2013
DOI: 10.1101/lm.030064.112
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Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule

Abstract: Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functional plasticity and is required to modulate cognitive and emotional behaviors. However, whether aging is associated with NCAM alterations that might contribute to age-related cognitive decline is not currently known. In this study, we determined whether condi… Show more

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Cited by 36 publications
(29 citation statements)
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“…A similar interaction might also be required for working memories in vertebrates. Aging mice show reduced expression of NCAM-140 in the medial prefrontal cortex and a conditional knock-out of NCAM in the forebrain promotes AMI in a delayed matching-to-place test in the Morris water maze and in a delayed reinforced alternation test in the T-maze [31]. …”
Section: Resultsmentioning
confidence: 99%
“…A similar interaction might also be required for working memories in vertebrates. Aging mice show reduced expression of NCAM-140 in the medial prefrontal cortex and a conditional knock-out of NCAM in the forebrain promotes AMI in a delayed matching-to-place test in the Morris water maze and in a delayed reinforced alternation test in the T-maze [31]. …”
Section: Resultsmentioning
confidence: 99%
“…The second one is NCAM1 , which is also a target of both RUNX2 (Kuhlwilm et al, 2013) and FOXP2 (Konopka et al, 2009). In mice mutations in the gene affect working/episodic-like memory (Bisaz et al, 2013), whereas overexpression of the Ncam1 extracellular proteolytic cleavage fragment impacts on GABAergic innervation, affecting long- and short-term potentiation in the prefrontal cortex (Brennaman et al, 2011). NCAM1 encodes a cell adhesion protein involved in axonal and dendritic growth and synaptic plasticity (Rønn et al, 2000; Hansen et al, 2008).…”
Section: Asd and The Genetics Of The Domestication Syndromementioning
confidence: 99%
“…In recent decades, the progressive reduction of structural and functional plasticity in hippocampus and the prefrontal cortex were thought to be associated with the gradual decline in cognitive function (24). There was a close associated between synaptic plasticity and sex hormones.…”
Section: Introductionmentioning
confidence: 99%