Age-related changes of cortisol and testosterone secretion are not related to changes in psychosocial measures – Findings from the Men's Health 40+ longitudinal study

The Relation Between Steroid Secretion Patterns and the Androgen Receptor Gene Polymorphism on Physical Health and Psychological Well-Being—Longitudinal Findings From the Men’s Health 40+ Study

“…At first glance, it is thus surprising that we were unable to replicate this effect in the current sample. However, the present finding is in line with a previous report from our group in the same sample, in which we showed that psychosocial markers and biological markers change independently of each other (Lacker et al, 2019). Therefore, the lack of a relationship between the interaction of T and C and psychological well-being might be a phenomenon of healthy aging.…”

“…In general, the literature on age-related hormone alterations in men reports a decrease in sex hormones, with the exception of E2, and an increase in glucocorticoid levels is also well documented (Fiacco et al, 2018). Our findings support this, showing a decrease in T, an increase in C, and stable E2 levels (Lacker et al, 2019). The finding that physical health and psychological well-being remained stable in our sample is highly interesting considering that in the general population, a continuous age-related decline in both health dimensions has been reported (Murphy et al, 2017).…”

“…After completion of the screening, participants who dropped out reported that they did not have sufficient time for the study or they were no longer eligible (i.e., no longer reported at least good self-rated health). Detailed information on the dropout rate is described elsewhere (Lacker et al, 2019).…”