Age related changes of the extracellular matrix and stem cell maintenance

Kurtz, Armin; Oh, Su-Jun

doi:10.1016/j.ypmed.2012.01.003

Cited by 98 publications

(75 citation statements)

References 99 publications

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“…21 Kurtz et al observed increased expression of pluripotency markers and differentiation potential in old MSCs following seeding on DECM formed by young ADSCs. 48 Our work showed that, after incubation in chondrogenic or adipogenic medium, human adult SDSCs expanded on fetal DECM had greater production of chondrogenic marker genes [SOX9, aggrecan (ACAN), and collagen type II (COL2A1)], glycosaminoglycan (GAG) and collagen type II, or adipogenic markers lipopolysaccharide (LPL) and PPARG, respectively, though this pattern was not observed following treatment with osteogenic medium. 1 These studies very strongly suggest that culture of old MSCs on young DECM rejuvenates the ability of old MSCs to differentiate.…”

Section: Rejuvenation Of Elderly Cells By Young Ecmmentioning

confidence: 71%

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Lynch

Pei²

2014

Organogenesis

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A recent paper demonstrated that decellularized extracellular matrix (DECM) deposited by synovium-derived stem cells (SDSCs), especially from fetal donors, could rejuvenate human adult SDSCs in both proliferation and chondrogenic potential, in which expanded cells and corresponding culture substrate (such as DECM) were found to share a mutual reaction in both elasticity and protein profiles (see ref.

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Section: Rejuvenation Of Elderly Cells By Young Ecmmentioning

confidence: 71%

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Lynch

Pei²

2014

Organogenesis

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“…In addition, physical and physiological parameters of the niche such as shape, elasticity, blood flow and oxygen tension influence stem cell differentiation and self-renewal and regulate the metabolic activity [22,[26][27][28][29][30][31][32]. The interactions between stem cells and their niche are reciprocal; since stem cells are able to remodel the niche and secrete ECM components in response to the signals they receive from it [33][34][35]. …”

Section: Stem Cell Nichesmentioning

confidence: 99%

Pluripotent Stem Cells and Their Dynamic Niche

Reinwald¹,

Bratt²,

Haj³

2016

Pluripotent Stem Cells - From the Bench to the Clinic

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Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ability to selfrenew and commit towards numerous cell types. In vivo, stem cells reside in a dynamic niche, a stem cell-specific microenvironment that possesses chemical, biological and mechanical cues, which drive the stem cell fate and renewal. The connection between stem cells and their niche is a two-way relationship consisting of both cell-cell interaction and cell-extracellular matrix (ECM) interactions. An alternative regenerative medicine approach is the manipulation of the stem cell microenvironment. Hence, novel strategies have been developed including 3D biomaterials and bioreactor technologies providing topographical, chemical and mechanical cues to recreate the stem cell niche. Understanding the mechanisms controlling stem cell fate and the dynamic nature of the stem cell niche will enable researchers to replicate this stem cell-specific microenvironment, and therefore, harness and control the valuable attributes which stem cells possess. This chapter elucidates the importance of pluripotent stem cells and their dynamic niche in regenerative medicine. It further presents novel strategies to replicate chemical, topographical and mechanical stimuli which are essential for the regulation of stem cell fate and hence tissue regeneration.

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“…On the other hand, evidence in vivo showed the relevance of the ECM and the stem cell behavior in that the altered properties or the aged niches' ability of maintaining stem cells' stemness can be reduced [39] and it further affected stem cell proliferation and updated, which created a vicious cycle. Scientists from Harvard University attempted to study the relationship between human aging and microenvironmental changes between stem cells via the stem cell microenvironment (niche) and they found that altering the aged microenvironment with the young microenvironment can improve the ability of the proliferation and renewal of the stem cells.…”

Section: Stem Cells Can Sustain and Repair The Structure And The Funcmentioning

confidence: 99%

Importance of the stem cell microenvironment for ophthalmological cell-based therapy

Park

Wang

2015

WJSC

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Cell therapy is a promising treatment for diseases that are caused by cell degeneration or death. The cells for clinical transplantation are usually obtained by culturing healthy allogeneic or exogenous tissue in vitro . However, for diseases of the eye, obtaining the adequate number of cells for clinical transplantation is difficult due to the small size of tissue donors and the frequent needs of long-term amplification of cells in vitro , which results in low cell viability after transplantation. In addition, the transplanted cells often develop fibrosis or degrade and have very low survival. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPS) are also promising candidates for cell therapy. Unfortunately, the differentiation of ESCs can bring immune rejection, tumorigenicity and undesired differentiated cells, limiting its clinical application. Although iPS cells can avoid the risk of immune rejection caused by ES cell differentiation post-transplantation, the low conversion rate, the risk of tumor formation and the potentially unpredictable biological changes that could occur through genetic manipulation hinder its clinical application. Thus, the desired clinical effect of cell therapy is impaired by these factors. Recent research findings recognize that the reason for low survival of the implanted cells not only depends on the seeded cells, but also on the cell microenvironment, which determines the cell survival, proliferation and even reverse differentiation. When used for cell therapy, the transplanted cells need a specific three-dimensional structure to anchor and specific extra cellular matrix components in addition to relevant cytokine signaling to transfer the required information to support their growth. These structures present in the matrix in which the stem cells reside are known as the stem cell microenvironment. The microenvironment interaction with the stem cells provides the necessary homeostasis for cell maintenance and growth. A large number of studies suggest that to explore how to reconstruct the stem cell microenvironment and strengthen its combination with the transplanted cells are key steps to successful cell therapy. In this review, we will describe the interactions of the stem cell microenvironment with the stem cells, discuss the importance of the stem cell microenvironment for cell-based therapy in ocular diseases, and introduce the progress of stem cell-based 448March 26, 2015|Volume 7|Issue 2|

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Age related changes of the extracellular matrix and stem cell maintenance

Cited by 98 publications

References 99 publications

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Pluripotent Stem Cells and Their Dynamic Niche

Importance of the stem cell microenvironment for ophthalmological cell-based therapy

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