Age-related differences in network structure and dynamic synchrony of cognitive control

Hinault, Thomas; Mijalkov, Mite; Pereira, Joana B.; Volpe, Giovanni; Bakke, A.; Courtney, Susan

doi:10.1016/j.neuroimage.2021.118070

Cited by 16 publications

(31 citation statements)

References 67 publications

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“…In order to evaluate brain networks' characteristics over time, Hidden Markov Models represent brain activity as a succession of discrete states (i.e., characterized by matrices of specific couplings between brain regions), with each state in the finite set of states being dominant at certain time points and not at others (e.g., Tal et al, 2020). Graph theory analyses have also been conducted to examine changes with aging (e.g., Van Straaten & Stam, 2013;Hinault et al, 2021). Brain networks are described as an architecture composed of nodes (i.e., brain regions) and edges between each pair of nodes (i.e., functional or effective connectivity).…”

Section: Box 2 Methods For Characterizing Brain Dynamicsmentioning

confidence: 99%

“…On the other hand, a relative preservation of structural integrity led to larger synchrony and less interference. Data from Hinault et al, , 2021…”

Section: Figure 5 Eeg Alpha and Gamma Plv Synchrony Was Assessed During The Completion Of An Arithmetic Verification Task Including Intermentioning

confidence: 99%

“…Compensatory activations in older adults with preserved cognitive performance are observed and mainly consist in higher alpha synchrony between distant brain regions (e.g., Ariza et al, 2015). Moreover, changes of alpha network dynamics are also associated with the functional reorganization observed in fMRI (Balster et al, 2013) and the alteration of network structure assessed with white-matter microstructural integrity (Teipel et al, 2009;Hinault et al, , 2021.…”

Section: Healthy Agingmentioning

confidence: 99%

“…During healthy aging, differences between individuals showing little to no differences in taskrelated dynamics compared to young adults, relative to others showing slower dynamics and cognitive decline (e.g., Babiloni et al, 2004;Coquelet et al, 2017), could be used as a marker of brain maintenance. Brain maintenance is also expected to be associated with the preservation of phase synchrony between distant brain regions (e.g., López et al 2014a;Hinault et al, , 2021. Earlier activations observed in healthy older individuals Proskovec et al, 2016;Staub et al, 2014) would reflect mechanisms of cognitive reserve to maintain similar cognitive performance to younger individuals.…”

Section: Healthy Agingmentioning

confidence: 99%

“…Changes of dynamic connectivity would take place to maintain cognitive performance (e.g., Ariza et al, 2015), while failure to do so would result in cognitive decline. Cognitive reserve is also associated with brain reserve through individual integrity levels of underlying white matter tracts (Hinault et al, , 2021.…”

Section: Healthy Agingmentioning

confidence: 99%

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When the time is right: Temporal dynamics of brain activity in healthy aging and dementia

Courtney

Hinault

2021

Progress in Neurobiology

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Section: Box 2 Methods For Characterizing Brain Dynamicsmentioning

confidence: 99%

“…On the other hand, a relative preservation of structural integrity led to larger synchrony and less interference. Data from Hinault et al, , 2021…”

Section: Figure 5 Eeg Alpha and Gamma Plv Synchrony Was Assessed During The Completion Of An Arithmetic Verification Task Including Intermentioning

confidence: 99%

Section: Healthy Agingmentioning

confidence: 99%

Section: Healthy Agingmentioning

confidence: 99%

Section: Healthy Agingmentioning

confidence: 99%

See 3 more Smart Citations

When the time is right: Temporal dynamics of brain activity in healthy aging and dementia

Courtney

Hinault

2021

Progress in Neurobiology

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White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans

Park,

Yoon,

Park

et al. 2024

GeroScience

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Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer’s disease in mouse models. However, clinical trials in Alzheimer’s disease (AD) patients have yielded inconsistent results, necessitating further investigation. This single-center pre-post intervention study aims to explore the influence of white matter microstructural integrity on gamma rhythm propagation from the visual cortex to AD-affected regions in 31 cognitively normal volunteers aged ≥ 65. Gamma rhythm propagation induced by optimal FLS was measured. Diffusion tensor imaging was employed to assess the integrity of white matter tracts of interest. After excluding 5 participants with a deficit in steady-state visually evoked potentials, 26 participants were included in the final analysis. In the linear regression analyses, gamma entrainment was identified as a significant predictor of gamma propagation (p < 0.001). Furthermore, the study identified white matter microstructural integrity as a significant predictor of gamma propagation by flickering light stimulation (p < 0.05), which was specific to tracts that connect occipital and temporal or frontal regions. These findings indicate that, despite robust entrainment of gamma rhythms in the visual cortex, their propagation to other regions may be impaired if the microstructural integrity of the white matter tracts connecting the visual cortex to other areas is compromised. Consequently, our findings have expanded our understanding of the prerequisites for effective gamma entrainment and suggest that future clinical trials utilizing visual stimulation for gamma entrainment should consider white matter tract microstructural integrity for candidate selection and outcome analysis.

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Evolution of brain network dynamics in early Parkinson’s disease with mild cognitive impairment

et al. 2022

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Age-related differences in network structure and dynamic synchrony of cognitive control

Cited by 16 publications

References 67 publications

When the time is right: Temporal dynamics of brain activity in healthy aging and dementia

When the time is right: Temporal dynamics of brain activity in healthy aging and dementia

White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans

Evolution of brain network dynamics in early Parkinson’s disease with mild cognitive impairment

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