Age-related effects in T cell activation and proliferation

Song, Lijun; Kim, Young Ho; Chopra, Rajesh; Proust, Jacques; Nagel, James; Nordin, Albert A.; Adler, William H.

doi:10.1016/0531-5565(93)90058-l

Cited by 114 publications

(56 citation statements)

References 27 publications

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“…First, it is possible that the intrinsic ability of cells to undergo apoptosis declines with age, due to changing patterns in chromatin or in other determinants of gene expression (Issa et al, 1994). Second, it is possible that the decreased apoptosis reflects an age-specific difference in lymphocyte subtypes that populate the spleen (Song et al, 1993). It is known that radiation sensitivities vary with cell type, and it is possible that differences in lymphocytic subtypes could account for our results.…”

Section: Resultsmentioning

confidence: 43%

“…Many cellular functions, including DNA repair, regulation of cell proliferation, endocrine and immune responses decline with age (Hart and Turturro, 1992;Cohen, 1994;Song et al, 1993;Miller, 1996). Partly as a consequence of these changes, certain diseases such as cancer and immune system disorders occur more frequently in older individuals (Cohen, 1994;Nakamura et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Less death in the dying

Polyák

Hamilton

et al. 1997

Cell Death Differ

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Diseases associated with aging are now the primary causes of death in developed countries. This is in part due to the long recognized exponential association of cancer with age and perhaps to a deterioration of the immune system with advanced age. Both prevention of tumorigenesis and immune function are critically dependent on apoptosis. In this study we examined apoptosis in mice of various age following gamma irradiation. We found a striking agedependent decrease in radiation-induced apoptosis in splenic lymphocytes but not in colorectal epithelial cells. These observations may therefore provide a clue to the decline of immune function with age.

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Section: Resultsmentioning

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Less death in the dying

Polyák

Hamilton

et al. 1997

Cell Death Differ

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“…Aging is accompanied by changes in the immune system, including impairment of delayed type hypersensitivity and other T cell functions [13,14]. Although the mechanisms underlying these age-dependent defects in T cell functions are not completely elucidated, alterations in signal transduction may 0014-5793/95/$9.50 © 1995 Federation of European Biochemical Societies.…”

Section: Introductionmentioning

confidence: 99%

Cellular distribution of protein kinase C isozymes in CD3‐mediated stimulation of human T lymphocytes with aging

et al. 1995

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Protein kinase C (PKC) is involved in a variety of cellular responses, such as the expression and secretion of IL-2, the regulation of cytotoxic killing and cell proliferation. It is known that these immune functions are altered with aging. Here, we show that anti-CD3-triggered T cell proliferation is significantly decreased with aging and that H7, an inhibitor of PKC, impairs the anti-CD3-induced T cell proliferation in a differential manner, lymphocytes of healthy young subjects being more sensitive to the PKC inhibitor than those of elderly subjects. We examined (Western blot) the presence and the cellular distribution of PKC isozymes in T lymphocytes of healthy young and elderly subjects in the resting state and after anti-CD3 mAb stimulation using antibodies directed against PKC 6,/3, 8, e and isoforms in the cytosol and the plasma membrane fractions. These five PKC isotypes were present in human T cells of young and elderly subjects. However, their distribution between the cytosolic and membrane fractions varied according to the isozymes and the age of the subjects. In resting lymphocytes of young subjects, all the PKC isozymes were found in the cytosolic fraction, except PKC-~. In resting lymphocytes of elderly subjects PKC-~ and -e were almost equally distributed between the cytosolic and the membrane fractions, whereas PKC-, and -~ were mainly found in the membrane fraction and PKC-/3 was almost exclusively located in the cytosolic fraction. The translocation of PKC-c~, -/3, -~ and -E could be observed under anti-CD3 mAb stimulation in lymphocytes of young subjects, while in the case of elderly subjects only the PKC ]3 isoform was translocated. Our results suggest that the decreased availability of cytosolic PKC may contribute to the diminished PKC-dependent responses to CD3-triggered stimulation of human T lymphocytes with aging.

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“…In vitro studies on the effects of age on cell-mediated immunity have mainly focused on the response of T lymphocytes to mitogenic stimuli. The age-related decline of immunity is manifested mainly by impairment in the lymphoproliferative response (Solana et al, 1991;Song et al, 1993) and cytokine secretion (Rink et al, 1998) to mitogenic stimuli. Cytokines are a key component in the regulatory communication among immune cells; they are responsible for the differentiation, proliferation and survival of the lymphoid cells and play an important role in immune sensitized mice.…”

Section: Hemohim Recovers the Declined Nk Cell Activity In Aged Micementioning

confidence: 99%

Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

Park¹,

Jo²,

Jung³

et al. 2007

Phytotherapy Research

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The effect of a new herbal composition, HemoHIM, on immune functions was examined in aged mice, in which various immune responses had been impaired. The composition HemoHIM was prepared by adding the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix. Supplementation to the aged mice with HemoHIM restored the proliferative response and cytokine production of splenocytes with a response to ConA. Also, HemoHIM recovered the NK cell activity which had been impaired in the aged mice. Meanwhile aging is known to reduce the Th1-like function, but not the Th2-like function, resulting in a Th1/Th2 imbalance. HemoHIM restored the Th1/Th2 balance in the aged mice through enhanced IFN-γ γ γ γ γ and IgG2a production, and conversely a reduced IL-4 and IgG1 production. It was found that one factor for the Th1/Th2 imbalance in the aged mice was a lower production of IL-12p70. However, HemoHIM restored the IL-12p70 production in the aged mice. These results suggested that HemoHIM was effective for the restoration of impaired immune functions of the aged mice and therefore could be a good recommendation for immune restoration in elderly humans.

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Age-related effects in T cell activation and proliferation

Cited by 114 publications

References 27 publications

Less death in the dying

Less death in the dying

Cellular distribution of protein kinase C isozymes in CD3‐mediated stimulation of human T lymphocytes with aging

Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

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