Age-Related Decline in Reproductive Sensitivity to Inhibition by Short Photoperiod in<i>Peromyscus Leucopus</i>

Broussard, David; Robertson, Jessica; Evans, Tracy J.; Faucher, Gregory K.; Semanik, Michael G.; Heideman, Paul D.

doi:10.1644/07-mamm-a-336.1

Cited by 10 publications

(21 citation statements)

References 25 publications

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“…Detailed descriptions of the selection lines used in this study are available elsewhere (Broussard et al, 2009; Heideman et al, 1999; Heideman & Pittman, 2009); here we provide a brief description. Two artificial selection lines and an unselected control line were established in 1995 from 208 offspring of 48 wild-caught mice.…”

Section: Methodsmentioning

confidence: 99%

“…The control line was maintained as an unselected outbred line, while artificial selection in the responder and nonresponder lines was continued for 10 subsequent generations. When raised under long photoperiod, males and females reach adult body mass at age 70 days, but become sexually mature at age 46–60 days (Broussard et al, 2009). In contrast, when transferred to short photoperiod within 3 days of birth and raised under short photoperiod, males that are affected reproductively by short photoperiod do not begin to become photorefractory until about 18–20 weeks of age (Broussard et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

“…Testes of males in the nonresponder line under short photoperiod are still within the normal range for long photoperiod for the founder population or the control line (Heideman et al, 1999). Additional information on the two selection lines and control line has been published elsewhere (Broussard et al, 2009; Heideman, 2004; Smale, Heideman & French, 2005). …”

Section: Methodsmentioning

confidence: 99%

“…who was blind to both line and treatment. The length and width of the testis was used to estimate testis size (Broussard et al, 2009). The right ear of each male was tagged (Size 1 Monel, National Band and Tag Co., Newport, KY, U.S.A.) as a permanent identification marker.…”

Section: Methodsmentioning

confidence: 99%

“…At the same age, approximately 80% of nonresponder mice had large gonads under short photoperiod, and gonads were similar in size to mice raised under long photoperiod (LD 16:8 h) in a control line (Heideman & Pittman, 2009). Both selection lines undergo reproductive suppression under short relative to long photoperiod (Heideman & Pittman, 2009), but only in the responder line does reproductive suppression under short photoperiod commonly result in low levels of spermatozoa: azoospermia or oligospermia (Broussard et al, 2009). These selection lines have been shown to differ heritably in reproductive traits (reproductive organ size, number of immunoreactive GnRH neurons, levels of luteinizing hormone: Avigdor, Sullivan & Heideman, 2005; Heideman et al, 1999; Heideman et al, 2010) as well as some, but not all, nonreproductive traits that may affect fertility (ad libitum food intake, metabolic rate, physical activity, amount of iodomelatonin binding in the brain: Heideman & Pittman, 2009; Heideman et al, 2010; Kaseloo, Crowell & Heideman, 2014; Kaseloo, Crowell, Jones & Heideman, 2012; White et al, 2014).…”

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confidence: 99%

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Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

et al. 2015

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In natural populations, genetic variation in seasonal male sexual behaviour could affect behavioural ecology and evolution. In a wild-source population of white-footed mice, Peromyscus leucopus, from Virginia, U.S.A., males experiencing short photoperiod show high levels of genetic variation in reproductive organ mass and neuroendocrine traits related to fertility. We tested whether males from two divergent selection lines, one that strongly suppresses fertility under short photoperiod (responder) and one that weakly suppresses fertility under short photoperiod (nonresponder), also differ in photoperiod-dependent sexual behaviour and responses to female olfactory cues. Under short, but not long, photoperiod, there were significant differences between responder and nonresponder males in sexual behaviour and likelihood of inseminating a female. Males that were severely oligospermic or azoospermic under short photoperiod failed to display sexual behaviour in response to an ovariectomized and hormonally primed receptive female. However, on the day following testing, females were positive for spermatozoa only when paired with a male having a sperm count in the normal range for males under long photoperiod. Males from the nonresponder line showed accelerated reproductive development under short photoperiod in response to urine-soiled bedding from females, but males from the responder line did not. The results indicate genetic variation in sexual behaviour that is expressed under short, but not long, photoperiod, and indicate a potential link between heritable neuroendocrine variation and male sexual behaviour. In winter in a natural population, this heritable behavioural variation could affect fitness, seasonal life history trade-offs and population growth.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

et al. 2015

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Circannual Clocks in Tropical Bats and Heritable Variation in Seasonal Reproductive Timing in Temperate Zone Mice

Heideman

2014

Annual, Lunar, and Tidal Clocks

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Heritable variation in reaction norms of metabolism and activity across temperatures in a wild-derived population of white-footed mice (Peromyscus leucopus)

2014

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Heritable variation in metabolic traits is likely to affect fitness. In this study, white-footed mice from wild-derived photoresponsive [R, infertile in short day length (SD)] and non-photoresponsive (NR, fertile in SD) selection lines were maintained under short-day (SD 8Light:16Dark), sub-thermoneutral conditions (22 or 12 °C). Mice had significantly higher levels of food intake and resting metabolic rates (RMR) at low temperature. RMR differed significantly between lines (greater in NR mice). In contrast to previous work under thermoneutral conditions, there was no significant difference in overall activity or average daily metabolic rates (ADMR) of mice from the two lines. Reduced activity may reflect behavioral changes under cooler conditions (e.g., nest building) reducing the overall energetic cost of fertility (for NR mice). There was no significant difference in maximal rate of oxygen consumption ([Formula: see text]) between lines. R mice had significantly greater brown adipose tissue and white abdominal fat mass due to both line and temperature. Reaction norms for intake, resting metabolism (RMR/BMR) and level of activity from current (12 and 22 °C) and previously published data (28 °C) demonstrate independent effects of genetics (line) and environment (temperature) for resting metabolism, but a clear interaction between these for activity. The results suggest that fertility under winter conditions imposes metabolic costs that are related to the level of reproductive development. Under the coldest conditions tested, however, mice that remained fertile in SD reduced activity, ADMR and food requirements, decreasing the differential between selection lines. Heritable variation in reaction norms suggests a genetic by environment effect that could be subject to selection.

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Age-Related Decline in Reproductive Sensitivity to Inhibition by Short Photoperiod inPeromyscus Leucopus

Cited by 10 publications

References 25 publications

Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

Genetic variation in male sexual behaviour in a population of white-footed mice in relation to photoperiod

Circannual Clocks in Tropical Bats and Heritable Variation in Seasonal Reproductive Timing in Temperate Zone Mice

Heritable variation in reaction norms of metabolism and activity across temperatures in a wild-derived population of white-footed mice (Peromyscus leucopus)

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