Age-related declines to serum prestin levels in humans

Parker, Ashley; Parham, Kourosh; Skoe, Erika

doi:10.1016/j.heares.2022.108640

Cited by 7 publications

(12 citation statements)

References 70 publications

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“…The finding of age-related increase in prestin level appears to differ from our recent report of age-related decrease [18]. There is an important difference in the study populations of the two studies.…”

Section: Discussioncontrasting

confidence: 97%

“…Young adults at risk of noise-induced hearing loss were distinguished from their not-atrisk peers by their prestin levels when OAE levels were the same [17]. We have also found age-related effects in prestin levels in normal hearing older adults [18].…”

Section: Discussionsupporting

confidence: 55%

“…More studies are needed in humans to establish the parameters that influence serum prestin. We have shown its reliability and stability over time [16], negative correlation with daily noise exposure [17] in normal hearing young adults, and its decline with age per se [18]. Recognizing that previous experimental research demonstrated that OHCs provide 40-60 dB of sensitivity [19], here, we examine serum prestin levels in chronic sensorineural hearing loss (SNHL) in relation to the severity of hearing loss, controlling for age.…”

Section: Introductionmentioning

confidence: 92%

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Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss

Al Samarrai,

Mahdi,

Parham

2024

Cureus

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Objective: Prestin is an outer hair cell (OHC) protein responsible for increasing cochlear sensitivity and has been proposed as a biomarker. We aimed to evaluate whether the serum prestin level is related to the severity of chronic sensorineural hearing loss (SNHL).Methods: Ninety subjects were recruited from the patient base at Samarra public hospitals and clinics in Iraq from January to October of 2022. They were divided into three groups equally: a group of healthy people without hearing loss (G0), a group with moderate SNHL (G1), and a group with severe SNHL (G2). The subjects ranged from 20 to 80 years of age and included 51 males and 39 females. Blood samples were collected, then serum was separated, and enzyme-linked immunosorbent assays were performed to quantify the levels of prestin.Results: Hearing thresholds were sequentially statistically higher across the three groups. While prestin levels were significantly higher in G1 and G2 than that in G0, there were no differences between the G1 and G2 levels. Serum prestin levels were positively correlated with hearing thresholds in G1, but not G2. Conclusion:Our results suggest that in the clinical setting, prestin is sensitive to chronic mild to moderate SNHL (i.e., up to 40-60 dB), not more severe loss. This range is consistent with the added sensitivity provided by OHCs in the cochlea and provides support for prestin as a biomarker of OHC-mediated SNHL.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 92%

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Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss

Al Samarrai,

Mahdi,

Parham

2024

Cureus

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“… 23 In addition, serum prestin levels declined with increasing levels of hearing loss. 15 Sun et al investigated the role of prestin levels in the patients with idiopathic sudden SNHL and found the baseline prestin levels in the control patients as 840.24 ± 496.22 pg/mL. 14 In our study, in the mastoidectomy group, the baseline serum prestin level (preoperatively) was 645.53 ± 516.45 pg/mL and in the myringoplasty group, it was 555.7 ± 259.4 pg/mL.…”

Section: Discussionsupporting

confidence: 51%

“… 10 , 11 , 12 Several human studies have investigated the prestin levels in patients with different kinds of hearing loss such as noise-induced, sudden, or SNHL. 13 , 14 , 15 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels

Baskadem Yilmazer,

Tanrısever,

Alagoz

et al. 2024

Brazilian Journal of Otorhinolaryngology

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Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss

Gadenstaetter,

Krumpoeck,

Auinger

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveDetermining the concentration of prestin in human blood, cerebrospinal fluid (CSF), and perilymph (PL), and evaluating its suitability as a clinical biomarker for sensori‐neural hearing loss (SNHL).Study DesignHuman blood, CSF, and PL samples were intraoperatively collected from 42 patients with tumors of the internal auditory canal or with intracochlear tumors undergoing translabyrinthine or middle fossa tumor removal. Prestin concentration was measured using enzyme‐linked immunosorbent assay and linear regression analyses were performed to investigate its associations with audiological as well as vestibular test results.SettingTertiary referral center.ResultsThe median prestin concentration in blood samples of the 42 study participants (26 women, mean ± standard deviation age, 52.7 ± 12.5 years) was 1.32 (interquartile range, IQR, 0.71‐1.99) ng/mL. CSF prestin levels were significantly higher with 4.73 (IQR, 2.45‐14.03) ng/mL (P = .005). With 84.74 (IQR, 38.95‐122.00) ng/mL, PL prestin concentration was significantly higher compared to blood (P = .01) and CSF (P = .03) levels. Linear regression analyses showed significant associations of CSF prestin concentration with preoperative hearing levels (pure‐tone average and word recognition; P = .008, R2 = 0.1894; P = .03, R2 = 0.1857), but no correlations with blood or PL levels.Conclusion and RelevanceThis study's findings highlight the volatile nature of prestin levels and provide the first insights into this potential biomarker's concentrations in body fluids apart from blood. Future investigations should comprehensively assess human prestin levels with different etiologies of SNHL, prestin's natural homeostasis and systemic circulation, and its temporal dynamics after cochlear trauma. Finally, clinically approved detection kits for prestin are urgently required prior to considering a potential translational implementation of this diagnostic technique.

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Age-related declines to serum prestin levels in humans

Cited by 7 publications

References 70 publications

Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss

Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss

Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels

Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss

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