Age‐related differences in collagen crimp patterns in the superficial digital flexor tendon core region of untrained horses

Patterson-Kane, Janet C.; Firth, E. C.; Goodship, Allen E.

doi:10.1111/j.1751-0813.1997.tb13829.x

Cited by 83 publications

(67 citation statements)

References 17 publications

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“…Generally, the level of critical deformation is high in immature BS2 guinea pigs and then decreases after skeletal maturation at 12 weeks (20), as previously shown in tendon (34,35). Critical deformation in ACLs from DH animals, however, was significantly greater than that in ACLs from BS2 animals at 12, 16, and 24 weeks of age (P Ͻ 0.001 for all ages).…”

Section: Biomechanicsmentioning

confidence: 61%

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Quasnichka¹,

Anderson-MacKenzie²,

Tarlton³

et al. 2005

Arthritis & Rheumatism

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Objective. The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary OA. Additionally, femoral notch narrowing at the anterior cruciate ligament (ACL) insertion site is associated with disease severity, but it is unknown whether ligament deterioration precedes or follows osteophyte formation. We examined cruciate ligament mechanics and metabolism and the intercondylar notch width in OAprone Dunkin-Hartley (DH) guinea pigs at ages up to and including the age at OA onset (24 weeks), and compared the data with those in age-matched controls (Bristol strain 2 [BS2] guinea pigs).Methods. Guinea pigs were assessed at 3, 6, 9, 12, 16, 20, 24, and 36 weeks of age. ACLs were mechanically tested, and the intercondylar notch width index (NWI) was determined. Cruciate ligament metabolism was determined by measuring the following markers of collagen turnover: matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 2, C-terminal type I procollagen propeptide (PICP), and the immature collagen-derived crosslink dihydroxylysinonorleucine (DHLNL).Results. DH guinea pigs had significantly laxer ACLs than did BS2 guinea pigs, at 12, 16, and 24 weeks. We observed elevated levels of pro and active MMP-2, PICP, and DHLNL in the cruciate ligaments of DH animals at most ages, compared with BS2 guinea pigs. The NWI in DH animals was significantly lower than that in BS2 guinea pigs at 24 and 36 weeks.Conclusion. In DH guinea pigs, laxer ACLs, which are associated with increased collagen turnover, may cause joint instability and predispose these animals to the early onset of OA. Decreased intercondylar notch width in the DH animals indicates that bone remodeling at the ACL insertion site is a response to elevated ACL laxity.

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Section: Biomechanicsmentioning

confidence: 61%

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Quasnichka¹,

Anderson-MacKenzie²,

Tarlton³

et al. 2005

Arthritis & Rheumatism

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“…This is in contrast to the current study, which did not identify any alterations in core or peripheral fascicle CSA with age. Age-related alterations to the collagenous component of the SDFT, such as decreased crimp angle (Patterson-Kane et al, 1997), increased type III collagen content (Birch et al, 1999) and accumulation of advanced glycation end-products and partially degraded collagen (Thorpe et al, 2010b) might be expected to result in altered fascicle mechanical properties. While no age-related alterations in the failure properties of SDFT fascicles were identified in the current study, it is possible that compositional changes may alter other parameters, such as visco-elastic behaviour and fatigue resistance.…”

Section: Discussionmentioning

confidence: 99%

Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy?

Thorpe

Udeze²,

Birch³

et al. 2013

eCM

118

156

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Age-related tendinopathy is common in both humans and horses; the initiation and progression of which is similar between species. The majority of tendon injuries occur to high-strain energy storing tendons, such as the human Achilles tendon and equine superficial digital flexor (SDFT). By contrast, the low-strain positional human anterior tibialis tendon and equine common digital extensor (CDET) are rarely injured. It has previously been established that greater extension occurs at the fascicular interface in the SDFT than in the CDET; this may facilitate the large strains experienced during locomotion in the SDFT without damage occurring to the fascicles. This study investigated the alterations in whole tendon, fascicle and interfascicular mechanical properties in the SDFT and CDET with increasing age. It was hypothesised that the amount of sliding at the fascicular interface in the SDFT would decrease with increasing horse age, whereas the properties of the interface in the CDET would remain unchanged with ageing. Data support the hypothesis; there were no alterations in the mechanical properties of the whole SDFT or its constituent fascicles with increasing age. However, there was significantly less sliding at the fascicular interface at physiological loads in samples from aged tendons. There was no relationship between fascicle sliding and age in the CDET. The increase in stiffness of the interfascicular matrix in aged SDFT may result in the fascicles being loaded at an earlier point in the stress strain curve, increasing the risk of damage. This may predispose aged tendons to tendinopathy.

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“…A imagem ultra-sonográfica de tendões sadios no corte longitudinal apresenta os feixes de fibras como linhas longitudinais paralelas ecogênicas e como pontos ecogênicos homogêneos uniformemente distribuídos no corte transversal (REEF et al, 1988;NICOLL et al, 1993;MAAR et al, 1993). De acordo com CUESTA et al (1995), a adaptação ao exercício resulta em diminuição da ecogenicidade.…”

Section: Introductionunclassified

Relevância da ultra-sonografia dos tendões flexores em cavalos Puro Sangue de corrida na adaptação ao treinamento

Greig

Brass

Oliveira³

et al. 2005

Cienc. Rural

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Age‐related differences in collagen crimp patterns in the superficial digital flexor tendon core region of untrained horses

Cited by 83 publications

References 17 publications

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy?

Relevância da ultra-sonografia dos tendões flexores em cavalos Puro Sangue de corrida na adaptação ao treinamento

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