Age-related changes of blood vessels in the human dermis

Гунин, А. Г.; Petrov, Vadim V.; Vasilieva, O. V.; Golubtsova, N. N.

doi:10.1134/s2079057015020058

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…In the current study, there was a marked reduction in blood vessels in aged rats' CT in both oral mucosa and skin sides of the same Gp, which was confirmed statistically through significant reduction in VEGF-positive cells. This came in agreement with Gunin et al, 2015 [55] as they showed that numbers of blood vessels were gradually reduced by age. This could be due to toxic cytokines produced in chronic inflammation which probably induce death of some existing endothelial cells and impair the regeneration ability of the others [56,57] .…”

Section: Discussionsupporting

confidence: 91%

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

Awwad

Hamid

2020

Egyptian Journal of Histology

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Background: Structural changes occur with aging, associated with fibrosis and inflammation in body tissues. Aging of oral mucosa causes alterations in oral epithelium and sub-epithelial tissues, due to reduction in certain growth factors, endogenous anti-oxidant enzymes, or both. Aim: to assess anti-aging potential of melatonin & vitamin C on albino rats' lips. Materials and Methods: 28 male albino rats were used, divided into: Group I: 7 rats aged 6 months (18 years in humans), Group II: 21 rats aged 24 months (72 years in humans), were equally subdivided into 3 subgroups 7 rats each as follows: Subgroup IIA: positive control for other subgroups; Subgroup IIB: received melatonin via gastric gavage (10mg/kg/day) for six consecutive weeks; Subgroup IIC: received vitamin C via gastric gavage (2mg/ml/day) for six consecutive weeks. At the end of the experiment, rats were sacrificed by a high dose of anesthesia. The lips were excised. Specimens were processed for histological examination, stained by H&E, Masson's Trichrome& Anti-VEGF, examined by light microscope. Results: Subgroup IIA showed statistically significant increase in number of vacuolated epithelial cells, statistically significant reduction in VEGF positive cells, apparent decrease in epithelial thickness, statistically significant reduction in immature collagen fibers' percentage within connective tissue (CT). Subgroups IIB & IIC, showed significant reduction in number of vacuolated epithelial cells and significant increase in VEGF positive cells and area percentage of immature collagen fibers in CT. However, subgroup IIB's epithelial structure showed better image and subgroup IIC's CT structure presented better image. Conclusion: Aging showed structural changes in skin & mucous membrane sides of rat lips, observed within both epithelium and CT. Melatonin & vit. C exhibited efficiency in counteracting these effects. Melatonin presented superior effect on keratinocytes, vit. C showed superiority in repairing senile CT components.

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Section: Discussionsupporting

confidence: 91%

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

Awwad

Hamid

2020

Egyptian Journal of Histology

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“…Currently, age-related changes in the microvasculature of surface tissues are studied using both ex vivo and in vivo methods. The method of immunohistochemical analysis with markers of vascular endothelium showed a gradual decrease in the vascularization of human skin with age [16][17][18]. Decreased capillary loop density and increased vessel length were demonstrated using capillaroscopy and Laser Doppler flowmetry [19,20].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Characterization of Age-Related Changes in Peripheral Vessels of a Human Palm Using Raster-Scan Optoacoustic Angiography

et al. 2022

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The analysis of age-related changes in skin vessels based on optoacoustic angiographic images during the in vivo skin monitoring of healthy volunteers at different ages is reported. As a result of a quantitative analysis of the three-dimensional OA images, the age-associated differences in the following image parameters were revealed: image intensity, ratio of blood content at different characteristics depths, total vessel length, and number of branches. The reported approach can be effectively employed for automatic assessment and monitoring of age-related vascular changes in the skin and underlying tissues.

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“…Inflammatory cells escaped from these vessels result in cutaneous inflammation and further degradation and reconstruction of dermal ECM. Large amount of high toxic compounds released from new blood vessels to skin tissue may also induce skin damage and aging [34,35]. Angiogenesis has been proved to be functionally associated with photoaging-related wrinkle formation [36].…”

Section: Mast Cell and Angiogenesismentioning

confidence: 99%

The Role of the Mast Cell in Skin Aging

Yang-lin¹,

Wei²,

Li³

et al. 2016

J Dermatol Res Ther

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Skin is the external organ of human body that provides protection against environmental stress. Direct and indirect damage causes skin aging. Scientists have been struggling to explore the mechanisms of skin aging and to think of ways to delay this course. The role of mast cell in regulating skin aging has attracted much attention recently. The granules of mast cell contain a great diversity of highly toxic compounds and active mediators. Degranulation of mast cell in papillary dermis may lead to extra cellular matrix reconstruction, inflammation and angiogenesis which result in accelerated skin aging. Essential factors implicated in aging and tissue damage in skin are possibly related to mast cells. Mast cell is becoming an important target for anti-aging therapy. Many natural products capable of inhibiting mast cell activation are considered functional ingredients for anti-skin aging.

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Age-related changes of blood vessels in the human dermis

Cited by 15 publications

References 21 publications

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

Quantitative Characterization of Age-Related Changes in Peripheral Vessels of a Human Palm Using Raster-Scan Optoacoustic Angiography

The Role of the Mast Cell in Skin Aging

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