Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression

Dallaway, Alexander David Francis; Kite, Chris; Griffen, Corbin; Duncan, Michael; Tallis, Jason; Renshaw, Derek; Hattersley, John

doi:10.1016/j.exger.2020.110856

Cited by 28 publications

(13 citation statements)

References 187 publications

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“…A decrease in the CSA indicates muscle atrophy and an increase in the FIR reflects muscle degeneration (11). It has been reported that the CSA of the PVMs significantly decreased, while the FIR of the PVMs increased in patients with LBP (27,28).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

et al. 2020

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The present study aimed to determine the characteristics of multifidus, erector spinae and psoas major degeneration in elderly patients with degenerative lumbar scoliosis (DLS) and the correlation between asymmetric changes and patient quality of life. A total of 49 patients with lumbar scoliosis (DLS group) and 38 healthy individuals (control group) were prospectively examined. The functional cross-sectional area, cross-sectional area difference index (CDI) and fat infiltration rate (FIR) of the multifidus, erector spinae and psoas major at the apical vertebral level were measured using MRI. The visual analogue scale (VAS) score, Oswestry Disability Index (ODI) and 36-item Short Form Health Survey (SF-36) score were used to evaluate patient quality of life. Correlations between the degree of asymmetric muscular degeneration and quality of life were analysed. The CDI of the multifidus, erector spinal and psoas major was higher in the DLS group compared with that in the control group. The CDI of the multifidus was found to be positively associated with the Cobb angle of lumbar scoliosis. Similar results were obtained for fat infiltration between the two groups. In addition, the CDI and FIR difference index of the multifidus was positively correlated with the VAS score and ODI but negatively correlated with the SF-36 score. The quality of life significantly decreased with increasing asymmetric atrophy and fat infiltration in the multifidus. Thus, strategies to enhance the function of the multifidus may have a positive impact on quality of life (Chinese Clinical Trial Registry, registration date, 2018.11.12; registration no. ChiCTR1800019459.).

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Section: Discussionmentioning

confidence: 99%

“…These are important components of the dynamic spinal stabilization system that provide the power of trunk movements (10). PVM degeneration is characterized by increased fat infiltration and decreased muscle volume (11). PVM degeneration is associated with various lumbar diseases and post-operative complications (12,13).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

et al. 2020

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“…The results show that healthy males experience a loss of concentric extensor torque with ageing in the trunk. As the proportion of contractile tissue in the lumbar paravertebral muscles decreases due to age-related atrophy and fat infiltration (Dallaway et al, 2020), the muscles' capacity to generate force and perform work is reduced (Ropponen, Videman, & Battié, 2008). However, lean trunk mass was greater in the older group than the younger group in this study.…”

Section: Loss Of Extensor Concentric Torquementioning

confidence: 49%

Age-Related Changes in Concentric and Eccentric Isokinetic Peak Torque of the Trunk Muscles in Healthy Older Versus Younger Men

Dallaway¹,

Hattersley²,

Tallis³

et al. 2021

Journal of Aging and Physical Activity

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This study investigated age-related changes in trunk muscle function in healthy men and the moderating effect of physical activity. Twelve older (67.3 ± 6.0 years) and 12 younger (24.7 ± 3.1 years) men performed isokinetic trunk flexion and extension tests across a range of angular velocities (15°/s–180°/s) and contractile modes (concentric and eccentric). For concentric trunk extension, mixed-effects analysis of covariance revealed a significant interaction between Angular velocity × Age group (p = .026) controlling for physical activity. Follow-up univariate analysis of covariance revealed that the younger group produced significantly greater peak torque for all concentric extension conditions. Eccentric trunk strength was somewhat preserved in the older group. Age-related changes in trunk strength were independent of physical activity. The normal loss of trunk muscle strength in older age is muscle- and contractile-mode specific. These findings provide guidance for effective intervention strategies to offset adverse health outcomes related to trunk strength loss in older adults.

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“…Age and disease duration were determined to have a significant positive correlation ( r = 0.528, p < 0.001). Since increased fat deposition in paraspinal muscles has been studied throughout aging [ 37 ], partial correlation testing was then performed with age as a control variable for FF and disease duration, and no significant link was found in both MF and ES at all levels (all p > 0.05). A weak to moderate negative correlation was obtained between the mean CSA in MF at both L3/L4 and L4/L5 levels and ESR ( r = − 0.503 and − 0.409, all p < 0.05, respectively).…”

Section: Resultsmentioning

confidence: 99%

T2 mapping and fat quantification of lumbar paraspinal muscle in ankylosing spondylitis: a case control study

Huang

Yang

Chen

et al. 2022

BMC Musculoskelet Disord

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Background To compare changes in the composition of paraspinal muscles of patients with ankylosing spondylitis (AS) and matched healthy controls using T2 mapping and T2 IDEAL and correlate the quantitative magnetic resonance imaging (qMRI) results with clinical assessments of AS patients. Method In total, 37 AS patients and 37 healthy controls were enrolled in the case control study. T2 mapping with and without fat saturation and IDEAL imaging were used to assess the multifidus (MF) and erector spinae (ES) at the levels of L3/L4 and L4/L5 for all subjects. Mean T2non-fatsat, T2fat, T2fatsat, cross-sectional area (CSA), and fat fraction (FF) were compared between AS and healthy controls. Correlations of qMRI results with clinical assessments were analyzed in AS. Results Significantly elevated mean T2non-fatsat values and the FF of the MF and ES at both levels were observed in AS and compared to the controls (p < 0.05). The mean T2fatsat values of ES and MF were significantly higher only at the level of L3/L4 in AS compared to healthy controls (p < 0.05). A loss of muscle CSA compatible with atrophy was present in MF and ES at both levels in AS compared to the controls (p < 0.05). Weak to moderate positive correlations were found between FF and age and disease duration in AS (r = 0.318–0.415, p < 0.05). However, such positive correlation was not observed between FF and disease duration after adjusting for age (p > 0.05). Conclusions Our findings indicate that using a combination of IDEAL and T2 mapping may provide deeper insights into the pathophysiological degeneration of paraspinal muscles in AS.

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Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression

Cited by 28 publications

References 187 publications

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

Age-Related Changes in Concentric and Eccentric Isokinetic Peak Torque of the Trunk Muscles in Healthy Older Versus Younger Men

T2 mapping and fat quantification of lumbar paraspinal muscle in ankylosing spondylitis: a case control study

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