Age-related decline in central serotonin transporter availability with [123I]β-CIT SPECT

Dyck, Christopher H. van; Malison, Robert T.; Seibyl, John; Laruelle, Marc; Klumpp, Heide; Zoghbi, Sami S.; Baldwin, Ronald M.; Innis, Robert B.

doi:10.1016/s0197-4580(00)00152-4

Cited by 146 publications

(122 citation statements)

References 25 publications

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“…This result is consistent with the findings of previous studies that reported age-related decline of SERT availability of 3.1-4.2 % per decade in the SERT-rich brain regions in healthy adults [17,18]. So far no in vivo imaging study has been published regarding SERT availability in healthy pediatric/adolescent population.…”

Section: Discussionsupporting

confidence: 93%

Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study

Park

Hwang

Chu

et al. 2015

Nucl Med Mol Imaging

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Purpose Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migrai neurs using F-18-N-(3-fluoropropyl)-2β -carbomethoxy-3β-(4-iodophenyl) nortropane ( Results BP ND at the brainstem was significantly higher in adult migraineurs (n=6, 1.15±0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r= −0.64, p=0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r=0.66, p= 0.02), when age and duration of illness were corrected. Conclusions Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission.[ 18 F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.

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Section: Discussionsupporting

confidence: 93%

Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study

Park

Hwang

Chu

et al. 2015

Nucl Med Mol Imaging

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“…The DA transporter, which functions to regulate synaptic DA availability, is higher in women compared to men (67;79;80). The lack of difference between sexes in one study may be due to the large age range and inclusion of postmenopausal women (81). DA transporter availability does not appear to differ by menstrual cycle phase and fluctuating gonadal hormones (82).…”

Section: Sex Differences In Brain Chemistrymentioning

confidence: 99%

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Cosgrove

Mazure

Staley

2007

Biological Psychiatry

878

615

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Background-Clinical and epidemiologic evidence demonstrates sex differences in the prevalence and course of various psychiatric disorders. Understanding sex-specific brain differences in healthy individuals is a critical first step towards understanding sex-specific expression of psychiatric disorders. Here, we evaluate evidence on sex differences in brain structure, chemistry and function using imaging methodologies, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and structural magnetic resonance imaging (MRI) in mentally healthy individuals.

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“…Age was selected because of its demonstrated effect on 5-HTT density (Van Dyck et al 2000) and effects on character scores . Gender was chosen because it had an effect on 5-HTT binding in our sample as well as in earlier studies (Jovanovic et al 2008).…”

Section: Statistical Analysis Of Roi-based Datamentioning

confidence: 99%

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

et al. 2012

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Tuominen, L.; Salo, J.; Hirvonen, J.; Någren, K.; Laine, P.; Melartin, T.; Isometsä, E.; Viikari, J.; Cloninger, C. R.; Raitakari, O.; Hietala, J.; and Keltikangas-Järvinen, L., ,"Temperament, character and serotonin activity in the human brain: A positron emission tomography study based on a general population cohort." Psychological Medicine. 43,4. 881-894. (2012 Background. The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension ' harm avoidance ' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an ' oversampling ' study design.Method. Subjects consistently in either upper or lower quartiles for the HA trait were selected from a populationbased cohort in Finland (n=2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high-and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BP ND ) in high-and low-HA groups estimated with PET and [ 11 C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([ 11 C]MADAM). In secondary analyses, 5-HTT BP ND was correlated with other TCI dimensions.Results. 5-HTT BP ND did not differ between high-and low-HA groups in the midbrain or any other brain region. This result remained the same even after adjusting for other relevant TCI dimensions. Higher 5-HTT BP ND in the raphe nucleus predicted higher scores in ' self-directedness '.Conclusions. This study does not support an association between the temperament dimension HA and serotonin transporter density in healthy subjects. However, we found a link between high serotonin transporter density and high ' self-directedness ' (ability to adapt and control one's behaviour to fit situations in accord with chosen goals and values). We suggest that biological factors are more important in explaining variability in character than previously thought.

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Age-related decline in central serotonin transporter availability with [123I]β-CIT SPECT

Cited by 146 publications

References 25 publications

Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study

Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

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