Age-related changes of bone ultrasound measurements and metabolic indicators in the young horse

Fradinho, Maria João; Mateus, L.; Bessa, Rui J.B.; Caldeira, Rui; Ferreira‐Dias, Graça

doi:10.1016/j.livsci.2018.03.007

Cited by 3 publications

(4 citation statements)

References 65 publications

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“…As for the SOS measurements we could not find any reports relating plasma leptin concentrations and OC status in the horse. Nevertheless, the increased values observed in the last two age-classes are in agreement with the change pattern reported by our research group [65].…”

Section: Discussionsupporting

confidence: 93%

“…The P i and Mg concentrations were not influenced by OC status and followed the age-change pattern previously described [65]. Very few studies have investigated basal P i and Mg plasma concentrations in relation to OC, but the lack of differences in P i and Mg blood concentrations between positive and negative OC horses was also reported elsewhere [31].…”

Section: Discussionsupporting

confidence: 72%

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Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study

et al. 2019

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Development of a healthy musculoskeletal system is of high concern for horse breeders and users. A longitudinal field study was performed in order to: (i) evaluate growth patterns and long-term changes on bone quality, bone metabolism, growth factors and metabolic variables in the Lusitano horse; and (ii) retrospectively assess whether these changes were related with radiographic findings regarding osteochondrosis-like lesions (OC) at the onset of training. Thirty-four Lusitano foals born and raised at four stud-farms, were periodically weighed (BW), and measured (withers height-WH) from birth to 36 months of age. On the same days, blood samples were collected for determination of osteocalcin, bone alkaline phosphatase, insulin-like growth factor I (IGF-I), leptin, insulin, glucose, parathyroid hormone (PTH), calcium, phosphorus and magnesium plasma concentrations, and quantitative ultrasound measurements were performed on the right third metacarpal bone (McIII). At the end of the study horses underwent radiographic examination of the four fetlocks, hocks and stifles. According to their radiographic status (OC negative vs . OC positive), Richards growth function was adjusted to BW and WH data. Instantaneous BW and WH growth rates (BW IADG and WH IADG) were calculated for each foal, from the resolution of the first derivative of growth models for seven age-classes. The presence of radiographic findings compatible with OC at the onset of training was associated with changes in BW and WH growth rates. Positive horses presented higher BW IADG from six to 18 months of age and lower WH IADG before 45 days of age (P<0.001). Speed of sound measurements (SOS), bone markers, growth factors and other metabolic variables change markedly with age (P<0.01). OC positive horses tended to have lower SOS values at the lateral region of McIII, lower IGF-I, and higher insulin and PTH concentrations (P<0.1). This study provides indirect evidence that monitoring foals’ growth during the first year of life may be of assistance in managing the occurrence of OC. Further studies with a higher number of animals and a controlled feed intake should be pursued.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 72%

Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study

et al. 2019

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“…Outros trabalhos observaram correlação entre as concentrações de IGF-1 e os marcadores de formação óssea em cavalos, como a osteocalcina, um marcador específico da atividade osteoblástica e formação óssea (DAVICCO et al, 1994;van der EERDEN;KARPERIEN;WIT, 2003;FRADINHO et al, 2018). Nós também observamos essa correlação, obtendo o mesmo valor de coeficiente de correlação que Fradinho et al, 2018 (0,37) trabalhando com 27 potros monitorados do nascimento aos 36 meses de idade.…”

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“…. Esse hormônio vem sendo associado à renovação óssea, maturação da cartilagem e crescimento médio diário, estimulando ainda diferenciação e proliferação de mioblastos (LAWRENCE, 2009;FRADINHO et al, 2018). No nosso trabalho, os potros nascidos de éguas que lactavam na gestação inicial, apresentaram valores de IGF-1 muito menores do que os das que não passaram por essa condição no início da gestação.…”

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>b<Avaliação da dinâmica insulina-glicose, citocinas inflamatórias e marcadores metabólicos em éguas gestantes e seus potros>/b<

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Comparison between different sources of minerals in horses with nutritional secondary hyperparathyroidism

Gobesso

Wajnsztejn

Ribeiro³

et al. 2021

Arq. Bras. Med. Vet. Zootec.

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Minerals perform several functions in the body, such as coagulation actions, muscle contraction, enzymatic and hormonal production, among others. This study aims to evaluate the effect of a 150 days chelated and not chelated mineral supplementation with and without potassium oxalate on serological parameters and bone mineral density of horses. Twenty-four crossbred yearlings (12 females and 12 males) with an average age of 21±3 months and body weight of 330.8±37.9kg were divided into four groups containing six equines in each (three females and three males) in a completely randomized design with repeated measurements in a 2x2 factorial arrangement. Treatments were: 1 - chelated minerals compound; 2 - chelated minerals compound and potassium oxalate; 3 - not chelated minerals compound; and 4 - not chelated minerals compound and potassium oxalate. Clinical signs of nutritional secondary hyperparathyroidism (NSH) were observed only in treatment 4. Results showed no treatment effect in bone biopsy for calcium, phosphorus and bone density. There were significant reductions of parathyroid hormone (PTH) means concentrations in treatments 2 and 4 during supplementation. Animals supplemented with chelated minerals compounds avoided mineral imbalances and NSH even when in dietary potassium oxalate challenged.

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Age-related changes of bone ultrasound measurements and metabolic indicators in the young horse

Cited by 3 publications

References 65 publications

Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study

Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study

>b<Avaliação da dinâmica insulina-glicose, citocinas inflamatórias e marcadores metabólicos em éguas gestantes e seus potros>/b<

Comparison between different sources of minerals in horses with nutritional secondary hyperparathyroidism

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