Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

Abstract

Aged memory‐impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ42) and serum testosterone compared with young animals and non–memory‐impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging‐associated senile dementia of the Alzheimer type.