Age-related differences in appetitive trace conditioning and novel object recognition procedures

Marshall, Hayley J.; Pezze, Marie A.; Fone, Kevin C. F.; Cassaday, Helen J.

doi:10.1016/j.nlm.2019.107041

Cited by 7 publications

(4 citation statements)

References 64 publications

(114 reference statements)

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“…However, the performance was not different from the chance at 18 months, indicating impaired recognition, despite no age-related difference in time exploring the objects. Similarly, other longitudinal studies find improvements due to previous training (Chiquita et al, 2019;Marshall et al, 2019). Thus, previous experience influences performance possibly due to positive transfer.…”

Section: Perirhinal Cortex Based Tasks Novel Object Recognitionmentioning

confidence: 76%

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

McQuail

Dunn

Stern

et al. 2021

Front. Aging Neurosci.

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The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.

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Section: Perirhinal Cortex Based Tasks Novel Object Recognitionmentioning

confidence: 76%

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

McQuail

Dunn

Stern

et al. 2021

Front. Aging Neurosci.

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“…In a longitudinal study of ageing male Wistar rats, we found that object exploration was overall reduced in middle aged rats and was further reduced when the rats were 6 months older. However, an initial NOR impairment (seen at a 24hr but not at a 10 min retention interval) showed recovery at the second point of testing [20] . These findings suggest that any strain differences by age seen cross-sectionally could similarly be overcome with enriched housing conditions and regular handling.…”

Section: Discussionmentioning

confidence: 89%

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures

Waite

Bonardi

Stevenson

et al. 2021

Physiology & Behavior

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Highlights Behavioural comparisons of albino Wistar and pigmented Lister Hooded rats. Within-subjects inhibitory learning ( A +/AX-) and novel object recognition variants. Wistars showed clearer inhibitory discrimination than Lister Hooded rats. Novel object recognition discriminations showed strain differences in consistency. Wistars are good for associative learning and basic object recognition procedures.

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“…The Novel Object Recognition (NOR) test was carried out to evaluate recognition memory (non-spatial working memory) [30,31]. The NOR test was performed according to a previously published method [32].…”

Section: Novel Object Recognition Testmentioning

confidence: 99%

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

Tang¹,

Duan²,

Ge³

et al. 2022

J. Integr. Neurosci.

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Background: One of the most serious complications of sepsis is sepsis-associated encephalopathy (SAE), which impairs the cognition ability of survivors. Environmental enrichment (EE) has been demonstrated to alleviate cognition deficits under many kinds of brain injury conditions. However, EE's effects on SAE remain unknown. Therefore, this study aimed to determine EE's effect on cognition disorders under SAE conditions and the underlying mechanism. Materials and Methods: Adult male rats, subject to SAE or not, were housed under a standard environment (SE) or EE for 30 days. Subsequently, the rats were subjected to cognitive tests, such as the novel object recognition (NOR) test, the Morris water maze (MWM) test, an Open Field (OF) test, the elevated plus maze (EPM) test, and a sensory neglect (SN) test. Neuroinflammation, apoptosis, and oxidative stress changes in the brain were also detected. Results: The results revealed that SAE impaired somatesthesia, recognition memory, spatial learning and memory, and exploratory activity, which were significantly improved by EE housing. EE also prevented SAE-induced anxiety-like behavior. In addition, EE housing capable induced a decrease in pro-inflammatory cytokines, and an increase in anti-inflammatory cytokines and antioxidant properties in the brain. Moreover, EE housing exerted an anti-apoptosis function by upregulating the level of B-cell lymphoma/leukemia-2 (Bcl-2) level and downregulating the level of p53 level in the hippocampus. Conclusions: The results of the present study indicated that EE exerts a neuroprotective function on cognitive ability in SAE rats. The effect is achieved by increasing antioxidants, and anti-inflammatory and antiapoptotic capacities. EE can effectively rescue SAE-induced cognitive deficits.

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Age-related differences in appetitive trace conditioning and novel object recognition procedures

Cited by 7 publications

References 64 publications

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

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