Age-related differences in hair trace elements: a cross-sectional study in Orenburg, Russia

Skalnaya, Margarita G.; Tinkov, Alexey A.; Demidov, V. A.; Serebryansky, Eugeny P.; Nikonorov, Alexandr А.; Skalny, Anatoly V.

doi:10.3109/03014460.2015.1071424

Cited by 31 publications

(22 citation statements)

References 39 publications

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“…2). Similar in the study by Skalnaya et al (2016), the content of Hg in hair was increased in men with age. Furthermore, considering all patients (Fig.…”

Section: Discussionsupporting

confidence: 89%

“…Michalak et al (2014) reported an increase in Hg content of hair samples with age (examined age groups: from 0 to 10 years old to >60 years old). Skalnaya et al (2016) obtained significantly higher content of Hg in hair samples in patients over 30 years of age compare to younger patients (age group 10–29 years old). Also, the study by McDowell et al (2004) showed an increase in mercury content in hair with age (examined age groups: from 1 to 5 years old to 16–49 years old).…”

Section: Discussionmentioning

confidence: 96%

“…One of the proposed mechanisms is linked to impaired excretion of mercury, for which the main way of excretion is its secretion into the gastrointestinal tract and urine. Taking to consideration that aging is linked with reduction of liver and renal functions, the dysfunctions of these organs may lead to damaged mercury excretion (Skalnaya et al 2014, 2016). …”

Section: Discussionmentioning

confidence: 99%

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An analysis of factors affecting the mercury content in the human femoral bone

Zioła-Frankowska

Dąbrowski

Kubaszewski

et al. 2016

Environ Sci Pollut Res

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The study was carried out to determine the content of mercury in bone tissue of the proximal femur (head and neck bone) of 95 patients undergoing total hip replacement due to osteoarthritis, using CF-AFS analytical technique. Furthermore, the investigations were aimed at assessing the impact of selected factors, such as age, gender, tobacco smoking, alcohol consumption, exposure to chemical substance at work, type of degenerative changes, clinical evaluation and radiological parameters, type of medications, on the concentration of mercury in the head and neck of the femur, resected in situ. Mercury was obtained in all samples of the head and neck of the femur (n = 190) in patients aged 25-91 years. The mean content of mercury for the whole group of patients was as follows: 37.1 ± 35.0 ng/g for the femoral neck and 24.2 ± 19.5 ng/g for the femoral head. The highest Hg contents were found in femoral neck samples, both in women and men, and they amounted to 169.6 and 176.5 ng/g, respectively. The research showed that the mercury content of bones can be associated with body mass index, differences in body anatomy, and gender. The uses of statistical analysis gave the possibility to define the influence of factors on mercury content in human femoral bones.

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“…2). Similar in the study by Skalnaya et al (2016), the content of Hg in hair was increased in men with age. Furthermore, considering all patients (Fig.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An analysis of factors affecting the mercury content in the human femoral bone

Zioła-Frankowska

Dąbrowski

Kubaszewski

et al. 2016

Environ Sci Pollut Res

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“…Similar results were obtained when comparing the values of the metal concentration between male (median 0.222 mg/kg for 10–19 years old and 0.241 mg/kg for 20–29 years old) and female (median 0.261 mg/kg for 10–19 years old and 0.298 mg/kg for 20–29 years) of the Orenburg Region. Also, in the study in question, it was found that gender differences in the levels of trace elements, including mercury, were less pronounced with age ( Skalnaya et al., 2015 ). The opposite trend was observed when studying the mercury content in the hair of Polish students - in males (mean 0.216 mg/kg), the metal concentration is higher than in females (mean 0.204 mg/kg) ( Chojnacka et al., 2010 ).…”

Section: Discussionmentioning

confidence: 89%

Factors affecting the mercury concentration in the hair of young residents of the Vologda region, Russia

Aleksina

Komov

2020

Heliyon

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The main aim of this study was to assess the level of mercury accumulation in the hair of students studying in the Vologda Region, Russia. Particular attention is devoted to clarifying the relationship between the metal concentration in the hair and the amount of fish in the diet. It was found that the mercury content in the hair of Vologda Region residents aged 17–21 is in the range from less than 0.002 mg/kg to 1.69 mg/kg, the median of the indicator for the entire sample is 0.14 mg/kg. The median value of mercury content in the hair of males (0.12 mg/kg) is lower than in the hair of females (0.16 mg/kg). The lowest metal concentrations were observed in individuals living in the city of Cherepovets and the highest metal concentration among the entire sample and in females in the western areas, and males in the eastern areas of the Vologda Region. The concentration of metal in the hair of the urban population is lower than in subjects living in rural areas. A higher metal content in the hair was recorded in individuals whose diet usually contains fish twice a month.

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“…[25][26][27][28] However, only limited information is available on the age-and gender-related differences in the elements in the scalp hair of diabetic subjects. 10,15) Furthermore, renal disorders and hypertension, which are most common complications associated with diabetes, affect the levels of elements in the hair of diabetic subjects.…”

Section: Discussionmentioning

confidence: 99%

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Hotta

Fujino

Kimura

et al. 2018

Biological & Pharmaceutical Bulletin

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Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glycated hemoglobin (HbA1c) ranging between 6.2 and 14.4%. The levels of Zn, Cu and Cr in the diabetic subjects (HbA1c>7) were significantly lower than those in the control subjects (p<0.05), and these concentrations decreased significantly with increases in HbA1c (p<0.01). The levels of Fe and Mg in the diabetic subjects were insignificantly lower, and the concentration of Fe decreased significantly with increases in HbA1c (p<0.05) and the concentration of Mn tended to decrease (p<0.10). In contrast, the concentration of As tended to increase with increases in HbA1c ( p<0.10). The concentrations of other elements, such as Ca, Mn, V, Pb, Cd and Hg, in the diabetic subjects were similar to those of control subjects, and did not correlate with HbA1c. The average of estimated glomerular filtration rate (eGFR) in the diabetic subjects was 77.7 29.7 mL/min/1.73 m 2 with large variation (12.7-148 mL/min/1.73 m 2 ), and previous study reported the increase of urinary excretion of Zn, Cr, Mn and Mg in diabetic subjects. The decreases of Zn, Cu, Cr, Fe and Mg concentrations in hair may reflect increased urinary excretion of these elements due to diabetic nephropathy.Key words diabetes; scalp hair; glycated hemoglobin (HbA1c); zinc; chromium; copper Diabetes mellitus is a serious and chronic metabolic disorder. Type 2 diabetes results from a disruption in glucose metabolism associated with a reduction in insulin production and utilization by tissues. Glycated hemoglobin (HbA1c) levels are used for screening and diagnostic purposes as HbA1c indicates the quality of blood glucose control over the previous 1-2 or 2-3 months. A HbA1c (%) value greater than 6.5 is a cut-off point for diabetic subjects and is highly prognostic for longterm diabetes-related complications such as nephropathy, retinopathy and neuropathy, and maintenance of the HbA1c value below 7.0 is a therapeutic guideline for the prevention of such complications of the Japan Diabetic Society. Estimated glomerular filtration rate (eGFR) is used for screening for nephropathy. The glomerular filtration rate (GFR) generally decreases as diabetes progresses, but the early stage of diabetic nephropathy is characterized by hyperfiltration (increase of GFR). 1) Deficiencies in trace elements such as Cr, Zn, Cu, Mg and Mn have been shown to predispose a person to glucose tolerance and to promote the development of diabetic complications. 2,3) Insulin resistance (IR) is defined as the condition in which insulin sensitive tissues become numb to insulin reception, and a Cr deficiency can induce IR. 2) Zn is known to synthesize insulin as well as stabilize insulin that has been stored in the beta cells of the pancreas. 4) Further, Zn has an important role in the sec...

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Age-related differences in hair trace elements: a cross-sectional study in Orenburg, Russia

Cited by 31 publications

References 39 publications

An analysis of factors affecting the mercury content in the human femoral bone

An analysis of factors affecting the mercury content in the human femoral bone

Factors affecting the mercury concentration in the hair of young residents of the Vologda region, Russia

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

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