerenciamento de riscos ambientais. Palavras-chave: Agrotóxicos, Árvore de decisão, Enzimas, Indicadores biológicos, Monitoramento ambiental AbstractConceptual study proposal for the integration and management of biochemical markers of environmental contamination use. Sustainable agriculture prioritizes the rational use of land and biota. For this, there is a need for understanding the interaction between the agriculture inputs and the ecosystems. However, there is a lack of easy access methods for verifying environmental contamination due to many of these products, such as pesticides and their mixtures. The application of alternative methods for monitoring degraded areas can generate economic advantages when compared to the implementation of protocols for analysis using high cost methods which demand a longer analysis time. Since environmental health can be accessed through studies using biomarkers, the approach presented here aims to discuss some aspects on the environmental risk monitoring with sentinel non-target organisms, focusing on biochemical parameters. Such parameters showed that the pesticide penetrated into the body and caused a response according to the dose or time of exposition.

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Age related effects of pesticide exposure on neurobehavioral performance of adolescent farm workers in Brazil

Cited by 45 publications

References 18 publications

Adaptation of the Behavioral Assessment and Research System (BARS) for evaluating neurobehavioral performance in Filipino children

Adaptation of the Behavioral Assessment and Research System (BARS) for evaluating neurobehavioral performance in Filipino children

Neurobehavioral testing in human risk assessment

Proposta conceitual de estudo para a integração e gerenciamento do uso de marcadores bioquímicos de contaminação ambiental

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