Age related differences in plasma theophylline levels

Abstract

Because of its special pharmacokinetic properties, plasma levels of theophylline show significant differences between individuals and also its therapeutic index is very low. So, plasma theophylline concentration measurements are essential for an effective and safe treatment. In the present study, age related differences in plasma theophylline levels were evaluated in patients from different age groups. Patients were divided randomly into two groups. Group I included patients under the age of 50 years, group II included patients over 50 years of age. Plasma theophylline levels were measured before and 3, 7, 12 and 19 h after a single dose given orally. The results show that 3, 7 and 19 h post dose, levels of theophylline were significantly higher in group II than in group I (P < 0.001).