Age-related changes of bone strength phenotypes: observational follow-up study of hand bone mineral density

Malkin, Ida; Bigman, Galya; Matias, R.; Kalichman, Leonid; Seibel, Markus J.; Kobyliansky, Eugene; Livshits, Gregory

doi:10.1007/s00198-006-0233-8

Cited by 8 publications

(14 citation statements)

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“…The association analysis was conducted on age‐adjusted variables. For each trait, the best‐fitting polynomial model of age dependence was found as described elsewhere . Heritability estimates for each trait were obtained using variance component analysis as repeatedly described by us previously and implemented in the statistical package MAN .…”

Section: Methods and Proceduresmentioning

confidence: 99%

Common FSNP variants of fourteen Bardet‐Biedl syndrome genes and adult body mass

Birk

Ermakov

Livshits

2013

Obesity

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Objective: Bardet-Biedl syndrome (BBS) is a rare monogenic multi-systemic disorder manifesting with marked obesity. Fourteen BBS genes have been identified to date and additional loci are expected. Mutations of several BBS genes were shown to affect fat cell differentiation. The purpose was to investigate the association between common polymorphisms in all 14 genes as a group and body weight. Design and Methods: We investigated association between tagging single nucleotide polymorphisms (tSNPs) located between 10 kb upstream and downstream from the transcribed sequences of each of 14 BBS genes, and body weight and fat in 2462 adult women from the UK Twins study. Significant results were further tested in a confirmation sample of 2003 women from the same cohort and additionally in the GIANT consortium population (n ¼ 123,865). Results: 105 SNPs in 14 BBS genes were selected and tested in the first cohort of women for association with the body weight and fat related phenotypes, i.e. weight, body mass index (BMI), total body fat (assessed by DEXA), total fat/height 2 , and total fat/weight. We used principal component (PC) derived using the latter five traits as a primary phenotype for this study. Of the 105 SNPs, 3 variants in BBS9 and BBS11 showed evidence of nominally significant association with elevated body weight and fat. However, none of the associations survived multiple-testing correction. Conclusions: The results suggest that common variation in 14 BBS genes (within or adjacent to the genes) are unlikely to have a substantial effect on body weight and fat in the European population.

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Section: Methods and Proceduresmentioning

confidence: 99%

Common FSNP variants of fourteen Bardet‐Biedl syndrome genes and adult body mass

Birk

Ermakov

Livshits

2013

Obesity

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“…A rural population is more homogeneous than an urban population in terms of ethnicity, occupation, and physical activity. The studied sample was described in detail elsewhere (Kalichman et al, 2006; Malkin et al, 2006). Briefly, data were gathered twice: in 1994 and 2002.…”

Section: Methodsmentioning

confidence: 99%

“…Similar to all the other human body systems, the adult human skeleton undergoes significant changes with age. These changes concern not only widely discussed bone mineral content and density (Ensrud et al, 1995; Miller, 2005; Malkin et al, 2006; Toledo and Jergas, 2006) but also other characteristics of bone associated with bone strength and fragility. This includes the length of long bones, their cross‐sectional area, as well as the thickness of the bones' cortical wall.…”

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confidence: 95%

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Age‐Related Changes in Bone‐Strength‐Associated Geometry Indices in Naive Human Population

Kalichman

Malkin

Bigman

et al. 2008

The Anatomical Record

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The aim of the present study was to evaluate age-and sex-related changes in the geometry parameters (metacarpal cortical index (MCI) and Breaking Bending Resistance Index [BBRI]) of long hand bones in a large Chuvashian cohort using cross-sectional and longitudinal study designs. The data were gathered in 1994 (557 individuals) and 2002 (513 individuals). The latter sample included 260 individuals who were studied only during the second expedition, and 253 individuals who were previously investigated in 1994. Statistical analyses included a maximum likelihood-based model-fitting technique and a t-test comparison. Our study describes age-related MCI and BBRI changes in both sexes from the age of 18 years to 84 years. At any age, the BBRI values were higher in males than in females, but MCI was greater in females than in males before age 50 and lower after that age. The study provides initial evidence of a secular trend in MCI and BBRI. In male hand bones, the cortex became relatively thicker and it better resisted bending and breaking in comparison to individuals born at the beginning of the 20th century. In females, the trend toward higher MCI values can be observed only in those born between 1936 and 1966 and the trend toward higher BBRI values stopped in 1950. Anat Rec,

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“…Malkin ve ark. [33], yapmış olduğu bir çalışmada her iki cinsiyette de digital radyografik dansitometre ile ölçülen el KMY'sinin yaşla ilişkili deği-şiklikleri değerlendirilmiştir. Erkeklerde 3. dekadın ilk yarısından sonra tüm yaşlarda el KMY azalmış fakat her yaşta kadınlarınkinden yüksek kalmıştır.…”

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Determination of the standard values of the hand bone mineral density values in males according to ages

Temiztürk¹

2013

Diclemedj

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Objective: In this study we purposed to determine standardvalues of hand Bone Mineral Density (BMD) accordingto ages by Dual Energy X-Ray Absorptiometry (DXA)in males who applied to our hospital, evaluate associationof hand BMD with lumbar and femur BMD and searchusefulness of hand BMD measurement by DXA.Methods: Totally, 239 male included, whose ages differbetween 27 to 87 years, had no disease associatedwith bone density were included. The cases, betweenthe ages 20 to 70 separated to age groups, comprisedof 5 years. Cases, whose age is 70 and older, included inthe same group. Average of dominant and nondominanthand BMD values of the chosen cases were computedaccording to age groups comprised of 5 years and theassociation with values of L2-L4 and femur neck BMD issearched separately.Results: There is significant association between dominanthand BMD scores with L2-L4 and femur neck BMDscores. Also there is significant association between nondominanthand BMD scores with L2-L4 and femur neckBMD scores. Also there is asignificant association betweenscores of hand BMD with hand grip strenght.Conclusion: In this study there is significant associationbetween BMD scores of dominant and nondominanthand with BMD scores of L2-L4 and femur neck in all agegroups. Rheumatological diseases, reflex sympatheticdystrophy, tendon and nerve lacerations of hand and forearm,fractures of upper extremity and hemiplegy, that cancauses local osteoporosis in the hand, measurement ofhand BMD can be done by DXA.Key words: Bone mineral density, dual energy X ray absorptiometry,osteoporosi

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Age-related changes of bone strength phenotypes: observational follow-up study of hand bone mineral density

Cited by 8 publications

References 44 publications

Common FSNP variants of fourteen Bardet‐Biedl syndrome genes and adult body mass

Common FSNP variants of fourteen Bardet‐Biedl syndrome genes and adult body mass

Age‐Related Changes in Bone‐Strength‐Associated Geometry Indices in Naive Human Population

Determination of the standard values of the hand bone mineral density values in males according to ages

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