Age-related compliance of the lamina cribrosa in human eyes

Albon, Julie; Purslow, Peter P.; Karwatowski, W S S

doi:10.1016/0021-9290(94)91390-0

Cited by 48 publications

(59 citation statements)

References 7 publications

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“…Several studies have suggested that the LC is stiffer in older ONHs. 24,25 This lower elasticity might be the cause of the reduced anterior LC displacement that we found, compared to Lee's study. However, we did not find a correlation between age and structural changes in our series.…”

Section: Discussionmentioning

confidence: 43%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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Section: Discussionmentioning

confidence: 43%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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“…An age-related decline in the compliance of the lamina cribrosa, assessed using confocal scanning ophthalmoscopy, has been documented previously. 20 In certain susceptible eyes, this increase in the age-related thickness in the lamina beams may result in an exaggerated response to changes in intraocular pressure, leading to permanent deformation of the lamina cribrosa, and ultimately resulting in axonal loss.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in the thickness of the human lamina cribrosa

Kotecha¹,

Izadi

Jeffery³

2006

British Journal of Ophthalmology

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Objective: To measure the human lamina cribrosa thickness (LCT) in vitro in fully hydrated specimens and to determine whether there is any association between thickness and age or sex. Methods: 45 fixed human optic nerves, age range 9-90 years, were dissected from the globe and frozen sectioned. The study was divided into two parts: the first investigated the overall change in LCT and cribrosal beam thickness (CBT) with age, and the second divided eyes into two specific age groups (38-49 and 78-87 years) and assessed differences with respect to age and sex. Results: LCT ranged from 345.4 to 555.9 mm between the samples. A positive relationship was found between LCT and age (LCT = 2.416age+365.5, 95% confidence interval (CI) for slope 1.31 to 3.52; r 2 = 0.30, p,0.001). A regional difference in CBT was observed, with beams being thickest at the posterior cribrosa (mean 14.8 (standard deviation (SD) 2.2) mm) and thinnest at the anterior cribrosa (9.8 (SD 2.4) mm). CBT increased with increasing age. Differences related to sex were also found, with females having relatively thinner LCT than males, irrespective of age, but this was not statistically significant. Conclusions: This study shows an increase in human LCT with increasing age. This changing structural property of the lamina cribrosa may have implications for its functioning with respect to compliance and reversibility, and has particular relevance to glaucoma, where increasing age has been identified as a strong risk factor for the development of the disease.

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“…The high imaging speed allows both the gross morphology and the small structures in the lamina cribrosa to be revealed because motion artifacts and motion induced discontinuities are reduced. Changes in the mechanical properties and shape of the lamina 29,30 are thought to lead to retinal ganglion cell death and the associated onset of glaucoma. The ability to investigate the structure of the lamina cribrosa, as well as track changes to the morphology over time, could prove to be important in understanding how the eye changes with age and ultimately lead to improved diagnostics and treatments for glaucoma.…”

Section: Ultrahigh Speed 3d Volumetric Acquisitions and Dense 2d Crosmentioning

confidence: 99%

Ultrahigh speed spectral/Fourier domain ophthalmic OCT imaging

Potsaid

Gorczyńska

Srinivasan

et al. 2009

Ophthalmic Technologies XIX

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Ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) using a CMOS line scan camera with image acquisition rates of 70,000 -312,500 axial scans per second is investigated. Several design configurations are presented to illustrate design trade-offs between acquisition speed, sensitivity, resolution and sensitivity roll-off performance. We demonstrate: extended imaging range and improved sensitivity roll-off at 70,000 axial scans per second with 4096 camera pixels, high speed and ultrahigh resolution imaging at 106,382 axial scans per second, and ultrahigh speed imaging at 250,000-312,500 axial scans per second. Each configuration is characterized through optical testing and the trade-offs demonstrated with in vivo imaging of the fovea and optic disk in the human retina. We show dense homogeneous 3D-OCT volumetric data sets that were acquired by raster scanning at 250,000 axial scans per second, which is an order of magnitude faster than most current generation spectral / Fourier OCT instruments. OCT fundus images constructed from the 3D-OCT data have no noticeable discontinuity of retinal features and show that there are minimal motion artifacts. Using an improved sensitivity roll-off configuration at 70,000 axial scans per second, long cross sectional scans are acquired at high resolution for imaging large areas of the retina, including the fovea and optic disk. Using an ultrahigh speed configuration at 250,000 axial scans per second, the fine porous structures of the lamina cribrosa can be seen from slices extracted from a dense 3D data set. Rapid repeated imaging of a small volume (4D-OCT) enables time resolved visualization of the capillary network surrounding the INL and may show individual red blood cells. This capability could create the possibility for alternative techniques for quantifying capillary blood flow, which cannot be measured with Doppler OCT methods because of the capillary's perpendicular orientation to the optical beam. The results of this study suggest that high speed CMOS cameras can achieve a significant improvement in performance for ophthalmic imaging. This promises to have a powerful impact in clinical applications by improving early diagnosis, reproducibility of quantitative measurements and enabling more sensitive assessment of disease progression or response to therapy.

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Age-related compliance of the lamina cribrosa in human eyes

Cited by 48 publications

References 7 publications

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Age-related changes in the thickness of the human lamina cribrosa

Ultrahigh speed spectral/Fourier domain ophthalmic OCT imaging

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