Age-Related Decreases in Plasma Adrenocorticotropic Hormone, Corticosterone, and Aldosterone Responses to Exogenous Corticotropin-Releasing Hormone in the Rat

Brudieux, R; Chaoui, A.; Rakotondrazafy, J.

doi:10.1159/000213700

Cited by 13 publications

(4 citation statements)

References 19 publications

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“…In the present study, we compared adult rats with old animals, while other authors have studied developmental phenomena by comparing young rats with aged animals which were not sufficiently old. In a previous report [29], we have discussed why we think that our results reflect essentially age-related effects rather than pathological phenomena associated with very old age.…”

Section: Discussionmentioning

confidence: 68%

Age-Related Changes in Secretion and Metabolic Effects of Atrial Natriuretic Factor in Rats

Rakotondrazafy¹,

Davicco²,

Barlet³

et al. 1996

Gerontology

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The effects of aging on the secretion of and renal sensitivity to atrial natriuretic factor (ANF) were studied concomitantly in both senescent (25- to 34-month-old) and in adult (7- to 13-month-old) female and male Long-Evans rats. The plasma concentrations of ANF, measured in response to either a mild stimulation induced by a hypertonic volume expansion (i.e., 20 min after the onset of a continuous infusion during 15 min of a 2.5% NaCl solution; n = 18 old and 23 adult rats) or an intense stimulation produced by morphine injection (i.e., 30 min after an intraperitoneal injection of 5 mg morphine/100 g body weight; n = 11 old and 12 adult rats), were significantly lower (approximately -34 and -80%, respectively) in old as compared with adult animals. Acute intravenous injection of exogenous rat ANF (0.10 and 0.40μg/l00g body weight) induced similar natriuretic, diuretic, and kaliuretic effects in aged (n = 18) and in adult (n = 23) rats. The present data suggest that the significantly reduced (about -20%) natriuretic and kaliuretic responses of the aged rat, observed 20 min after the onset of hypertonic volume expansion, could be partly due to a primary defect in cardiac production and/or release of ANF rather than to a reduction of renal responsivity to ANF.

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Section: Discussionmentioning

confidence: 68%

Age-Related Changes in Secretion and Metabolic Effects of Atrial Natriuretic Factor in Rats

Rakotondrazafy¹,

Davicco²,

Barlet³

et al. 1996

Gerontology

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“…Our study was not designed to investigate training effects on amelioration of the stress response. It is possible that changes in corticosterone levels after the training regimen may be simply be occurring due to the passage of time (Brudieux, Ait Chaoui, & Rakotondrazafy, ). We hypothesize, however, that one potential explanation for the observed changes in plasma corticosterone levels and amelioration of stress‐sensitive behavioral and HPA differences across groups is the robust training, handling, and cognitive enrichment provided to all animals to implement the ASST task.…”

Section: Discussionmentioning

confidence: 99%

The influence of early maternal care on perceptual attentional set shifting and stress reactivity in adult rats

Sakhai

Saxton

Francis

2015

Developmental Psychobiology

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Stress influences a wide variety of outcomes including cognitive processing. In the rat, early life maternal care can influence developing offspring to affect both stress reactivity and cognitive processes in adulthood. The current study assessed if variations in early life maternal care can influence cognitive performance on a task, the ability to switch cognitive sets, dependent on the medial prefrontal cortex. Early in life, offspring was reared under High or Low maternal Licking conditions. As adults, they were trained daily and then tested on an attentional set-shifting task (ASST), which targets cognitive flexibility in rodents. Stress-sensitive behavioral and neural markers were assayed before and after the ASST. High and Low Licking offspring performed equally well on the ASST despite initial, but not later, differences in stress axis functioning. These results suggest that early life maternal care does not impact the accuracy of attentional set-shifting in rats. These findings may be of particular importance for those interested in the relationship between early life experience and adult cognitive function.ß 2015 Wiley Periodicals, Inc. Dev Psychobiol

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“… Rakotondrazafy and Brudieux [461] reported that plasma aldosterone incremental response to angiotensin II was significantly lower in aged (28-32-mo) female Long-Evans rats than in adult (8-10-mo) rats.  Brudieux et al, [462] examined age-related changes in plasma corticosterone and aldosterone responses to exogenous corticotrophin-releasing hormone (CRH) in female Long-Evans rats. Basal plasma corticosterone and aldosterone levels did not differ between young adult (7-9-mo) and aged (30-35-mo) rats.…”

Section: Long-evans (Le) Ratsmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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Age-Related Decreases in Plasma Adrenocorticotropic Hormone, Corticosterone, and Aldosterone Responses to Exogenous Corticotropin-Releasing Hormone in the Rat

Cited by 13 publications

References 19 publications

Age-Related Changes in Secretion and Metabolic Effects of Atrial Natriuretic Factor in Rats

Age-Related Changes in Secretion and Metabolic Effects of Atrial Natriuretic Factor in Rats

The influence of early maternal care on perceptual attentional set shifting and stress reactivity in adult rats

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

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