Age-related degeneration of corpus callosum measured with diffusion tensor imaging

Ota, Miho; Obata, Takayuki; Akine, Yoshihide; Ito, Hiroshi; Ikehira, Hiroo; Asada, Takashi; Suhara, Tetsuya

doi:10.1016/j.neuroimage.2006.02.008

Cited by 186 publications

(166 citation statements)

References 51 publications

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“…Our finding adds evidence to previous observations in children and adolescents, in which there were age-related FA changes in the splenium of the corpus callosum, as well as in the corticospinal tract and the internal capsule. 16 Our results are consistent with recent findings for the corpus callosum, 29,30 as well as with those of other authors who reported a decrease in the FA and a concomitant increase in the apparent diffusion coefficient as adults age. 31,32 This may be attributed to a gradual demyelination, loss of neural attenuation, changes in water content, or changes in the organization of nerve fibers.…”

Section: Discussionsupporting

confidence: 93%

Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Bisdas¹,

Bohning²,

Bešenski³

et al. 2008

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 93%

Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Bisdas¹,

Bohning²,

Bešenski³

et al. 2008

AJNR Am J Neuroradiol

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“…This is consistent with previous studies. For example, Ota and colleagues observed that the age was negatively correlated with FA values particularly in the genu and in the rostral body of the CC (which correspond with our prefrontal CC area) (30). Others have taken this notion further by claiming that the APOE ε4 allele acts as a potential modulator of normal brain aging, accelerating cortical degeneration especially in the medial prefrontal and pericentral cortex (31).…”

Section: Discussionmentioning

confidence: 99%

Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE ϵ4 carriers

Filippini

Zarei

Beckmann

et al. 2009

Magnetic Resonance Imaging

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Purpose:To investigate the possible effect of the APOE ε4 allele on age-related regional volume loss within the corpus callosum (CC) in healthy ε4 allele carriers compared with noncarriers. Materials and Methods:A total of 211 subjects, ages 27 to 83 years, 51 ε4 carriers and 160 noncarriers underwent T1-weighted MRI scan. All subjects had normal MRI scan and performed within normal range on a neuropsychological battery of tests. CC was segmented into seven functionally relevant regions using a previously published probabilistic map of the CC connectivity. We measured the volumes of the CC and its subregions. We used a regression model (with volumes as dependent and age as independent variables) and compared the slopes between carriers and noncarriers using an analysis of covariance model. We also carried out voxel-based-morphometry analysis to investigate the possible effect of the APOE ε4 gene on the gray matter. Results:We found that the volume of the CC and all subregions decreased with increasing age in both groups. The slope was steeper in the APOE ε4 carriers compared withthe noncarriers particularly in the prefrontal region (P ϭ 0.02). No gray matter differences were observed between the two groups.Conclusion: APOE ε4 polymorphism is associated with accelerated age-related volume loss in the prefrontal callosal tracts without gray matter loss. This result suggests the role of APOE ε4 in the brain aging by primarily affecting white matter structures particularly in the frontal lobe.

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“…To obtain a comprehensive picture of differences in different elements of WM microstructure, however, it is necessary to consider conjointly all measures derived from the diffusion tensor (Assaf and Pasternak, 2008). This has not been done systematically in previous research; few studies have reported eigenvalues for selected WM structures (Abe et al, 2002;Bhagat and Beaulieu, 2004;Hsu et al, 2008;Ota et al, 2006;Stadlbauer et al, 2008;Sullivan et al, 2006b), and only one tractography-based study reported the values of MD, RD, and AD for all main cerebral WM tracts in adults between 20 and 81 years of age (Sullivan et al, in press). The diffusivities were, however, not analyzed conjointly and studying a mean value for the whole tract does not use the localized information of diffusivity properties obtained for each voxel given that the age effect on diffusivity properties may not be uniform along a WM tract.…”

Section: Introductionmentioning

confidence: 99%

Age-related differences in white matter microstructure: Region-specific patterns of diffusivity

Burzynska¹,

Preuschhof²,

Bäckman³

et al. 2010

NeuroImage

345

339

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We collected MRI diffusion tensor imaging data from 80 younger (20-32 years) and 63 older (60-71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that white matter integrity, as indicated by decreased fractional anisotropy (FA), was disrupted in numerous structures in older compared to younger adults. These regions displayed five distinct region-specific patterns of age-related differences in other diffusivity properties: (1) increases in both radial and mean diffusivity; (2) increases in radial diffusivity; (3) no differences in parameters other than FA; (4) a decrease in axial and an increase in radial diffusivity; and (5) a decrease in axial and mean diffusivity. These patterns suggest different biological underpinnings of agerelated decline in FA, such as demyelination, Wallerian degeneration, gliosis, and severe fiber loss, and may represent stages in a cascade of age-related degeneration in white matter microstructure. This first simultaneous description of age-related differences in FA, mean, axial, and radial diffusivity requires histological and functional validation as well as analyses of intermediate age groups and longitudinal samples.

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Age-related degeneration of corpus callosum measured with diffusion tensor imaging

Cited by 186 publications

References 51 publications

Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE ϵ4 carriers

Age-related differences in white matter microstructure: Region-specific patterns of diffusivity

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